Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number: 3235-0287
Expires: January 31, 2005
Estimated average burden hours per response... 0.5

(Print or Type Responses)
1. Name and Address of Reporting Person *
COOPER GLENN L MD
  2. Issuer Name and Ticker or Trading Symbol
INDEVUS PHARMACEUTICALS INC [IDEV]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
President and CEO
(Last)
(First)
(Middle)
INDEVUS PHARMACEUTICALS, INC., 33 HAYDEN AVENUE
3. Date of Earliest Transaction (Month/Day/Year)
12/04/2008
(Street)

LEXINGTON, MA 02421
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number. SEC 1474 (9-02)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (Right to Buy) $ 5 12/04/2008   D(1)     60,000   (2) 06/10/2009 Common Stock, $.001 par value per share 60,000 $ 0 (1) 0 D  
Stock Option (Right to Buy) $ 5 12/04/2008   A(1)   60,000     (3) 12/10/2010 Common Stock, $.001 par value per share 60,000 $ 0 (1) 60,000 D  
Stock Option (Right to Buy) $ 6.1875 12/04/2008   D(1)     800,000   (2) 06/10/2009 Common Stock, $.001 par value per share 800,000 $ 0 (1) 0 D  
Stock Option (Right to Buy) $ 6.1875 12/04/2008   A(1)   800,000     (3) 12/10/2010 Common Stock, $.001 par value per share 800,000 $ 0 (1) 800,000 D  
Stock Option (Right to Buy) $ 4.1563 12/04/2008   D(1)     360,000   (2) 06/10/2009 Common Stock, $.001 par value per share 360,000 $ 0 (1) 0 D  
Stock Option (Right to Buy) $ 4.1563 12/04/2008   A(1)   360,000     (3) 12/10/2010 Common Stock, $.001 par value per share 360,000 $ 0 (1) 360,000 D  
Stock Option (Right to Buy) $ 6.1875 12/04/2008   D(4)     70,000   (2) 06/10/2009 Common Stock, $.001 par value per share 70,000 $ 0 (4) 0 I (4) Spouse
Stock Option (Right to Buy) $ 6.1875 12/04/2008   A(4)   70,000     (3) 06/10/2010 Common Stock, $.001 par value per share 70,000 $ 0 (4) 70,000 I (4) Spouse

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
COOPER GLENN L MD
INDEVUS PHARMACEUTICALS, INC.
33 HAYDEN AVENUE
LEXINGTON, MA 02421
  X     President and CEO  

Signatures

 GLENN L COOPER MD   12/08/2008
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) All of the reported transactions involved the amendment of outstanding stock options to extend the respective expiration dates from 6/10/2009 to 12/10/2010; such extensions are considered by the Securities and Exchange Commission to be cancellations of the current stock options.
(2) Prior to the extension of the current stock option, such stock option was fully exercisable.
(3) This stock option is fully exercisable as of the date of this report.
(4) Dr. Cooper disclaims all beneficial ownership in these options held by his spouse. All of the reported transactions involved the amendment of outstanding stock options held by Dr. Cooper's spouse to extend the respective expiration dates from 6/10/2009 to 6/10/2010; such extensions are considered by the Securities and Exchange Commission to be cancellations of the current stock options.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.