SCHEDULE 14A
                                 (Rule 14a-101)

                     INFORMATION REQUIRED IN PROXY STATEMENT

                            SCHEDULE 14A INFORMATION

           Proxy Statement Pursuant to Section 14(a) of the Securities
                              Exchange Act of 1934

Filed by the Registrant |X|
Filed by a Party other than the Registrant |_|

Check the appropriate box:
|_| Preliminary Proxy Statement      |_| Confidential, For Use of the Commission
                                         Only (as permitted by Rule 14a-6(e)(2))

|X| Definitive Proxy Statement
|_| Definitive Additional Materials
|_| Soliciting Material Under Rule 14a-12


                               Cytogen Corporation
--------------------------------------------------------------------------------
                (Name of Registrant as Specified in Its Charter)



--------------------------------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement, if Other Than the Registrant)

Payment of Filing Fee (Check the appropriate box):
     |X| No fee required.
     |_| Fee computed on table below per Exchange Act Rules 14a-6(i)(1)and 0-11.


     (1) Title of each class of securities to which transaction applies:

--------------------------------------------------------------------------------

     (2) Aggregate number of securities to which transaction applies:

--------------------------------------------------------------------------------

     (3) Per unit price or other underlying value of transaction computed
pursuant to Exchange Act Rule 0-11 (set forth the amount on which the filing fee
is calculated and state how it was determined):

--------------------------------------------------------------------------------

     (4) Proposed maximum aggregate value of transaction:

--------------------------------------------------------------------------------

     (5) Total fee paid:

--------------------------------------------------------------------------------

     |_| Fee paid previously with preliminary materials.

--------------------------------------------------------------------------------

     |_| Check box if any part of the fee is offset as provided by Exchange Act
     Rule 0-11(a)(2) and identify the filing for which the offsetting fee was
     paid previously. Identify the previous filing by registration statement
     number, or the form or schedule and the date of its filing.

--------------------------------------------------------------------------------

     (1) Amount previously paid:

--------------------------------------------------------------------------------

     (2) Form, Schedule or Registration Statement No.:

--------------------------------------------------------------------------------

     (3) Filing Party:

--------------------------------------------------------------------------------

     (4) Date Filed:

--------------------------------------------------------------------------------

                               CYTOGEN CORPORATION
                              600 College Road East
                           Princeton, New Jersey 08540

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                            To Be Held June 19, 2001

         The Annual Meeting of Stockholders (the "Meeting") of CYTOGEN
CORPORATION, a Delaware corporation (the "Company"), will be held at the Holiday
Inn, Route One at Ridge Road, Princeton, New Jersey, on Tuesday June 19, 2001,
at 11:00 A.M., local time, for the following purposes:

(1)    To elect seven directors to serve until the next Annual Meeting of
       Stockholders and until their respective successors shall have been duly
       elected and qualified;

(2)    To amend the Company's 1999 Non-Employee Director Stock Option Plan (the
       "Director Plan") to: (A) increase the number of shares of Common Stock
       underlying automatic initial option grants under the Director Plan to new
       non-employee Directors from 10,000 to 20,000 shares; and (B) provide, in
       certain circumstances, at the discretion of and after formal action by
       the Board of Directors, for the issuance of Common Stock under the
       Director Plan to Directors, in lieu of the cash component of Director
       compensation;

(3)    To amend the Company's Employee Stock Purchase Plan (the "ESPP") to: (A)
       decrease, from one year to six months, the term of service required to be
       eligible to participate therein; and (B) delete the requirement for
       stockholder approval of any modification of the ESPP with respect to
       eligibility for participation in the ESPP; and

(4)    To transact such other business as may properly come before the Meeting
       or any adjournment or adjournments thereof.

         Holders of Common Stock of record at the close of business on April 23,
2001 are entitled to notice of and to vote at the Meeting, or any adjournment or
adjournments thereof. A complete list of such stockholders will be open to the
examination of any stockholder at the Company's principal executive offices at
600 College Road East, Princeton, New Jersey 08540 for a period of 10 days prior
to the Meeting. The Meeting may be adjourned from time to time without notice
other than by announcement at the Meeting.

         IT IS IMPORTANT THAT YOUR SHARES BE REPRESENTED REGARDLESS OF THE
NUMBER OF SHARES YOU MAY HOLD. WHETHER OR NOT YOU PLAN TO ATTEND THE MEETING IN
PERSON, PLEASE COMPLETE, DATE AND SIGN THE ENCLOSED PROXY CARD AND MAIL IT
PROMPTLY IN THE ENCLOSED RETURN ENVELOPE. THE PROMPT RETURN OF PROXIES WILL
ENSURE A QUORUM AND SAVE THE COMPANY THE EXPENSE OF FURTHER SOLICITATION. EACH
PROXY GRANTED MAY BE REVOKED BY THE STOCKHOLDER APPOINTING SUCH PROXY AT ANY
TIME BEFORE IT IS VOTED. IF YOU RECEIVE MORE THAN ONE PROXY CARD BECAUSE YOUR
SHARES ARE REGISTERED IN DIFFERENT NAMES OR ADDRESSES, EACH SUCH PROXY CARD
SHOULD BE SIGNED AND RETURNED TO ASSURE THAT ALL OF YOUR SHARES WILL BE VOTED.

                                             By Order of the Board of Directors

Princeton, New Jersey                             Catherine M. Verna, Secretary
May 9, 2001


        The Company's 2000 Annual Report accompanies the Proxy Statement.






                               CYTOGEN CORPORATION
                              600 College Road East
                           Princeton, New Jersey 08540

--------------------------------------------------------------------------------

                                 PROXY STATEMENT

--------------------------------------------------------------------------------

         This Proxy Statement is furnished in connection  with the  solicitation
by the Board of Directors of Cytogen  Corporation  (the "Company") of proxies to
be voted at the Annual  Meeting  of  Stockholders  of the  Company to be held on
Tuesday,  June 19, 2001 (the  "Meeting") at the Holiday Inn,  Route One at Ridge
Road, Princeton, New Jersey at 11:00 a.m., local time, and at any adjournment or
adjournments  thereof.  Holders of record of Common  Stock,  $.01 par value (the
"Common Stock"), as of the close of business on April 23, 2001, will be entitled
to notice of and to vote at the  Meeting  and any  adjournment  or  adjournments
thereof.  As of that date,  there were 77,489,276  shares of Common Stock issued
and  outstanding and entitled to vote. Each share of Common Stock is entitled to
one vote on any matter presented at the Meeting.  The aggregate number of Common
Stock votes  entitled to be cast at the  Meeting is  77,489,276.  The holders of
Common Stock will vote as a single class for all proposals.

         If proxies in the accompanying form are properly executed and returned,
the  shares of Common  Stock  represented  thereby  will be voted in the  manner
specified  therein.  If not  otherwise  specified,  the  shares of Common  Stock
represented  by the proxies  will be voted:  (i) FOR,  the election of the seven
nominees  named below as  Directors;  (ii) FOR a proposal to amend the Company's
1999  Non-Employee  Director  Stock  Option Plan (the  "Director  Plan") to: (A)
increase  the  number of shares of Common  Stock  underlying  automatic  initial
option grants under the Director Plan to new non-employee  Directors from 10,000
to 20,000 shares; and (B) provide, in certain  circumstances,  at the discretion
of and after formal action by the Board of Directors, for the issuance of Common
Stock under the Director  Plan to  Directors,  in lieu of the cash  component of
Director  compensation;  (iii) FOR a proposal  to amend the  Company's  Employee
Stock Purchase Plan (the "ESPP") to: (A) decrease,  from one year to six months,
the term of service  required  to be eligible to  participate  therein;  and (B)
delete the requirement for stockholder  approval of any modification of the ESPP
with  respect to  eligibility  for  participation  in the ESPP;  and (iv) in the
discretion  of the persons  named in the  enclosed  form of proxy,  on any other
proposals  which may  properly  come  before the Meeting or any  adjournment  or
adjournments thereof. Any stockholder who has submitted a proxy may revoke it at
any time before it is voted, by written notice  addressed to and received by the
Secretary of the Company,  by submitting a duly  executed  proxy bearing a later
date or by electing to vote in person at the Meeting.  The mere  presence at the
Meeting  of the  person  appointing  a  proxy  does  not,  however,  revoke  the
appointment.

         The  presence,  in person or by proxy,  of  holders of shares of Common
Stock in the aggregate having a majority of the votes entitled to be cast by the
holders of Common Stock at the Meeting,  shall  constitute a quorum with respect
to all matters presented.  The affirmative vote by the holders of a plurality of
the  shares of Common  Stock  represented  at the  Meeting is  required  for the
election  of  directors,  provided a quorum of such  stockholders  is present in
person or by proxy.  All  actions  proposed  herein  other than the  election of
directors may be taken upon the affirmative  vote of  stockholders  possessing a
majority of the requisite  voting power  represented at the Meeting,  provided a
quorum is present in person or by proxy.

         Abstentions  are  included  in the shares  present at the  Meeting  for
purposes of determining  whether a quorum is present,  and are counted as a vote
against for  purposes of  determining  whether a proposal  is  approved.  Broker
non-votes  (when shares are  represented at the Meeting by a proxy  specifically
conferring only limited authority to vote on certain matters and no authority to
vote on other matters) are included in the determination of the number of shares
represented  at the Meeting  for  purposes  of  determining  whether a quorum is
present but are not counted for purposes of  determining  whether a proposal has
been approved and thus have no effect on the outcome.

         This Proxy  Statement,  together  with the related proxy card, is being
mailed to the  stockholders  of the Company on or about May 9, 2001.  The Annual
Report to  Stockholders  of the Company for the year ended  December  31,  2000,
including financial  statements (the "Annual Report"),  is being mailed together
with this Proxy Statement to all stockholders of record as of April 23, 2001. In



addition, the Company has provided brokers,  dealers, banks, voting trustees and
their nominees,  at the Company's expense,  with additional copies of the Annual
Report so that such record  holders  could supply such  materials to  beneficial
owners as of April 23, 2001.

                              ELECTION OF DIRECTORS

         At the Meeting,  seven  directors are to be elected (which number shall
constitute  the entire  Board of  Directors of the Company) to hold office until
the next Annual Meeting of Stockholders  and until their  successors  shall have
been elected and qualified. The holders of Common Stock, voting as a class, will
elect each such director.

         It is the  intention of the persons named in the enclosed form of proxy
to vote the stock represented thereby,  unless otherwise specified in the proxy,
for the election as directors of the persons whose names and biographies  appear
below.  All such persons are at present  directors of the Company.  In the event
any of the nominees should become  unavailable or unable to serve as a director,
it is intended  that votes will be cast for a substitute  nominee  designated by
the Board of Directors. The Board of Directors has no reason to believe that the
nominees  named will be unable to serve if  elected.  Each of the  nominees  has
consented to being named in this Proxy Statement and to serve if elected.

         The current members of the Board of Directors who are also nominees for
election to the Board of Directors are as follows:




                                                        Served as a                    Positions with
                 Name                      Age         Director Since                    the Company
-------------------------------------      ---         --------------        ----------------------------------
                                                                    
James A. Grigsby.....................       58              1996             Chairman of the Board

H. Joseph Reiser.....................       54              1998             President, Chief Executive Officer
                                                                             and Director

John E. Bagalay, Jr..................       67              1995             Director

Stephen K. Carter....................       63              1998             Director

Robert F. Hendrickson................       68              1995             Director

Kevin G. Lokay.......................       44              2001             Director

S. Leslie Misrock....................       73              1999             Director



         The principal  occupations  and business  experience,  for at least the
past five years, of each nominee are as follows:

         James A. Grigsby has been a director of the Company  since May 1996 and
Chairman  of the Board  since  June  1998.  Mr.  Grigsby  serves as a  strategic
consultant to companies in various industries. Since April 1999, Mr. Grigsby has
been  affiliated with the consulting  firm of Nachman,  Hays & Associates,  from
which he accepts occasional  consulting  engagements.  Prior to that time, since
1994, Mr. Grigsby was President of Cancer Care Management LLC, a consulting firm
providing  consulting  services regarding cancer disease management issues. From
1989 to 1994,  Mr.  Grigsby was President of CIGNA  Corporation's  International
Life  and  Employee  Benefits  Division,  which  operated  in over 20  countries
worldwide, and during that period he also served as the head of CIGNA's national
health care sales  force.  Prior to that time,  since 1978,  he held a number of
executive  positions with CIGNA Corporation.  Mr. Grigsby received a Bachelor of
Arts degree in Mathematics from Baylor University and is a Fellow of the Society
of Actuaries.

