Ownership Submission
FORM 3
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  Motheral Brenda
 2. Date of Event Requiring Statement (Month/Day/Year)
01/01/2006		 3. Issuer Name and Ticker or Trading Symbol
EXPRESS SCRIPTS INC [ESRX]
(Last)
(First)
(Middle)
13900 RIVERPORT DRIVE		 4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
SVP Research & Product Mngmt
 5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

MARYLAND HEIGHTS, MO 63043		 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		 2. Amount of Securities Beneficially Owned
(Instr. 4)		 3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		 4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 3,016
D
 

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)		 2. Date Exercisable and Expiration Date
(Month/Day/Year)		 3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		 6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Non-Qualified Stock Option (Right-to-Buy)   (1) 12/18/2009 Common Stock 4,000 $ 23.975 D  
Non-Qualified Stock Option (Right-to-Buy)   (2) 03/05/2011 Common Stock 7,016 $ 37.58 D  
Non-Qualified Stock Option (Right-to-Buy)   (3) 11/12/2011 Common Stock 3,600 $ 19.62 D  
Non-Qualified Stock Option (Right-to-Buy)   (4) 03/01/2012 Common Stock 10,314 $ 38.64 D  
Non-Qualified Stock Option (Right-to-Buy)   (5) 05/24/2012 Common Stock 9,000 $ 47.14 D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
Motheral Brenda
13900 RIVERPORT DRIVE
MARYLAND HEIGHTS, MO 63043		       SVP Research & Product Mngmt  

Signatures

Brenda Motheral 01/02/2006
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Option vests in three equal installments on December 18, 2003, December 18, 2004, and December 18, 2005.
(2) Option vests in three equal installments on March 5, 2005, March 5, 2006, and March 5, 2007.
(3) Option vests in three equal installments on November 12, 2002, November 12, 2003, and November 12, 2004.
(4) Option vests in three equal installments on March 1, 2006, March 1, 2007, and March 1, 2008.
(5) Option vests 1/3 on May 24, 2007, and 2/3 on May 24, 2008.

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