         H. Joseph  Reiser joined the  Company  in August  1998 as President and
Chief  Executive  Officer and as a  member of  the  Board of  Directors.   Most
recently,   Dr.  Reiser  was  Corporate  Vice  President  and  General  Manager,
Pharmaceuticals,  for Berlex  Laboratories Inc., the U.S. subsidiary of Schering
AG. During his 17 year tenure at Berlex, Dr. Reiser held positions of increasing
responsibility,  serving as the first  President  of Schering  Berlin's  Venture

                                       2


Corporation,  Vice  President,  Technology  and  Industry  Relations,  and  Vice
President,  Drug  Development and  Technology.  Dr. Reiser received his Ph.D. in
Physiology from Indiana University School of Medicine,  where he also earned his
Masters and Bachelor of Science degrees.

         John E.  Bagalay,  Jr. has been a director of the Company since October
1995.  Dr.  Bagalay  was a director  of  Cellcor,  Inc.  prior to the  Company's
acquisition  of  Cellcor  in  October  1995.  He was  interim  President,  Chief
Executive  Officer and Chief Financial  Officer of the Company from January 1998
to August 1998. He has been Senior Advisor to the Chancellor,  Boston University
since January 1998. He has been a director,  Chief  Operating  Officer and Chief
Financial Officer of Eurus International,  Ltd. since January 1999. He served as
the  Managing  Director  of  Community  Technology  Fund,  the  venture  capital
affiliate of Boston  University,  from  September  1989 until January 1998.  Dr.
Bagalay has also served as General Counsel for Texas Commerce Bancshares and for
the Lower Colorado River Authority,  a regulated  electric utility.  Dr. Bagalay
currently also serves on the boards of directors of Wave Systems Corporation and
UAE,  Inc.  Dr.  Bagalay  holds a Bachelor of Arts in Politics,  Philosophy  and
Economics and a Ph.D. in Political Philosophy from Yale University,  and a Juris
Doctor from the University of Texas.

         Stephen K. Carter  has been a director of the Company  since  September
1998.  Since  1997,  Dr.  Carter  has been a  consultant  to the  pharmaceutical
industry.  Dr. Carter was Senior Vice  President of Research and  Development at
Boehringer Ingelheim  Pharmaceuticals,  Inc. from 1995 to 1997. Prior to joining
Boehringer,  Dr. Carter was Senior Vice President of Worldwide Clinical Research
and Development at Bristol-Myers  Squibb Company.  From 1976 to 1982, Dr. Carter
served as Director of the Northern  California Cancer Institute.  Dr. Carter was
also  appointed  to President  Clinton's  panel for AIDS drug  development.  Dr.
Carter is a director of Allos Therapeutics and Alfacell Corporation.  Dr. Carter
received  an A.B. in History  from  Columbia  College and an M.D.  from New York
Medical College.  He completed a medical  internship and residency at Lenox Hill
Hospital.

         Robert F.  Hendrickson has been a director of  the Company  since March
1995.  Since 1990, Mr.  Hendrickson has been a consultant to the  pharmaceutical
and biotechnology  industries on strategic  management and manufacturing  issues
with a number of leading biotechnology companies among his clients. Prior to his
retirement in 1990, Mr. Hendrickson was Senior Vice President, Manufacturing and
Technology  for Merck & Co.,  Inc.  He is a  director  of  Envirogen,  Inc.  and
Unigene,  Inc., and a trustee of the Carrier  Foundation,  Inc. Mr.  Hendrickson
received  an A.B.  degree  from  Harvard  College  and an  Masters  of  Business
Administration from the Harvard Graduate School of Business Administration.

         Kevin G. Lokay has been a director of the Company  since  January 2001.
Mr. Lokay is currently Vice President, Oncology Business Unit at GlaxoSmithKline
Pharmaceuticals.  Prior to joining  GlaxoSmithKline  in 1997, Mr. Lokay spent 16
years with Merck & Co.,  where his most recent  assignment  was Vice  President,
Worldwide Sales,  Marketing and Development in the Merck Vaccine  Division.  Mr.
Lokay joined Merck in 1981 as a sales  representative,  and  progressed  through
numerous  positions of increasing  responsibilities  in sales,  market research,
advertising,   product  management,  and  business  development,  while  gaining
experience in a wide variety of therapeutic areas, including  antihypertensives,
antiarrythmics, antibiotics, analgesic/anti-inflammatories,  psychotherapeutics,
vaccines, and gastro-intestinal  products. Mr. Lokay holds a Masters of Business
Administration  with a  concentration  in  Marketing  from  Krannert  School  of
Management  at Purdue  University,  and a  Bachelor  of Arts in  Economics  from
Lafayette College.

         S. Leslie Misrock has been a director of the Company since August 1999.
Mr.  Misrock has been a Partner of the law firm of Pennie & Edmonds,  a New York
based intellectual property firm since 1964 and a Senior Partner since 1971. Mr.
Misrock  holds an SB degree in  Chemistry  from the  Massachusetts  Institute of
Technology,  an A.M.  degree in Chemistry  from Columbia  University  and an LLB
degree  from  Fordham  University.  Mr.  Misrock  is a  member  of the  Visiting
Committees of the  Departments of Biology and Chemistry at MIT, The  Association
for the Cure of Prostate Cancer (CaP CURE), the Board of Visitors at Fordham Law
School, the Health Sciences Board of Columbia University's College of Physicians
and Surgeons, and the National Prostate Cancer Coalition.


                                       3


         All  directors  will hold  office  until  the next  annual  meeting  of
stockholders  and until  their  successors  shall  have been  duly  elected  and
qualified.  None of the Company's directors are related to any other director or
to any executive officer of the Company.

         The Board of Directors  recommends that  stockholders  vote FOR each of
the nominees for the Board of Directors.

Committees and Meetings of the Board

         The Board of  Directors  currently  consists of James A.  Grigsby,  who
serves as Chairman of the Board, H. Joseph Reiser,  John E. Bagalay,  Stephan K.
Carter, Robert F. Hendrickson,  Kevin G. Lokay and S. Leslie Misrock. There were
ten (10) meetings of the Board of Directors during 2000. Each incumbent director
attended at least 75% of the aggregate of all meetings of the Board of Directors
held during the period in which he served as a director  and the total number of
meetings  held by the  committee  on which  he  served  during  the  period,  if
applicable.

         There are currently  three  committees of the Board of Directors:  the
Compensation  Committee,  the  Nominating  Committee and  the Audit  and Finance
Committee.

The Compensation Committee of the Board of Directors (the "Compensation
Committee")

         The Compensation Committee currently consists of Robert F. Hendrickson,
who serves as Chairman,  Kevin G. Lokay and S. Leslie Misrock.  The Compensation
Committee  was  established  in 1986 and held three (3)  meetings  in 2000.  The
primary  responsibilities  of the Compensation  Committee include overseeing the
administration  of the Company's stock option plans,  recommending  compensation
for  executive  officers and other key  employees of the Company to the Board of
Directors, and generally reviewing the Company's compensation policy.

The Nominating Committee of the Board of Directors (the "Nominating Committee")

         The Nominating  Committee  currently consists of James A. Grigsby,  who
serves  as  Chairman,  and  H.  Joseph  Reiser.  The  Nominating  Committee  was
established   in  1994  and  held  six  (6)   meetings  in  2000.   The  primary
responsibility  of the  Nominating  Committee is  investigating,  recruiting and
interviewing  potential  candidates for election to the Board of Directors.  The
Nominating Committee will consider nominees for the Board of Directors suggested
by stockholders whose names are submitted in writing to the Nominating Committee
in care of the office of the Corporate Secretary of the Company.

The  Audit and  Finance Committee  of  the  Board  of  Directors  (the "Audit
Committee")

         The Audit  Committee  currently  consists of John E. Bagalay,  Jr., who
serves as  Chairman,  Robert F.  Hendrickson  and Stephen K.  Carter.  The Audit
Committee was established in 1986 and held six (6) meetings in 2000. The primary
responsibilities  of the Audit  Committee,  as more fully set forth in the Audit
Committee  Charter  adopted by the Company's  Board of Directors on May 16, 2000
and attached hereto as Appendix A, include:  (i) evaluating and  recommending to
the Board of Directors the  engagement of the  Company's  independent  auditors;
(ii) reviewing the results and scope of the audit and other services provided by
the Company's independent auditors; and (iii) monitoring and consulting with the
auditors and management regarding risk management, the adequacy of financial and
accounting  procedures  and  internal  controls on a periodic  basis.  The Audit
Committee  also  reviews and  monitors  the  financial  planning  and  financial
structure of the Company to accommodate the operating requirements and strategic
objectives.

         Recently,  the Nasdaq Stock Market has adopted requirements relating to
the  independence of members of the audit committees of companies traded on that
market.  The audit committee  members meet the requirements of that rule, except
that members may not have been  employees of the Company  within the three prior
years.  Dr.  Bagalay  served at the request of the Board of Directors as interim
Chief  Executive  Officer from January  1998  through  August 1998,  pending the
recruitment  of a permanent  Chief  Executive  Officer,  and was deemed to be an
employee  during  this  period.  The new  rules  permit  one  member of an audit
committee to remain on the committee even if the  independence  criteria are not
met in certain  circumstances.  In  accordance  with these  rules,  the Board of


                                       4



Directors  determined that, given his financial expertise and judgment,  and the
brief period of time which he served as an employee upon the Board of Director's
request,  Dr. Bagalay's  continued service on the Audit Committee is in the best
interest of the Company and its stockholders.

         Except as noted above,  each Audit  Committee  member is an independent
member of the Board of Directors as defined in Rule  4200(a)(14) of the National
Association of Securities Dealers' listing standards. As an independent director
of the Board of Directors of the Company,  each Audit Committee Member is not an
officer  or  employee  of the  Company or its  subsidiaries  and does not have a
relationship  which, in the opinion of the Company's  Board of Directors,  would
interfere  with the  exercise  of  independent  judgement  in  carrying  out the
responsibilities of a director.

Report of the Audit Committee

March 15, 2001


To the Board of Directors of Cytogen Corporation:

         We have reviewed and discussed with  management  the Company's  audited
financial statements as of and for the year ended December 31, 2000.

         We have discussed with the independent  public  accountants the matters
required  to  be  discussed  by   Statement  on  Auditing   Standards   No.  61,
Communication with Audit Committees, as amended, by the Auditing Standards Board
of the American Institute of Certified Public Accountants.

         We have  received and reviewed the written  disclosures  and the letter
from the independent public accountants required by Independence Standard No. 1,
Independence Discussions with Audit Committees,  as amended, by the Independence
Standards   Board,   and  have   discussed   with  the  auditors  the  auditors'
independence.

         We have  considered  whether  the non audit  services  provided  by the
independent  public  accountants  are  compatible  with  maintaining  the public
accountants' independence.

         Based on the reviews and discussions referred to above, we recommend to
the  Board of  Directors  that the  financial  statements  referred  to above be
included in the Company's Annual Report on Form 10-K for the year ended December
31, 2000.

John E. Bagalay, Jr.
Audit Committee Chairman

Stephen K. Carter
Audit Committee Member

Robert F. Hendrickson
Audit Committee Member

Independent Public Accountants Fees and Other Matters

Audit Fees

         Arthur  Andersen LLP billed the Company an aggregate of $95,500 in fees
for professional services rendered in connection with the audit of the Company's
financial  statements  for the most  recent  fiscal  year and the reviews of the
financial statements included in each of the Company's Quarterly Reports on Form
10-Q during the fiscal year ended December 31, 2000.


                                       5



Financial Information Systems Design and Implementation Fees

         Arthur Andersen LLP did not perform any  professional  services for the
Company  and its  affiliates  for the fiscal  year ended  December  31,  2000 in
connection  with financial  information  systems design or  implementation,  the
operation of the  Company's  information  system or the  management of its local
area network.

All Other Fees

         Arthur  Andersen  LLP billed the Company  $128,425  for other  services
rendered for the most recent fiscal year.

Directors' Compensation

         Each non-employee Director of the Company is paid an annual retainer of
$8,000, plus $1,000 for each Board meeting attended ($500 if participation is by
telephone). Any non-employee Director who also chairs a Board committee receives
an additional annual fee of $1,000. Non-employee Directors receive $250 for each
committee  meeting  attended,  but receive no additional  retainer for committee
membership.  Members of the Nominating Committee do not receive any compensation
for serving on that committee. The Chairman of the Board (who is not an employee
of the Company) currently receives, based upon significant time spent on Company
business,  an additional  annual  retainer of $50,000.  The additional  retainer
contemplates four days per month  substantially given to Company business by the
Chairman.  An amount of $1,500 per day is paid to the  Chairman  for  additional
days in which the  significant  part of the day is devoted  to Company  matters.
During 2000,  the Chairman  was paid his base annual  retainer of $50,000  under
this arrangement.

         Pursuant to the Director Plan, each  non-employee  Director receives an
initial grant of options on the date of appointment  equal to a pro-rata portion
of 10,000 shares of the Company's Common Stock,  based upon the number of months
remaining  from the date of  election  until  the one  year  anniversary  of the
preceding  annual  meeting.  In  addition,  on the day  following  each  Cytogen
Corporation Annual Meeting of Stockholders,  each individual who is elected as a
non-employee  Director shall automatically be granted options to purchase 10,000
shares of the  Company's  Common  Stock.  The Chairman of the Board,  unless the
Compensation  Committee  determines  otherwise,  receives an additional grant of
15,000 options to purchase  shares of the Company's  Common Stock on the date of
each annual meeting.  Options granted under the Director Plan are exercisable at
a price equal to the average of the high and low sale prices of the Common Stock
as reported on the Nasdaq  Stock  Market on the date of grant,  and vest in full
(i.e.,  first become  exercisable) at the first  anniversary of the option grant
date. Each director's outstanding options also become immediately exercisable in
full: (i) upon the  occurrence of a change of control of the Company;  (ii) upon
death or  disability;  or (iii) upon  resignation  or  retirement  after age 55.
Options  granted under the Director Plan are granted  automatically  and without
the need for  further  action  by the  Company,  the Board of  Directors  or the
Company's stockholders.

         The Company has prepared an amendment  to the Director  Plan that:  (A)
increases  the number of shares of Common  Stock  underlying  automatic  initial
option grants under the Director Plan to new non-employee  Directors from 10,000
to 20,000  shares;  and (B)  amends the  Director  Plan to  provide,  in certain
circumstances,  at the  discretion  of and after  formal  action by the Board of
Directors,  for the issuance of shares of Common Stock  thereunder to Directors,
in lieu of the cash component of Director compensation.  See "Proposed Amendment
to the 1999 Non-Employee Director Stock Option Plan."


                                       6



                      EXECUTIVE OFFICERS AND KEY EMPLOYEES

         The current executive officers of the Company and their respective ages
and positions with the Company are as follows:



                                                             Capacities In                       In Current
             Name                     Age                    Which Served                      Position Since
-------------------------------       ---        --------------------------------------        ---------------
                                                                                        
H. Joseph Reiser, Ph.D.........        54        Director, President and Chief                   August 1998
                                                 Executive Officer

Lawrence R. Hoffman............        46        Vice President and Chief Financial              July 2000
                                                 Officer

Terry Novak....................        44        Vice President of Sales and Marketing           May 2000


Catherine M. Verna, Esq........        36        Vice President, General Counsel and             April 2000
                                                 Corporate Secretary

Michael J. Titus, Ph.D.........        45        Vice President of Operations                    January 2001


         Lawrence  R.  Hoffman  joined  the  Company as Vice President and Chief
Financial  Officer in July 2000. He is responsible  for all financial  reporting
and controls for the Company.  Mr.  Hoffman was  previously  Vice  President and
Chief  Financial  Officer of The Liposome  Company from April 1998 to June 2000,
which was  acquired by Elan  Corporation  plc in May 2000.  Prior to joining The
Liposome Company,  Mr. Hoffman was Vice President and Chief Financial Officer of
IGI, Inc. From April 1988 through July 1997, Mr. Hoffman held various  positions
including Treasurer, Secretary and Acting Principal Financial Officer for Sybron
Chemicals,  Inc. Mr. Hoffman  received a Bachelor of Science in Accounting  from
LaSalle  University,  a Juris Doctor from Temple University School of Law and an
L.L.M. in Taxation from Villanova University.


         Terry  Novak  joined  the  Company  as  Vice  President  of  Sales  and
Marketing,  a newly  created  position,  in May 2000.  Mr.  Novak  was  formerly
employed  with Boron  LePore &  Associates,  a provider of  marketing  and sales
services,  from June 1999 to May 2000,  where he was Senior Vice  President  and
General  Manager.   Previously,   he  was  Executive  Vice  President  at  Algos
Pharmaceutical   Corporation  from  March  1998  to  June  1999,  where  he  was
responsible  for all  commercial  operations.  Additionally,  Mr. Novak was Vice
President  of Sales and  Marketing  for  Innovex,  Inc., a division of Quintiles
Transnational  Corporation from October 1995 to March 1998 and spent 15 years in
various  sales and  marketing  positions  at  Bristol-Myers  Squibb.  He holds a
Bachelor of Science in Biology from Muhlenberg College.

         Catherine M.  Verna,  Esq.,  joined  the  Company  as  Vice  President,
General Counsel and Secretary in April 2000.  Previously,  Ms. Verna was General
Counsel and Chief Financial Officer of ONQuality.com from December 1999 to March
2000.  From March  1998 to  January  2000,  she was Legal  Counsel  at  Amersham
Pharmacia  Biotech,  Inc.,  and from  September  1997 to January  1998 she was a
Consulting  Attorney to SmithKline Beecham  Pharmaceuticals.  Additionally,  Ms.
Verna was a Senior Associate at Buchanan Ingersoll Professional Corporation from
1993 to 1997,  a law  firm,  where  she did work in  mergers  and  acquisitions,
corporate  finance,  and  securities  law  with  an  emphasis  on  biotechnology
companies.  She holds a Bachelor  of Business  Administration,  summa cum laude,
from Temple  University  and Juris  Doctor  from the  University  of  California
Hastings  College of Law.  She is a member of American Bar  Association  and the
Pennsylvania and New Jersey Bar Associations.

         Michael J. Titus,  Ph.D.,  joined the Company in November  1999 as  the
Director of  Regulatory  Affairs and Quality  Assurance and was promoted to Vice
President  of  Operations  in  January  2001.   Dr.  Titus  comes  from  Berwind
Pharmaceutical  Services,  where he was  Director  of  Quality  Assurance  for a
contract manufacturing facility since November 1996. Dr. Titus has approximately
15  years  experience  in  the  industry,   managing  quality,   regulatory  and
manufacturing  functions for biotech and pharmaceutical  firms and has extensive
knowledge of monoclonal  antibodies and  recombinant  protein  development.  Dr.
Titus holds a Bachelor of Science in Biology from Muhlenberg College and a Ph.D.
in Medical Microbiology from The Pennsylvania State University.

                                       7


         The current key employees of AxCell BioSciences Corporation ("AxCell"),
a subsidiary of the Company are as follows:



                                                             Capacities In                       In Current
             Name                     Age                    Which Served                      Position Since
-------------------------------       ---        ------------------------------------      ----------------------
                                                                                           
John D. Rodwell, Ph.D..........        54        President and Chief Technical                   June 1999
                                                 Officer

Brian R. Bullard...............        37        Vice President and Chief Information            January 1999
                                                 Officer


         John D.  Rodwell,  Ph.D.,  President  and Chief  Technical  Officer  of
AxCell,  originally  joined Cytogen  Corporation in September 1981. He served as
Director,  Chemical  Research,  then as Vice President,  Discovery Research from
1984 to 1989,  as Vice  President,  Research and  Development  from 1989 to July
1996, and as Senior Vice President and Chief  Scientific  Officer from July 1996
through June 1999, at which time he assumed full time duties as Acting President
and Chief  Technical  Officer of AxCell and  subsequently  became  President  of
AxCell  BioSciences.  From 1980 to 1981,  Dr.  Rodwell was a Research  Assistant
Professor  and, from 1976 to 1980,  he was a  postdoctoral  fellow,  both in the
Department of Microbiology at the University of Pennsylvania School of Medicine,
where he  currently  is an Adjunct  Associate  Professor  in the  Department  of
Microbiology.  He holds a Bachelor of Arts in Chemistry  from the  University of
Massachusetts,   a  Masters  of  Science  in  Organic   Chemistry   from  Lowell
Technological  Institute  and a Ph.D.  in  Biochemistry  from the  University of
California at Los Angeles.

         Brian R. Bullard  joined  AxCell in January 1999 as Vice  President and
Chief Information  Officer.  Previously,  since 1997, he was with Perkin-Elmer's
life sciences divisions, PE Biosystems,  where as Manager, Data Products, he was
in charge of  scientific  and  market  evaluation  of data in  conjunction  with
Perkin-Elmer's  bioinformatics  software  platform.  Prior to that, from 1996 to
1997, Mr. Bullard was Director of  Bioinformatics,  Development at Gene Logic in
Maryland,  responsible for the biotechnology firm's information technology.  Mr.
Bullard has sixteen years of  information  technology  experience and has held a
number of other  information  technology  positions with firms including Science
and  Technology  Corporation,   OptiMetrics,  Inc.  and  The  Physical  Sciences
Laboratory.

         None of the Company's or AxCell's  executive  officers or key employees
is related to any other  executive  officer,  key  employee,  or Director of the
Company or AxCell. Executive officers of the Company are elected annually by the
Board of  Directors  and serve  until  their  successors  are duly  elected  and
qualified.  Key  employees  of  AxCell  are  elected  annually  by the  Board of
Directors of such  subsidiary and serve until their  successors are duly elected
and qualified.

Section 16(a) Beneficial Ownership Reporting Compliance

         Section 16(a) of the  Securities  Exchange Act of 1934, as amended (the
"Exchange Act"), requires the Company's directors, officers and stockholders who
beneficially own more than 10% of any class of equity  securities of the Company
registered pursuant to Section 12 of the Exchange Act to file initial reports of
ownership  and reports of changes in  ownership  with  respect to the  Company's
equity securities with the Securities and Exchange  Commission (the "SEC").  All
reporting  persons are  required by SEC  regulation  to furnish the Company with
copies of all reports that such reporting  persons file with the SEC pursuant to
Section 16(a).

         Based  solely  on the  Company's  review of the  copies  of such  forms
received  by the  Company  and upon  written  representations  of the  Company's
reporting persons received by the Company,  except as described as follows, each
such  reporting  person has filed all of their  respective  reports  pursuant to
Section 16(a) on a timely basis.

         During the year ended  December 31, 2000,  Terry Novak,  the  Company's
Vice President, Sales and Marketing,  failed to timely file a Form 4 relating to
his purchase of 2,000 shares of the Company's Common Stock on November 17, 2000,
for which he filed a Form 4 on December 12, 2000. Additionally, Mr. Novak failed
to timely  file a Form 3 relating to his  commencement  of  employment  with the


                                       8

Company on May 15, 2000, for which he filed a Form 3 on June 8, 2000. During the
year ended  December 31, 2000,  Catherine M. Verna,  Esq.,  the  Company's  Vice
President,  General  Counsel  and  Secretary,  failed  to  timely  file a Form 3
relating to Ms. Verna's commencement of employment with the Company on April 25,
2000, for which she filed a Form 3 on June 8, 2000.



                                       9




                             EXECUTIVE COMPENSATION

Summary of Compensation in Fiscal 2000, 1999 and 1998

         The  following  Summary   Compensation  Table  sets  forth  information
concerning  compensation for services in all capacities awarded to, earned by or
paid to each person who served as the Company's Chief  Executive  Officer at any
time during 2000 and the four most highly compensated  executive officers of the
Company or AxCell other than the Chief Executive Officer who were serving at the
end of 2000 and whose aggregate cash  compensation  exceeded $100,000 at the end
of 2000  and one  additional  executive  officer  who  would  have  been a named
executive  officer  but for the fact  that such  person  was not  serving  as an
executive  officer at the end of 2000  (collectively,  the  "Named  Executives")
during the years ended December 31, 2000, 1999 and 1998.




                                                      SUMMARY COMPENSATION TABLE

------------------------------------------------------------------------------------------------------------------------------------
                                                                                                    Long-Term
                                                             Annual Compensation(1)                Compensation
                                               --------------------------------------------           Awards
                                                                                  Other             Securities
      Name and Principal                                                          Annual            Underlying          All Other
           Position               Year           Salary          Bonus        Compensation(2)         Options        Compensation(3)
                                                   ($)            ($)               ($)                 (#)                ($)
             (a)                   (b)             (c)            (d)               (e)                 (g)                (i)
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                        
H. Joseph Reiser ..........       2000           299,038         84,000           216,927             100,000             5,959
     President and Chief          1999           275,000         80,000             --                   --               7,005
     Executive Officer            1998            89,903        150,000             --              2,500,000(4)            399
------------------------------------------------------------------------------------------------------------------------------------

John D. Rodwell............       2000           185,192          37,038            --                   --               5,471
      President and Chief         1999           182,654          14,400            --                   --               8,610
      Technical Officer of        1998           203,000            --              --                150,000             8,881
      AxCell
------------------------------------------------------------------------------------------------------------------------------------

Terry Novak(5).............       2000           113,269         42,654             --                175,000               110
      Vice President, Sales
      and Marketing
------------------------------------------------------------------------------------------------------------------------------------

Richard Krawiec(6).........       2000           134,616            --            179,870              50,000            14,807
      Vice President,
      Investor Relations and
      Corporate Communications
------------------------------------------------------------------------------------------------------------------------------------

Lawrence R. Hoffman(7).....       2000            90,673         40,000             --                550,000               129
      Vice President and
      Chief Financial Officer
------------------------------------------------------------------------------------------------------------------------------------

Nicholas Borys(8)..........       2000           165,000            --              --                 50,000             3,072
      Vice President, Medical
      Affairs




(1)  Certain  perquisites or personal  benefits are not included  herein because
     they did not  exceed,  in the case of each Named  Executive,  the lesser of
     either  $50,000 or 10% of total  annual  salary and bonus  reported for the
     Named Executives.



                                       10



(2)  The amounts disclosed in this column consist of relocation expenses.

(3)  The amounts disclosed in this column include amounts contributed or accrued
     by the Company in the respective  fiscal years under the Company's  Savings
     Plan, a defined  contribution plan which consists of a 401(k) portion and a
     discretionary contribution portion. In fiscal year 2000, these amounts were
     as follows:  on behalf of Dr. Reiser,  $5,250;  Dr.  Rodwell,  $5,100;  Dr.
     Krawiec,  $4,038; and Dr. Borys, $2,925. The amounts disclosed also include
     insurance  premiums  paid by the  Company  with  respect to group term life
     insurance  and with  respect to fiscal  year 2000,  these  amounts  were as
     follows: on behalf of Dr. Reiser, $709; Dr. Rodwell, $371; Mr. Novak, $110;
     Dr.  Krawiec,  $239; Mr.  Hoffman,  $129; and Dr. Borys,  $147. The amounts
     disclosed  also include a severance  payment made to Dr. Krawiec in 2001 of
     $10,769.

(4)  Pursuant to Dr. Reiser's Employment  Agreement,  the Company granted to Dr.
     Reiser an option to purchase up to  2,250,000  shares of Common Stock at an
     exercise price of $1.0937 per share. The remaining vesting schedule of such
     options as of March 31, 2001 is as follows:  (a) 900,000  options  began to
     vest upon  commencement of employment;  (b) 1,125,000 options began to vest
     upon completion of certain performance  objectives,  to the satisfaction of
     the Board of Directors; and (c) 225,000 options will begin to vest upon the
     completion of additional  performance objectives to the satisfaction of the
     Board of Directors.

(5)  Mr. Novak joined the Company as Vice President,  Sales and Marketing in May
     2000.  Amount of bonus  includes:  (a) a $20,000  sign-on bonus;  and (b) a
     $22,654  year-end bonus,  half of which was paid through the grant of 4,841
     shares of Common Stock valued at $2.34 per share,  the fair market value of
     the Common Stock as of December 29, 2000.

(6)  Dr. Krawiec joined the Company as Vice  President,  Investor  Relations and
     Corporate  Communications  in January 2000. Dr. Krawiec left the Company in
     January 2001.

(7)  Mr.  Hoffman  joined the  Company  as Vice  President  and Chief  Financial
     Officer in July 2000.  Amount of bonus includes:  a $40,000 year-end bonus,
     half of which was paid  through the grant of 8,547  shares of Common  Stock
     valued at $2.34 per share,  the fair market value of the Common Stock as of
     December 29, 2000.

(8)  Dr. Borys joined the Company as Vice President,  Medical Affairs in January
     2000. Dr. Borys left the Company in November 2000.



                                       11



Option Grants in 2000

         The following table sets forth information concerning individual grants
of stock options made during 2000 to each of the Named Executives.



                                               OPTION GRANTS IN LAST FISCAL YEAR

-----------------------------------------------------------------------------------------------------------------------
                                      Individual Grant

-----------------------------------------------------------------------------------------------------------------------
                                                                                                Potential Realizable
                                                  Percent of                                           Value at
                                   Number of        Total                                       Assumed Annual Rates
                                   Securities      Options                                             of Stock
                                   Underlying     Granted to                                   Price Appreciation for
                                    Options       Employees      Exercise or                        Option Term (3)
                                    Granted       in Fiscal      Base Price     Expiration   --------------------------
             Name                     (#)          Year(1)      ($/share)(2)       Date         5%($)         10%($)
              (a)                     (b)            (c)            (d)            (e)           (f)           (g)
-----------------------------------------------------------------------------------------------------------------------

                                                                                          
H. Joseph Reiser.............        100,000          6.7            2.91        12/19/10       182,788       463,221

John D. Rodwell..............           --             --             --            --             --            --

Terry Novak..................         95,000          6.3            5.81        05/15/10       347,298       880,120
                                      80,000          5.3            2.91        12/19/10       146,231       370,577

Richard Krawiec(4)...........         50,000          3.3            2.84        04/03/01         7,110        14,220

Lawrence R. Hoffman..........        500,000         33.3           10.14        07/10/10     3,188,810     8,081,071
                                      50,000          3.3            2.91        12/19/10        91,394       231,611

Nicholas Borys(5)............         50,000          3.3            5.27        02/01/01        13,165        26,330
-----------


(1)  Based on an aggregate of  1,500,500  options  granted to employees in 2000,
     including options granted to Named Executives.

(2)  The exercise price of all stock options granted during the last fiscal year
     is equal to the average of the high and low sale prices of the Common Stock
     as  reported  on the Nasdaq  National  Market on the  respective  dates the
     options were granted.  Options granted to executive officers generally vest
     over  three  years at the rate of 33.3%  per year  beginning  on the  first
     anniversary  of the date of grant,  subject to  acceleration  under certain
     conditions.  The maximum term of each option  granted is ten years from the
     date of grant.

(3)  These amounts represent certain assumed rates of appreciation  only. Actual
     gains,  if any, on stock option  exercises  and Common  Stock  holdings are
     dependent on the future  performance  of the Common Stock and overall stock
     market conditions. There is no assurance that the amounts reflected will be
     realized.

(4)      Dr. Krawiec left the Company in January 2001.


(5)      Dr. Borys left the Company in November 2000.



                                       12



Aggregated Option Exercises in 2000 and Year End Option Values

         The following table sets forth information  concerning each exercise of
options  during 2000 by each of the Named  Executives  and the year end value of
unexercised in-the-money options.



                                 AGGREGATED OPTION EXERCISES IN LAST FISCAL YEAR
                                         AND FISCAL YEAR END OPTION VALUES

-------------------------------------------------------------------------------------------------------------------------
                                                                               Number of                   Value of
                                                                         Securities Underlying           Unexercised
                                                                              Unexercised                In-the-Money
                                                                               Options at                 Options at
                                        Shares                                   Fiscal                     Fiscal
                                       Acquired                                Year-End                   Year-End(1)
                                          on             Value                    (#)                        ($)
                                       Exercise         Realized              Exercisable/               Exercisable/
             Name                        (#)               ($)               Unexercisable              Unexercisable
              (a)                        (b)               (c)                    (d)                        (e)
-------------------------------------------------------------------------------------------------------------------------

                                                                                         
H. Joseph Reiser................        50,000          1,007,815         775,000 / 1,300,000        968,983 / 1,500,360

John D. Rodwell.................        25,000           407,425            343,100 / 66,400           29,325 / 19,550

Terry Novak.....................          --               --                 -- / 175,000                 -- / --

Richard Krawiec(2)..............          --               --                 -- / 50,000                  -- / --

Lawrence R. Hoffman.............          --               --                 -- / 550,000                 -- / --

Nicholas Borys(3)...............          --               --                   -- / --                    -- / --
----------


(1)  The  dollar  values in this  column  were  calculated  by  determining  the
     difference between the fair market value of the Common Stock underlying the
     options at fiscal year end of $2.344 per share,  and the exercise  price of
     the options.

(2)      Dr. Krawiec left the Company in January 2001.


(3)      Dr. Borys left the Company in November 2000.


Employment   Contracts,   Termination   of  Employment   and   Change-in-Control
Arrangements

         The Company has executed  indemnification  agreements  with each of its
executive  officers  and  directors  pursuant to which the Company has agreed to
indemnify such parties to the full extent  permitted by law,  subject to certain
exceptions, if any such party becomes subject to an action because such party is
a director,  officer,  employee,  agent or fiduciary of the Company. In general,
the Company's employees are covered by confidentiality agreements.


                                       13

         The Company entered into an employment agreement with H. Joseph Reiser,
Ph.D., the Company's  President and Chief Executive Officer,  which provides for
bonuses and vesting of options for the  purchase of shares of Common Stock based
on continued employment and on the achievement of performance objectives defined
by the Board of Directors.  Dr. Reiser is also entitled to one year's  severance
pay equal to his base salary,  along with medical and insurance benefits for the
same period, if he is dismissed for reasons other than cause.

Compensation Committee Interlocks And Insider Participation

         During 2000, the Company's  Compensation  Committee consisted of Robert
F. Hendrickson,  who served as Chairman,  and S. Leslie Misrock.  Kevin G. Lokay
joined the  Compensation  Committee in 2001. There are no, and during 2000 there
were no, Compensation  Committee  interlocks.  In June 1999, the Company entered
into an agreement with S. Leslie Misrock,  and others,  to reacquire  rights for
immunotherapy to its PSMA technology by acquiring Prostagen,  Inc., of which Mr.
Misrock  was a  principal  holder.  Mr.  Misrock  was  elected  to the  Board of
Directors of the Company in August 1999. In connection with the acquisition, Mr.
Misrock  received  shares of the Company's  Common  Stock.  The Company may also
issue additional shares upon completion of certain  objectives,  including up to
450,000 shares of the Company's Common Stock upon the  satisfactory  termination
of lease obligations assumed in the acquisition;  up to 500,000 shares of Common
Stock upon beneficial resolution of other contractual  arrangements entered into
by Prostagen;  and up to an  additional  $4.0 million in shares of the Company's
Common Stock  (calculated  at the time of issuance)  if certain  milestones  are
achieved in  development  of the PSMA  technology.  Mr.  Misrock would receive a
portion of these shares.

         In addition,  Mr. Misrock is a senior partner at Pennie and Edmonds,  a
New York based  intellectual  property law firm that  represents  the Company on
certain intellectual property matters.



                                       14



Performance Graph

         The following graph compares the cumulative total stockholder return on
the  Company's  Common  Stock  with the  cumulative  total  return on the Nasdaq
Composite Index and the Nasdaq  Pharmaceutical Index  (capitalization  weighted)
for a five year period (January 1, 1996 through December 31, 2000).

                 COMPARISON OF CUMULATIVE TOTAL RETURN(1)(2)(3)

              Among the Company, the Nasdaq Composite Index and the
                           Nasdaq Pharmaceutical Index
                            (Capitalization Weighted)


                           [LINE GRAPH APPEARS HERE]





                  Base
                 Period
 Company/        January      December     December    December     December    December
Index Name       1, 1996        1996         1997        1998         1999        2000
-----------      -------      --------     -------     -------      -------     -------
                                                              
   CYTO            $100       $104.76      $ 30.95     $ 16.07      $ 33.33     $ 30.12
  NASDAQ           $100       $123.05      $150.70     $212.52      $394.94     $237.63
NASDAQ PHAR        $100       $100.31      $103.66     $131.96      $248.03     $308.51
-----------



(1)      Graph assumes $100 invested on January 1, 1996 in the Company's Common
         Stock, the Nasdaq Composite Index and the Nasdaq  Pharmaceutical Index
         (capitalization weighted).

(2)      Total return assumes reinvestment of dividends.

(3)      Year ended December 31.



                                       15


Report of the Compensation Committee of the Board of Directors

Policy

         The Compensation Committee of the Board of Directors (the "Compensation
Committee") is responsible for oversight of the Company's executive compensation
program.  The  Compensation  Committee  is  composed  entirely  of  independent,
non-employee directors.  The Compensation Committee makes recommendations to the
full Board of Directors on compensation  policy and as to specific  compensation
actions,  except  where  independent  action by the  Compensation  Committee  is
appropriate.

         The Company's  compensation program, both for its executive officers as
well as for all employees,  is based on the philosophy that the interests of the
employees  should be closely  aligned with those of the Company's  stockholders.
The 2000 executive compensation program was based on the following principles:

          -    compensation  opportunities should attract the best talent to the
               Company, motivate individuals to perform at their highest levels,
               reward  outstanding  achievement,  and retain the  leadership and
               skills necessary for building long-term stockholder value;

          -    a portion of total compensation should be at risk of performance;
               and

          -    individual  executives  should be  encouraged  to manage from the
               perspective of owners of the Company.

         The Company's  2000  compensation  program  reflected the  Compensation
Committee's  assessment as to appropriate  treatment on an individual  basis for
the Chief Executive Officer and the other Named Executives compared to the prior
year levels. The Company targets its overall  compensation program at the median
level of the  biotechnology  industry.  In addition,  compensation for the Named
Executives (and other executives),  including the Chief Executive Officer,  took
into  account  individual  responsibility  and  performance  as  assessed by the
Compensation Committee.

         The  compensation  program  includes a combination of competitive  base
salary and benefits,  annual cash bonus  opportunities  and stock option awards.
The 2000  executive  compensation  program and a specific  discussion  as to the
compensation of the Chief Executive Officer are set out below.

Annual Compensation for 2000

         Generally,   annual   compensation  of  executive  officers  under  the
executive   compensation   program  for  2000  consisted  of  salary  and  bonus
components.

Base Salary

         In  December   1999,   the   Compensation   Committee   determined  for
recommendation  to the  full  Board  of  Directors,  base  salaries  and  annual
incentive  opportunities  for  2000  for its  executives,  including  the  Chief
Executive Officer and the other Named Executives.

Bonus

         A portion of 2000 executive officer annual compensation opportunity was
based  on  corporate  performance.  The  Compensation  Committee  believes  that
incentive  compensation  should be linked to  corporate  financial  results  and
corporate  goals.  Bonus  opportunity  levels for 2000  performance  were set in
advance of the year at a percentage of base salary, with the total amount of the
bonus  opportunity  dependent on the extent to which  corporate  objectives were
achieved and the amount of cash  available  as  determined  by the  Compensation
Committee.  At year-end,  the  Compensation  Committee  determined the extent to
which the financial  and  corporate  objectives of the Company had been achieved
and applied the  appropriate  bonus  percentage to the respective base salary of



                                       16

each  of  the  Named  Executives.  The  amounts  approved  on  the  Compensation
Committee's recommendations were less than target amounts. The Company issued to
each of Mr. Novak and Mr. Hoffman,  4,841 and 8,547 registered  shares of Common
Stock, respectively, as part of each such individual's 2000 bonus compensation.

Long Term Compensation - Stock Options

         The  Compensation   Committee   believes  that  stock  options  are  an
appropriate  means to link its employees'  interests with those of the Company's
stockholders.  Stock  option  awards are designed  primarily  to provide  strong
incentives for superior  longer-term  performance and continued retention by the
Company.  Because the Compensation Committee believes that corporate performance
is one of the principal  factors  influencing  the market value of the Company's
Common  Stock,  the granting of stock options to executive  officers  encourages
them  to work to  achieve  consistent  improvements  in  corporate  performance.
Options only have value to the recipient when the price of the Company's  Common
Stock exceeds the exercise  price,  which is not less than the fair market value
of the Common Stock at the date of grant.

         Option  grants are set taking into account the  comparison of practices
at peer groups,  an  individual's  level of  responsibility  and  furtherance of
corporate objectives,  and the amount and terms of past stock option awards. The
Compensation Committee also took into account in its review of option grants the
fact that the Company has no other long term  incentive  program,  and  believes
that options are important to retain  executives and promote steps to build long
term value.

Compensation of the Chief Executive Officer

         Dr.  Reiser's  salary  for  2000 was set on the  recommendation  of the
Compensation  Committee  and was  believed  to be an  appropriate  level of base
compensation in view of compensation levels paid by the industry, in view of Dr.
Reiser's  experience,  and  considering  the continuing  accomplishments  of the
Company under his  leadership  during the year. The year end bonus in the amount
of $84,000 was based on the Compensation  Committee's judgment as to achievement
of his objectives compared to a target amount set by the Compensation  Committee
in advance of the year.

Federal Income Tax Considerations

         Section  162(m) of the Internal  Revenue Code of 1986,  as amended (the
"Code")  generally  disallows a federal income tax deduction to public companies
for certain compensation over $1 million paid to its chief executive officer and
four other most highly compensated  executive  officers.  Certain  compensation,
including  compensation  based on  performance,  is not subject to this limit if
certain  conditions  are  met,  primarily,  that  the  compensation  is based on
objective  performance  criteria approved by the stockholders.  The compensation
payments  must also be made  pursuant to a plan  administered  by a committee of
outside directors.  The Compensation Committee must certify that the performance
goals were achieved before payments can be awarded.

         The  Compensation  Committee  believes that its executive  compensation
program is consistent  with the  requirements of Section 162(m) of the Code. The
Company's  regular  stock  option  plans under  which  options may be granted to
executive  officers  have been  approved  by the  stockholders  and the  Company
believes such plans should qualify for the exclusion from the deduction  limits.
Base salary,  annual bonuses and certain other compensation amounts disclosed in
the summary  compensation  table do not qualify  for the  exclusion  from the $1
million  limit but such amounts of  compensation  are not expected to exceed the
deduction limits. The Compensation  Committee will consider appropriate steps in
the future,  including  stockholder  approval,  to maintain  deductions  for its
incentive  compensation plans to the greatest extent practical while maintaining
flexibility  to take actions which it deems in the best interests of the Company
and its stockholders but which may result in certain compensation not qualifying
for tax deductions.

         The  Compensation   Committee   believes  that  performance  should  be
rewarded,  that the  financial  interests of the  executive  officers  should be
aligned with the stockholders,  and that compensation should be competitive.  We
have structured compensation at the Company to meet these criteria.

                                    * * * * *

                                       17

         The  foregoing  report on  compensation  is provided  by the  following
outside directors, who constituted the Compensation Committee during 2000. Kevin
G. Lokay  joined  the  Compensation  Committee  in 2001 and  therefore,  did not
participate in the preparation of this report.

                                  Robert F. Hendrickson, Chairman
                                  S. Leslie Misrock, Member



                                       18



         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

         There were, as of April 2, 2001,  approximately 4,319 holders of record
and approximately  54,054 beneficial  holders of the Company's Common Stock. The
following  table  sets forth  certain  information,  as of April 2,  2001,  with
respect to holdings of the  Company's  Common  Stock by (i) each person known by
the Company to be the  beneficial  owner of more than 5% of the total  number of
shares of the Common Stock  outstanding  as of such date,  based upon  currently
available  Schedules  13D and 13G filed with the SEC, (ii) each of the Company's
directors  (which  includes all  nominees) and Named  Executives,  and (iii) all
directors and executive officers as a group.



                                                                   Amount and Nature of
        Name and Address of Beneficial Owner(1)                   Beneficial Ownership(1)     Percent of Class(2)
------------------------------------------------------           ------------------------     -------------------

                                                                                                 
(ii) Directors (which includes all nominees) and Named
     Executives:

     John E. Bagalay, Jr...............................                  151,800(3)                    *

     Stephen K. Carter.................................                   23,200(3)                    *

     James A. Grigsby..................................                  174,983(3)                    *

     Robert F. Hendrickson.............................                   51,200(3)                    *

     Kevin G. Lokay....................................                        0(3)                    *

     S. Leslie Misrock.................................                  748,333(3)                    *

     H. Joseph Reiser..................................                1,084,674(3)                    1.4%

     Nicholas Borys....................................                        0(3)                    *

     Lawrence R. Hoffman...............................                    8,547(3)(4)                 *

     Richard Krawiec...................................                        0(3)                    *

     Terry Novak.......................................                   38,509(3)(4)                 *

     John D. Rodwell...................................                  461,014(3)(4)                 *

(iii)All directors and executive officers as a
     group (14 persons)................................                2,774,337(3)(4)                 3.5%
----------


* Indicates amount is less than 1%.

(1)  Except  as set  forth  in the  footnotes  to  this  table  and  subject  to
     applicable  community  property law, the persons and entities  named in the
     table have sole voting and investment power with respect to all shares.

(2)  Percent of class for each person and all  executive  officers and directors
     as a group is based on  77,406,032  shares of Common Stock  outstanding  on
     April 2, 2001 and includes shares subject to options held by the individual
     or the group, as applicable,  which are  exercisable or become  exercisable
     within 60 days following such date.

(3)  Includes shares of Common Stock which the following  persons have the right
     to acquire upon the exercise of stock  options,  within 60 days of April 2,
     2001, as follows: Dr. Bagalay:  140,800;  Dr. Carter:  20,200; Mr. Grigsby:
     95,533;  Mr.  Hendrickson:   41,200;  Mr.  Misrock:   28,333;  Dr.  Reiser:
     1,075,000; Mr. Hoffman: 0; Mr. Novak: 31,668; and Dr. Rodwell: 393,100.

(4)  Includes  shares of Common Stock awarded under the 2000 Bonus Program which
     were issued April 6, 2001.


                                       19

Certain Relationships and Related Transactions

         The  members of  the Compensation Committee  during 2000 were Robert F.
Hendrickson  (Chairman) and S. Leslie  Misrock.  Neither of these gentlemen were
officers  or  employees  of  the  Company  while  serving  on  the  Compensation
Committee.  For Related Transactions information relating to Mr. Misrock, please
see  "Executive  Compensation -  Compensation  Committee  Interlocks and Insider
Participation."

     PROPOSED AMENDMENT TO THE 1999 NON-EMPLOYEE DIRECTOR STOCK OPTION PLAN

General

         On April 1, 1999,  the Board of  Directors  approved  and,  on June 16,
1999, the stockholders adopted, the 1999 Non-Employee Director Stock Option Plan
(the "Director  Plan").  The Director Plan  currently  provides for the grant of
options to purchase a maximum of 500,000 shares of the Company's Common Stock to
non-employee directors of the Company, of whom there are six.

         The  following  is a summary  description  of the  Director  Plan as it
currently exists without giving effect to the proposed amendment.  The full text
of the Director Plan may be obtained by the Company's  stockholders upon request
to the Office of the Corporate Secretary of the Company.

         Currently,  each person who first becomes a Director of the Company and
who is not also an  employee  or  officer of the  Company,  has been or shall be
granted,  on the date on  which  he or she  became  or will  become a  Director,
whichever is later,  an option to purchase  10,000 shares of Common Stock,  or a
pro-rata  portion  thereof,  based upon the number of full months remaining from
the date of  election  until  the one year  anniversary  month of the  preceding
annual meeting. In addition, each eligible director who is re-elected,  shall be
granted an option to purchase 10,000 shares of Common Stock, and the Chairman of
the Board of Directors,  unless the Compensation Committee determines otherwise,
shall be granted  options to purchase  15,000 shares of Common  Stock.  All such
options  shall have an  exercise  price per share  equal to the then fair market
value of the  shares.  The term of each option will be for a period of ten years
from the date of grant, unless sooner terminated in accordance with the Director
Plan.

         Options may not be transferred except by will or by the laws of descent
and  distribution  and are exercisable to the extent vested at any time prior to
the scheduled expiration date of the option. The Director Plan terminates on the
earlier of June 16, 2009 or at such time as all shares of Common Stock currently
or  hereafter  reserved  for  issuance  shall have been  issued,  unless  sooner
terminated by the Board of Directors.

         In the event that the  Company's  Common Stock shall be  subdivided  or
combined  into a greater or  smaller  number of shares or if the  Company  shall
issue any shares of Common Stock as a stock dividend on its  outstanding  Common
Stock,  the number of shares of Common  Stock  deliverable  upon the exercise of
options  granted  under the Director  Plan shall be  appropriately  increased or
decreased  proportionately,  and  appropriate  adjustments  shall be made in the
purchase  price per share to  reflect  such  subdivision,  combination  or stock
dividend.  In the event that the Company is to be consolidated  with or acquired
by another entity in a merger, sale of all or substantially all of the Company's
assets or  otherwise,  each  option  granted  under the  Director  Plan which is
outstanding  but  unvested as of the  effective  date of such event shall become
fully exercisable.

         The  Director  Plan may be amended or  discontinued  at any time by the
Board of Directors without  stockholder  approval,  but no amendment may be made
without  stockholder  approval which would, among other things, (i) increase the
maximum  number of shares for which  options may be granted  under the  Director
Plan, (ii) materially  modify the  requirements as to eligibility to participate
in the Director Plan, or (iii) materially  increase  benefits accruing to option
holders under the Director Plan. No amendment will affect any option  previously
granted without the consent of the grantee.


                                       20

Federal Income Tax Treatment

         The following discussion is based upon federal tax laws and regulations
in effect on the date of this Proxy Statement,  which are subject to change, and
upon an  interpretation  of the relevant sections of the Code, their legislative
histories and the income tax regulations which interpret  similar  provisions of
the Code. Furthermore, the foregoing is only a general discussion of the federal
income tax  aspects of the  Director  Plan and does not purport to be a complete
description of all federal  income tax aspects of the Director  Plan.  Optionees
may also be subject  to state and local  taxes in  connection  with the grant or
exercise  of  options  granted  under  the  Director  Plan and the sale or other
disposition  of shares  acquired  upon  exercise of the options.  Each  optionee
receiving a grant of options should consult with his or her personal tax advisor
regarding federal, state and local and foreign tax consequences of participating
in the Director Plan.

         The options to be issued under the Director  Plan will be designated as
non-qualified  stock options  ("NQSOs")  which receive no special tax treatment,
but are taxed  pursuant to Section 83 of the Code.  Under the provisions of that
Section,  if an option is granted in connection with the performance of services
and has a "readily  ascertainable  fair market  value" at the time of the grant,
the optionee will be deemed to have received  compensation income in the year of
grant in an amount equal to the excess of the fair market value of the option at
the time of grant over the amount,  if any, paid by the optionee for the option.
However,  a NQSO  generally has "readily  ascertainable  fair market value" only
when the option is actively  traded on an  established  market and when  certain
stringent Code requirements are met.

         If the option does not have a readily  ascertainable  fair market value
at the time of the grant,  the option is not included as compensation  income at
that time. Rather, the optionee realizes ordinary  compensation income only when
the option is exercised and the optionee has become  substantially vested in the
shares  transferred.  The shares are considered to be substantially  vested when
they are either transferable or not subject to a substantial risk of forfeiture.
The amount of ordinary  compensation  income  realized is equal to the excess of
the fair market value of the shares at the time the shares become  substantially
vested over the sum of the exercise  price plus the amount,  if any, paid by the
optionee for the option.

         If a NQSO is exercised  through  payment of the  exercise  price by the
delivery of Common  Stock,  to the extent that the number of shares  received by
the optionee  exceeds the number of shares  surrendered,  ordinary  compensation
income  will be realized  by the  optionee at that time equal to the  difference
between  the fair market  value of such excess  shares and the tax basis of such
excess shares. The Company is generally entitled to a tax deduction with respect
to any  ordinary  compensation  income  recognized  by a  participant  under the
Director Plan. Any such deduction will be subject to the  limitations of Section
162(m) of the Code.

         Once a NQSO is subject to tax as ordinary  compensation  income,  it is
treated as an investment  option or investment shares and becomes subject to the
investment property rules. No gain or loss arises from the exercise of an option
that was taxed at the time of grant.  When the  optionee  disposes of the shares
acquired pursuant to a NQSO, whether taxed at the time of grant or exercise,  or
some other terms, the optionee will recognize  capital gain or loss equal to the
difference  between the amount received for the shares and the optionee's  basis
in the shares.

         Generally,  the  optionee's  basis in the shares  will be the  exercise
price plus the  optionee's  basis in the  option.  The  optionee's  basis in the
option is equal to the sum of the  compensation  income  realized at the time of
grant or exercise,  whichever is applicable, and the amount, if any, paid by the
optionee for the option. In the compensatory option context,  optionees normally
pay nothing for the grant of the option so the basis in the option will  usually
be the amount of ordinary  compensation  income realized at the time of grant or
exercise.  Thus, the  optionee's  basis in the shares will generally be equal to
the exercise price of the option plus the amount of ordinary compensation income
realized by the  optionee.  The capital gain or loss will be  short-term  if the
shares  are  disposed  of within one year  after the  option is  exercised,  and
long-term  if the shares are  disposed of more than one year after the option is
exercised.

         If a NQSO is taxed at the time of grant and  expires or lapses  without
being exercised,  it is treated in the same manner as the lapse of an investment
option.  The lapse is deemed to be a sale or  exchange  of the option on the day
the option  expires or lapses and the amount of income  realized by the optionee
is zero. The optionee  recognizes a capital loss in the amount of the optionee's


                                       21

basis (ordinary  compensation  income realized at the time of the grant plus the
amount,  if any,  paid by the optionee for the option) in the option at the time
of the lapse.  This capital loss is short-term  or  long-term,  depending on the
optionee's holding period in the option.

         If a NQSO is not  taxed at the  time of grant  and  expires  or  lapses
without  being  exercised,   the  optionee  will  have  no  federal  income  tax
consequences unless the optionee paid for the option. In such case, the optionee
would  recognize a capital  loss in the amount of the price paid by the optionee
for the option.  This capital loss is short-term or long-term,  depending on the
optionees holding period in the option.

Previously Granted Options

         As of April 2, 2001,  the Company  had  granted  options to purchase an
aggregate  of 175,666  shares of Common Stock (net of  cancellations)  under the
Director Plan at a weighted  average  exercise  price of $3.38 per share.  As of
April 2, 2001,  116,333 options to purchase shares were vested and no options to
purchase  shares had been exercised under the Director Plan. The following table
sets forth information as of April 2, 2001 concerning  options granted under the
Director  Plan  to (i) the  Named  Executives(1);  (ii)  all  current  executive
officers  as a  group(1);  (iii) all  current  Directors  who are not  executive
officers  as a group;  (iv) each  nominee for  election as a Director;  (v) each
associate of any of such Directors,  executive  officers or nominees;  (vi) each
person who has received or is to receive 5% of such options or rights; and (vii)
all employees, including all current officers who are not executive officers, as
a group(1):



                                            Options Granted
                                                through           Weighted Average
              Name                           April 2, 2001         Exercise Price        Expiration Date
---------------------------------           ---------------       ----------------       ---------------
                                                                                    
James A. Grigsby.................                61,000                 $3.31                6/16/09

John E. Bagalay..................                31,000                 $3.21                6/16/09

Stephen K. Carter................                31,000                 $3.21                6/16/09

Robert F. Hendrickson............                31,000                 $3.21                6/16/09

S. Leslie Misrock................                18,333                 $3.97                8/11/09

Kevin G. Lokay...................                 3,333                 $6.12                1/17/11

H. Joseph Reiser, Ph.D...........                     0                     0                   --

All current directors who are
   not executive officers as a
   group (6 persons).............               175,666                 $3.38                6/16/09
----------


(1)  Participation in the Director Plan is limited to non-employee  Directors of
     the Company,  therefore Named Executives,  executive officers and employees
     of the Company are not eligible to participate.

(2)  As an executive officer, Mr. Reiser is not eligible to participate in the
     Director Plan.

         As of April 2, 2001,  the market value of the Common  Stock  underlying
the Director Plan was $2.98 per share.

Proposed Amendment

         Stockholders are being asked to consider and vote upon the amendment of
the Director Plan: (A) to increase, from 10,000 to 20,000, the number of options
awarded to a new  eligible  director  upon his or her  election  to the Board of
Directors; and (B) to provide, in certain circumstances at the discretion of and
after  formal  action by the Board of  Directors,  for the issuance of shares of
Common  Stock  to the  Directors  in  lieu of the  cash  component  of  Director
compensation.


                                       22

         Under the  proposal,  the number of shares of Common  Stock  underlying
automatic initial option grants to new non-employee Directors under the Director
Plan is increased from 10,000 to 20,000 shares.

         Also under the proposal,  Director's cash  compensation,  including but
not limited to a  Director's  service  fee,  Board  attendance  fees,  committee
attendance  fees  and  fees  payable  for  committees  chaired,  which  fees are
currently  paid in cash,  may be paid in shares of Common Stock,  in whole or in
part,  at the  discretion  of and after formal action by the Board of Directors.
Such shares of Common Stock,  if any,  would be issued under the Director  Plan.
The number of shares so issued  would be based upon the fair market value of the
Common Stock at the time of each such  issuance.  All issued shares would bear a
lock-up legend prohibiting transfer for a one year period of time beginning from
the date of issuance. In the event the Board of Directors elects to exercise its
discretion  to grant  Common  Stock in lieu of cash fees as provided  for by the
proposed  amendment,  and takes formal action  related  thereto,  the payment of
shares  in lieu of such cash  fees  would  cease,  at an  individual  Director's
option,  if either (i) such Director owns 20,000 shares of the Company's  Common
Stock,  excluding all options or other rights to acquire shares of the Company's
Common Stock; or (ii) if fewer than 20,000 shares of Common Stock are owned by a
Director,  such  smaller  number of shares  shall have a fair market value of in
excess of one hundred thousand dollars ($100,000),  excluding the value, if any,
of options to purchase Common Stock,  whether  exercisable or unexercisable,  or
other right to acquire Common Stock of the Company.

         The Board of Directors  believes  that the Director  Plan,  as amended,
would provide  important  inducements  to recruit and retain the best  available
Board members.  The Board of Directors believes that providing directors with an
opportunity  to invest  in the  Company  rewards  them  appropriately  for their
efforts on behalf of the Company.

         The  Board  of  Directors  recommends  a vote FOR the  approval  of the
Director Plan Amendment.

             PROPOSED AMENDMENT TO THE EMPLOYEE STOCK PURCHASE PLAN

General

         The Board of Directors  adopted the Employee  Stock  Purchase Plan (the
"ESPP") in April 1997 and the  stockholders of the Company  approved the ESPP at
the Company's 1997 Annual Meeting of Stockholders. The purpose of the ESPP is to
assist the Company in  attracting  and  retaining  employees by offering  them a
greater  stake in the  Company's  success and a closer  identity with it, and to
encourage  ownership of the Company's stock by employees.  The ESPP accomplishes
these goals by allowing  eligible  employees of the Company and its subsidiaries
an ongoing  opportunity to purchase the Company's  Common Stock through  payroll
deduction at a discounted  price.  The maximum number of shares of the Company's
Common  Stock  available  for purchase  under the ESPP is 500,000,  which may be
subject to adjustment for stock splits, stock dividends and the like.

         The  following  is a  summary  description  of the  ESPP  as it  exists
currently without giving effect to the proposed amendment.  The full text of the
ESPP may be obtained by the Company's stockholders upon request to the Office of
the Corporate Secretary of the Company.

         Eligibility

         Currently,   employees  of  the  Company  and  its  subsidiaries  whose
customary employment is at least twenty (20) hours per week or at least five (5)
months per year are  currently  eligible to  participate  in the ESPP after they
have  completed  12  consecutive  months  of  employment.  Currently,  there are
approximately  33 employees  currently  eligible for  participation in the ESPP.
Participation in the ESPP automatically terminates upon an employee's ceasing to
be an employee of the Company or one of its subsidiaries.

         Participant Contributions

         An  eligible  employee  participates  in the ESPP by  electing  to make
after-tax payroll  contributions in an amount equal to not less than one percent
(1%) and not more  than ten  percent  (10%) of his or her base  compensation.  A
participant's  payroll  contributions to the ESPP are allocated to a bookkeeping
account ("Account") and used to purchase Common Stock on a quarterly basis.



                                       23

         Because the number of shares of Common  Stock  purchased by an eligible
employee is dependent upon the amount such employee  contributes to the ESPP, it
is not possible to  determine  the number of shares of Common Stock that will be
acquired under the ESPP by any one employee or group of employees.

         Purchase of Common Stock

         The ESPP  permits  participants  to purchase  Common Stock at a fifteen
percent (15%) discount from the applicable closing price of the Common Stock (as
described below).  The ESPP operates on a quarterly basis ("Offering  Periods").
Contributions allocated to a participant's Account during an Offering Period are
used to buy shares of Common Stock on the last day of such Offering Period.  The
purchase price of a share of Common Stock under the ESPP will be the lesser of:

         Eighty-five  percent  (85%) of the closing price of the Common Stock on
the Nasdaq National Market on the last business day of the Offering Period; or

         Eighty-five  percent  (85%) of the closing price of the Common Stock on
the Nasdaq National Market on the first business day of the Offering Period.

         Each  participant  is deemed to legally own all shares of Common  Stock
allocated  to his or her Account  and is entitled to exercise  all of the rights
associated  with  ownership  of the  shares,  including  voting,  tendering  and
receiving dividends on, such Common Stock.

         The  Company  may  acquire  Common  Stock  for use  under the ESPP from
authorized  but  unissued  shares,  treasury  shares,  in the open  market or in
privately negotiated transactions. The Company pays all expenses incident to the
operation of the ESPP,  including  the costs of  recordkeeping,  accounting  and
legal fees and the cost of delivery of stock certificates to participants.

         Administration

         An individual or committee,  designated by the Board of Directors  (the
"Administrator"),   has  exclusive   authority  to  administer   the  ESPP.  The
Administrator  is responsible  for  interpreting  the provisions of the ESPP and
making all determinations necessary for the administration of the ESPP.

         Amendment and Termination

         The Board of  Directors  has  authority  to amend the ESPP at any time.
However,  the approval of the Company's  stockholders  currently is required to:
(i) increase the maximum number of shares available for purchase under the ESPP;
(ii)  cause the ESPP to fail the  requirements  of Section  423 of the Code;  or
(iii) modify the ESPP's eligibility.

         The Board of Directors  also has authority to terminate the ESPP at any
time. In any event,  if not earlier  terminated  by the Board of Directors,  the
ESPP will  automatically  terminate when the participants  have purchased all of
the shares of Common Stock available under the ESPP.

         Federal Income Tax Treatment

         The  following  is a summary of the United  States  federal  income tax
consequences  that generally will arise with respect to purchases made under the
ESPP and with respect to the sale of Common Stock acquired under the ESPP.

         In  general,  a  participant  will not  recognize  taxable  income upon
enrolling in the ESPP or upon purchasing shares of Common Stock at the end of an
offering.  Instead,  if a participant sells Common Stock acquired under the ESPP
at a sale price that exceeds the price at which the  participant  purchased  the
Common Stock,  then the participant  will recognize  taxable income in an amount


                                       24

equal to the  excess of the sale  price of the  Common  Stock  over the price at
which the  participant  purchased  the Common  Stock.  A portion of that taxable
income will be ordinary income, and a portion may be capital gain.

         If the  participant  sells the  Common  Stock  more than one year after
acquiring  it and more  than two  years  after  the date on which  the  offering
commenced,  then the participant will be taxed as follows.  If the sale price of
the Common Stock is higher than the price at which the participant purchased the
Common Stock, then the participant will recognize ordinary  compensation  income
in an amount equal to the lesser of:

         (i)  fifteen  percent of the fair market  value of the Common Stock on
              the date the offering commenced; and

         (ii) the excess of the sale price of the Common Stock over the price at
              which the participant purchased the Common Stock.

Any further  income will be  long-term  capital  gain.  If the sale price of the
Common  Stock is less  than the  price at which the  participant  purchased  the
Common Stock,  then the participant will recognize  long-term capital loss in an
amount equal to the excess of the price at which the  participant  purchased the
Common Stock over the sale price of the Common Stock.

         If the  participant  sells  the  Common  Stock  within  one year  after
acquiring  it or within  two  years  after the date the  offering  commenced  (a
"Disqualifying  Disposition"),  then the  participant  will  recognize  ordinary
compensation income in an amount equal to the excess of the fair market value of
the Common Stock on the date that it was  purchased  over the price at which the
participant  purchased the Common Stock.  The  participant  will also  recognize
capital  gain in an amount  equal to the  excess of the sale price of the Common
Stock over the fair  market  value of the  Common  Stock on the date that it was
purchased,  or capital  loss in an amount equal to the excess of the fair market
value of the Common Stock on the date that it was purchased  over the sale price
of the Common Stock.  This capital gain or loss will be a long-term capital gain
or loss if the  participant  has held the  Common  Stock  for more than one year
prior to the date of the sale and will be a  short-term  capital gain or loss if
the participant has held the Common Stock for a shorter period.

         The offering of Common Stock under the ESPP has no tax  consequences to
the Company.  Moreover, in general,  neither the purchase nor the sale of Common
Stock  acquired  under the ESPP will have any tax  consequences  to the  Company
except that the Company will be entitled to a  business-expense  deduction  with
respect to any ordinary  compensation  income  recognized by a participant  upon
making a  Disqualifying  Disposition.  Any such deduction will be subject to the
limitations of Section 162(m) of the Code.

         ESPP Participation

         As of April 2, 2001,  the  employees of the Company  have  purchased an
aggregate of 131,634  shares of Common Stock under the ESPP at an average  price
of $1.38 per share. As of April 2, 2001, 368,366 shares of Common Stock remained
available for purchase  under the terms of the ESPP.  The  following  table sets
forth  the  shares  of Common  Stock  purchased  under the ESPP by (i) the Named
Executives;  (ii) all current executive  officers as a group;  (iii) all current
Directors  who are not executive  officers as a group(1);  (iv) each nominee for
election  as a  Director(2);  (v)  each  associate  of  any of  such  Directors,
executive  officers  or  nominees;  (vi) each  person who has  received or is to
receive 5% of such options or rights;  and (vii) all  employees,  including  all
current officers who are not executive officers, as a group:


                                       25



                                                         Shares Purchased
                                                              through              Weighted Average
                     Name                                  April 2, 2001            Purchase Price
---------------------------------------------            ----------------          ----------------
                                                                                   
H. Joseph Reiser, Ph.D(2)....................                  4,674                     $2.20

John D. Rodwell..............................                    0                         $0

Lawrence R. Hoffman(3).......................                    0                         $0

Richard Krawiec..............................                    0                         $0

Terry Novak(3)...............................                    0                         $0

Nicholas Borys...............................                    0                         $0

All current executive officers as a group
  (6 persons)................................                  4,674                     $2.20

All employees, including all current
  officers who are not executive officers,
  as a group (75 persons)...................                 126,960                     $1.35


        As of April 2, 2001, the market value of the Common Stock available for
issuance under the ESPP was $2.98 per share.

-----------

(1)  Participation  in the ESPP is limited to employees  of the  Company,  under
     terms  and  conditions  as  set  forth  therein.  Therefore,   non-employee
     Directors of the Company are not eligible to participate.

(2)  Other than H.  Joseph  Reiser,  the  Company's  nominees  for  election  as
     Directors are not eligible to participate in the ESPP.

(3)  Not eligible to  participate  in the ESPP pursuant to its current terms and
     conditions as set forth therein.

         Proposed Amendment

         Stockholders  are being  asked to  consider  and vote  upon a  proposed
amendment to the Company's  ESPP to: (A) decrease,  from one year to six months,
the term of service required to be eligible to participate  therein;  and (B) to
delete the current plan requirement for stockholder approval of any modification
of the ESPP with respect to  eligibility  for  participation  in the ESPP.  Such
amendment  would allow  employees  to begin  benefiting  from the ESPP after six
months of  employment  with the  Company  and would  provide  the  Company  with
additional  flexibility  in  tailoring  its benefit  plans to attract and retain
employees.

         Upon approval of the proposal to decrease, from one year to six months,
the term of service  required to be eligible to participate  in the ESPP,  there
will be approximately 74 employees eligible to participate therein.

         The Board of  Directors  believes  that the  ESPP,  as  amended,  would
provide  an  important  inducement  to recruit  and  retain  the best  available
personnel.  The Board of Directors  believes that  providing  employees  with an
opportunity  to invest  in the  Company  rewards  them  appropriately  for their
efforts on behalf of the Company.

         The Board of  Directors  recommends a vote FOR the approval of the ESPP
Amendment.

                      AVAILABILITY OF INDEPENDENT AUDITORS

         The  Company  has  selected  Arthur  Andersen  LLP as  its  independent
auditors for the year ended December 31, 2001.  Arthur  Andersen LLP also served
as independent auditors for 2000. One or more representatives of Arthur Andersen
LLP is  expected  to  attend  the  Meeting  and  have an  opportunity  to make a
statement and respond to appropriate questions from stockholders.


                                       26

                             STOCKHOLDERS' PROPOSALS

         Stockholders who intend to have a proposal  considered for inclusion in
the Company's  proxy  materials for  presentation  at the Company's  2002 Annual
Meeting of  Stockholders  pursuant  to Rule 14a-8  under the  Exchange  Act must
submit the proposal to the Company at its offices at 600 College  Road East,  CN
5308,  Princeton,  New Jersey,  08540,  attention  Catherine M. Verna, Esq., not
later than January 9, 2002.

         Stockholders  who intend to present a proposal at such meeting  without
inclusion of such proposal in the  Company's  proxy  materials  pursuant to Rule
14a-8 under the  Exchange Act are  required to provide  advanced  notice of such
proposal to the Company at the  aforementioned  address not later than March 25,
2002.

         If the Company does not receive notice of a stockholder proposal within
this timeframe, the Company's management will use its discretionary authority to
vote the shares it  represents,  as the Board of  Directors  of the  Company may
recommend.  The Company reserves the right to reject, rule out of order, or take
other appropriate  action with respect to any proposal that does not comply with
these other applicable requirements.

                                  OTHER MATTERS

         The Board of Directors  is not aware of any matter to be presented  for
action at the  Meeting  other than the  matters  referred  to above and does not
intend to bring any other matters before the Meeting.  However, if other matters
should come before the Meeting,  it is intended that holders of the proxies will
vote thereon in their discretion.

                                     GENERAL

         The  accompanying  proxy is  solicited by and on behalf of the Board of
Directors  of the  Company,  whose  notice of meeting is  attached to this Proxy
Statement,  and the  entire  cost  of such  solicitation  will be  borne  by the
Company.

         In  addition  to the use of the  mails,  proxies  may be  solicited  by
personal  interview,  telephone  and telegram by  directors,  officers and other
employees  of the  Company  who  will not be  specially  compensated  for  these
services. The Company will also request that brokers,  nominees,  custodians and
other  fiduciaries  forward  soliciting  materials to the  beneficial  owners of
shares  held  of  record  by  such  brokers,  nominees,   custodians  and  other
fiduciaries.  The Company  will  reimburse  such  persons  for their  reasonable
expenses in connection therewith.

         Certain  information  contained in this Proxy Statement relating to the
occupations  and security  holdings of directors  and officers of the Company is
based upon information received from the individual directors and officers.

         CYTOGEN CORPORATION WILL FURNISH,  WITHOUT CHARGE, A COPY OF ITS REPORT
ON FORM  10-K FOR THE YEAR  ENDED  DECEMBER  31,  2000,  INCLUDING  CONSOLIDATED
FINANCIAL STATEMENTS BUT NOT INCLUDING EXHIBITS,  TO EACH OF ITS STOCKHOLDERS OF
RECORD ON APRIL 23, 2001, AND TO EACH  BENEFICIAL  STOCKHOLDER ON THAT DATE UPON
WRITTEN  REQUEST  MADE TO MS.  CATHERINE  M.  VERNA,  ESQ.,  SECRETARY,  CYTOGEN
CORPORATION,  600 COLLEGE ROAD EAST, CN 5308,  PRINCETON,  NEW JERSEY  08540.  A
REASONABLE FEE WILL BE CHARGED FOR COPIES OF REQUESTED EXHIBITS.

         PLEASE  DATE,   SIGN  AND  RETURN  THE  PROXY  CARD  AT  YOUR  EARLIEST
CONVENIENCE IN THE ENCLOSED RETURN ENVELOPE.  A PROMPT RETURN OF YOUR PROXY CARD
WILL BE APPRECIATED AS IT WILL SAVE THE EXPENSE OF FURTHER MAILINGS.

                                          By Order of the Board of Directors

Princeton, New Jersey                     Catherine M. Verna, Esq.,
May 9, 2001                               Secretary


                                       27





                                   APPENDIX A

                             AUDIT COMMITTEE CHARTER










                               CYTOGEN Corporation

                               Board of Directors
                       Audit and Finance Committee Charter

Purpose

         The Audit and Finance Committee's responsibility is, in connection with
the auditing  function,  to assist the full Board of Directors in the  oversight
responsibilities  related to the  integrity of financial  reporting and business
conduct and the adequacy and  effectiveness of internal  controls and accounting
practices,  and to assure the independence of the Company's public  accountants;
and,  in  connection  with the  finance  function,  to review  and  monitor  the
financial  planning and financial  structure of the Company to  accommodate  the
operating requirements and strategic objectives.

Composition

         The  Audit  and  Finance  Committee  shall  consist  of at least  three
directors  who are free from  relationships  that  might  create a  conflict  of
interest,  impair  their  independence,  or  violate  the  requirements  of  the
exchanges on which the Company's equity securities are traded. Each of the Audit
and Finance Committee members shall be independent. "Independent director" means
a person other than an officer or employee of the company or its subsidiaries or
any  other  individual  having  a  relationship  which,  in the  opinion  of the
Company's  board of directors,  would interfere with the exercise of independent
judgment in carrying  out the  responsibilities  of a  director.  The  following
persons shall not be considered independent:

     (a)  a director who is employed by the corporation or any of its affiliates
          for the current year or any of the past three years;

     (b)  a director who accepts any compensation from the corporation or any of
          its affiliates in excess of $60,000  during the previous  fiscal year,
          other  than   compensation   for  board  service,   benefits  under  a
          tax-qualified retirement plan, or non-discretionary compensation;

     (c)  a director who is a member of the  immediate  family of an  individual
          who is, or has been in any of the past three  years,  employed  by the
          corporation  or  any  of  its  affiliates  as  an  executive  officer.
          Immediate  family  includes  a  person's  spouse,  parents,  children,
          siblings, mother-in-law, father-in-law, brother-in-law, sister-in-law,
          son-in-law,  daughter-in-law,  and anyone who resides in such person's
          home;

     (d)  a director  who is a partner in, or a  controlling  stockholder  or an
          executive  officer of, any for-profit  business  organization to which
          the corporation made, or from which the corporation received, payments
          (other than those arising solely from investments in the corporation's
          securities)   that  exceed  5%  of  the   corporation's   or  business
          organization's consolidated gross revenues for that year, or $200,000,
          whichever is more, in any of the past three years;

     (e)  a director who is employed as an executive of another entity where any
          of the  company's  executives  serve  on  that  entity's  compensation
          committee.

         However, one director who is not independent,  as defined above, and is
not a current  employee or an immediate  family member of such employee,  may be
appointed to the Audit and Finance Committee if the Board, under exceptional and
limited  circumstances,  determines  that  membership  on the Audit and  Finance
Committee by the individual is required by the best interests of the Company and
its  stockholders  and the board  discloses,  in the next annual proxy statement
subsequent to such determination, the nature of the relationship and the reasons
for that determination.

         Each of the Audit and Finance  Committee  members shall be able to read
and understand  fundamental financial statements,  including a company's balance
sheet,  income  statement,  and cash flow statement or will become able to do so
within a reasonable period of time after his or her appointment to the Audit and

                                      A-1

Finance Committee.  At least one member of the Audit and Finance Committee shall
have past employment experience in finance or accounting, requisite professional
certification in accounting,  or any other  comparable  experience or background
which results in the individual's financial  sophistication,  including being or
having been a chief executive  officer,  chief financial officer or other senior
officer with financial oversight responsibilities.

Duties

         The duties of the Audit and Finance Committee shall be as follows:

With respect to the audit function

     -    To review and recommend to the full Board of Directors the appointment
          of the Company's  independent public accountants and to evaluate their
          independence and effectiveness at least annually,  including  ensuring
          its receipt from the outside  auditors of a formal  written  statement
          delineating  all  relationships  between the auditor and the  Company,
          consistent with Independence Standards Board Standard 1. The Audit and
          Finance  Committee  shall be  responsible  for actively  engaging in a
          dialogue with the independent  public  accountants with respect to any
          disclosed  relationships  or services that may impact the  objectivity
          and independence of the independent public accountants and for taking,
          or recommending that the full board take,  appropriate action relative
          to the independence of the independent public accountants.

     -    The independent public accountants have ultimate accountability to the
          Board  of  Directors   and  the  Audit  and  Finance   Committee,   as
          representatives of stockholders,  and the Audit and Finance Committee,
          and  the  Board  of  Directors,  as  the  case  may  be,  act  as  the
          stockholders'    representatives    with   ultimate    authority   and
          responsibility to select,  evaluate,  and, where appropriate,  replace
          the independent  public  accountants or, if deemed  appropriate by the
          Board of Directors,  to nominate the independent public accountants to
          be proposed for stockholder approval in any proxy statement.

     -    To review  significant  issues between  management and the independent
          public  accountants  and  significant  audit  reports,  and to  review
          management responses to audits and to changes,  corrective actions, or
          suggested improvements, in significant accounting and internal control
          practices;

     -    To review the interim  financial  statements  with  management and the
          Company's independent public accountants before filing;

     -    To meet periodically with the independent public accountants,  without
          management present, as to accounting practices and internal controls;

     -    To review and  oversee  the  Company's  policies  for  accounting  and
          internal  controls,  and to review  changes in reporting  practices or
          requirements  of   professional   or  regulatory   authorities  as  to
          accounting and financial reporting;

     -    To review the annual  audit  plan and the terms of  engagement  of the
          independent public accountants;

     -    To review  audited  financial  reports  filed by the  Company  and the
          financial    reporting    process   with   respect   to   management's
          responsibility   for  the  integrity,   accuracy  and  objectivity  of
          financial reporting and accounting;

     -    To oversee the  program  for  compliance  with the  Company's  Code of
          Conduct and to make  recommendations  to the full Board of  Directors,
          with respect to the Code of Conduct and the Company's Legal Compliance
          Plan;

     -    To review material  transactions or relationships  between the Company
          and directors and officers of the Company;

                                      A-2

     -    To review the Company's risk management  programs to assure protection
          of the Company's assets;

     -    To  engage  advisors  or  conduct  such  investigations  as  it  deems
          appropriate in carrying out its duties;

     -    To report to the Board of Directors on its activities;

     -    To report to the stockholders of the Company as may be required by the
          federal securities laws and rules and regulations thereunder as to the
          duties and activities of the Audit and Finance Committee.

With respect to financial activities:

     -    To  review  and make  recommendations  as to the  Company's  financial
          planning and capital structure;

     -    To review commercial and investment banking relationships;

     -    To keep  informed of the  operating  and  financial  condition  of the
          Company and its requirements for funds;

     -    To review and  oversee  financial  arrangements  of the  Company  with
          commercial banks and other financial institutions;

     -    To review and  recommend to the full Board of Directors  the structure
          and  terms  of  external   financing   required  to  achieve   Company
          objectives;

     -    To review  and  recommend  to the full  Board of  Directors  financial
          policies relating to corporate investments; and

     -    To report to the Board of Directors on its activities.

Adopted by the Board of Directors
May 16, 2000


                                      A-3


                                  COMMON STOCK
                               CYTOGEN CORPORATION

               PROXY SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS
            OF THE CORPORATION FOR THE ANNUAL MEETING OF STOCKHOLDERS

         The undersigned hereby constitutes and appoints H. Joseph Reiser and
Catherine M. Verna, and each of them, his or her true and lawful agent and proxy
with full power of substitution in each, to represent and to vote on behalf of
the undersigned all of the shares of Cytogen Corporation (the "Company") which
the undersigned is entitled to vote at the Annual Meeting of Stockholders of the
Company to be held at the Holiday Inn, Route One at Ridge Road, Princeton, New
Jersey at 11:00 A.M., local time, on Tuesday, June 19, 2001, and at any
adjournment or adjournments thereof, upon the following proposals more fully
described in the Notice of Annual Meeting of Stockholders and Proxy Statement
for the Meeting (receipt of which is hereby acknowledged).

         This proxy when properly executed will be voted in the manner directed
herein by the undersigned stockholder. If no direction is made, this proxy will
be voted FOR proposals 1, 2, and 3.

                  (continued and to be signed on reverse side)



                 Please Detach and Mail In the Envelope Provided

[X]  Please mark your votes as in this example.


1.   ELECTION OF   FOR    WITHHELD    Nominees:
     DIRECTORS.    [  ]     [  ]      John E. Bagalay, Jr.     Kevin G. Lokay
                                      Stephen K. Carter        S. Leslie Misrock
                                      James A. Grigsby         H. Joseph Reiser
                                      Robert F. Hendrickson

VOTE FOR all the nominees listed at right;
except vote withheld from the following
nominee(s) (if any).

-----------------------------------------------------

2.   APPROVAL OF  PROPOSAL TO AMEND THE  COMPANY'S  1999  NON-EMPLOYEE  DIRECTOR
     STOCK  OPTION PLAN (THE  "DIRECTOR  PLAN") TO: (A)  INCREASE  THE NUMBER OF
     SHARES OF COMMON STOCK UNDERLYING AUTOMATIC INITIAL OPTION GRANTS UNDER THE
     DIRECTOR PLAN TO NEW  NON-EMPLOYEE  DIRECTORS FROM 10,000 TO 20,000 SHARES;
     AND (B) PROVIDE, IN CERTAIN  CIRCUMSTANCES,  AT THE DISCRETION OF AND AFTER
     FORMAL ACTION BY THE BOARD OF  DIRECTORS,  FOR THE ISSUANCE OF COMMON STOCK
     UNDER THE  DIRECTOR  PLAN TO  DIRECTORS,  IN LIEU OF THE CASH  COMPONENT OF
     DIRECTOR COMPENSATION.
              FOR                  AGAINST              ABSTAIN
              [  ]                   [  ]                 [  ]


3.   APPROVAL OF PROPOSAL TO AMEND THE  COMPANY'S  EMPLOYEE FOR AGAINST  ABSTAIN
     STOCK  PURCHASE  PLAN (THE "ESPP") TO: (A)  DECREASE,  FROM ONE YEAR TO SIX
     MONTHS, THE TERM OF SERVICE REQUIRED TO BE ELIGIBLE TO PARTICIPATE THEREIN;
     AND (B) DELETE THE REQUIREMENT FOR STOCKHOLDER APPROVAL OF ANY MODIFICATION
     OF THE ESPP WITH RESPECT TO ELIGIBILTY FOR PARTICIPATION IN THE ESPP.
              FOR                  AGAINST              ABSTAIN
              [  ]                   [  ]                 [  ]


4.   In his or her  discretion,  the  proxy is  authorized  to vote  upon  other
     matters as may properly come before the Meeting.

             I will               I will not
              [  ]                   [  ]        attend the Meeting.


Please disregard if you have previously provided your consent decision.   [  ]

By  checking  the box to the  right,  I  consent  to future  delivery  of annual
reports,  proxy  statements,  prospectuses  and other  materials and shareholder
communications  electronically  via the  Internet  at a  webpage  which  will be
disclosed to me. I understand that the Company may no longer distribute  printed
materials  to me from any  future  shareholder  meeting  until  such  consent is
revoked. I understand that I may revoke my consent at any time by contacting the
Company's transfer agent, Mellon Investor  Services LLC, Ridgefield Park, NJ and
that costs  normally  associated  with  electronic  delivery,  such as usage and
telephone charges as well as any costs I may incur in printing  doucments,  will
be my responsibility.


PLEASE MARK, SIGN, DATE AND RETURN THIS PROXY CARD PROMPTLY, USING THE ENCLOSED
ENVELOPE.


Signature of Common Stockholder_______________________


Signature of Common Stockholder_______________________       Dated: ____________
                                    IF HELD JOINTLY


Note:    This proxy must be signed exactly as the name appears hereon. When
         shares are held by joint tenants, both should sign. If the signer is a
         corporation, please sign full corporate name by duly authorized
         officer, giving full title as such. If the signer is a partnership,
         please sign in partnership name by authorized person.