SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 ----------------- FORM 11-K ANNUAL REPORT PURSUANT TO SECTION 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934 (Mark One) [ X ] ANNUAL REPORT PURSUANT TO SECTION 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934 [FEE REQUIRED] For the fiscal year ended December 31, 2000 OR [ ] TRANSITION REPORT PURSUANT TO SECTION 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934 [NO FEE REQUIRED] For the transition period from ____________ to ____________ Commission File Number 000-14879 A. Full title of the plan and the address of the plan, if different from that of the issuer named below: CYTOGEN RETIREMENT SAVINGS PLAN B. Name of issuer of the securities held pursuant to the plan and the address of its principal executive office: CYTOGEN CORPORATION 600 COLLEGE ROAD EAST CN-5308 PRINCETON, NJ 08540-5308 (609)750-8200 CYTOGEN RETIREMENT SAVINGS PLAN INDEX TO FINANCIAL STATEMENT AND SCHEDULES DECEMBER 31, 2000 Page No. -------- Required Information....................................................2 Report of Independent Public Accountants................................3 Financial Statements: Statements of net assets available for Plan benefits As of December 31, 2000 and 1999..................................4 Statement of changes in net assets available for Plan benefits For the year ended December 31, 2000..............................5 Notes to financial statements As of December 31, 2000..............................................6 Supplemental Schedules: Schedule H, Part IV, Item i - Schedule of assets held for investment purposes As of December 31, 2000..........................................11 Schedule H, Part IV, Item j - Schedule of non-exempt transactions As of December 31, 2000..........................................12 Schedule 27(b)-Schedule of loans or fixed income obligations As of December 31, 2000..........................................13 Signature..............................................................14 Exhibit 23 - Consent of Independent Accountants........................15 1 REQUIRED INFORMATION 1. Financial Statements and Schedules of the Cytogen Retirement Savings Plan prepared in accordance with the financial reporting requirements of the Employee Retirement Income Security Act of 1974, as amended. Exhibit 23. Consent of Arthur Andersen, Independent Accountants 2 Report of independent public accountants To the Plan Administrator of Cytogen Retirement Savings Plan: We have audited the accompanying statements of net assets available for benefits of Cytogen Retirement Savings Plan ("the Plan") as of December 31, 2000 and 1999, and the related statement of changes in net assets available for benefits, and supplemental schedules, for the year ended December 31, 2000. These financial statements and supplemental schedules are the responsibility of the Plan's management. Our responsibility is to express an opinion on these financial statements based on our audits. We conducted our audits in accordance with auditing standards generally accepted in the United States. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion. In our opinion, the financial statements referred to above present fairly, in all material respects, the net assets available for benefits of the Plan as of December 31, 2000 and 1999, and the changes in its net assets available for benefits, and supplemental schedules, for the year ended December 31, 2000, in conformity with accounting principles generally accepted in the United States. /s/ Arthur Andersen, LLP ------------------------- Philadelphia, Pennsylvania July 23, 2001 3 Cytogen Retirement Savings Plan Statements of net assets available for Plan benefits As of December 31, 2000 and 1999 2000 1999 ------------ ------------ Assets: Investments $ 7,486,678 $ 8,894,047 Participant's contribution receivable 14,553 79,834 Employer contribution receivable 55,909 3,730 Loans receivable - 231 ----------- ----------- Net assets available for plan benefits $ 7,557,140 $ 8,977,842 =========== =========== The accompanying notes are an integral part of these financial statements. 4 Cytogen Retirement Savings Plan Statement of changes in net assets available for Plan benefits For the year ended December 31, 2000 Net assets available for Plan benefits, beginning of year $ 8,977,842 Additions: Investment income- Interest and dividends 631,294 Interest income from loans 2,117 ------------- 633,411 ------------- Contributions- Participant 310,314 Employer 112,496 Rollovers 21,568 ------------- 444,378 ------------- Total additions 1,077,789 ------------- Deductions: Net depreciation in fair value of investments (1,033,631) Benefits paid to participants (1,464,860) ------------- Total deductions (2,498,491) ------------- Net decrease (1,420,702) ------------- Net assets available for Plan benefits, end of year $ 7,557,140 ============= The accompanying notes are an integral part of this financial statement. 5 Cytogen Retirement Savings Plan Notes to financial statements As of December 31, 2000 1. Description of the plan: Organization The Cytogen Retirement Savings Plan (the Plan) is a defined contribution plan for the employees of Cytogen Corporation (the Employer or Company) that was established on December 15, 1986. The Plan is governed by the provisions of the Employee Retirement Income Security Act of 1974 (ERISA), as amended, and is intended to comply with Sections 401(a) and 401(k) of the Internal Revenue Code (IRC). The following description of the Plan provides only general information. Participants should refer to the Plan document for a more complete description of the Plan's provisions. Effective September 1, 1999, Massachusetts Financial Services Company replaced Prudential Mutual Fund Service, Inc. as the Plan's Recordkeeper and Investment Manager. Eligibility Each employee shall become eligible to participate within the Plan as of the date when the employee attains the age of 21 years and has completed one month of service. Administration The Employer designates a person or persons to serve as administrator under the Plan, who shall perform all such duties as are necessary to operate, administer, and manage the Plan. The expenses necessary to administer the Plan shall be borne by the Employer, including necessary professional assistance. Contributions Each active participant may enter into a written salary deferral agreement with the Employer in which the employee may elect to defer an amount from 1 percent to 15 percent of his or her compensation and the Employer shall make a matching contribution in an amount equal to 50 percent of the employee contribution, not to exceed limitations set forth by the Plan. The Employer may also make an annual Employer discretionary contribution under the Plan in an amount that the Employer's Board of Directors shall determine by resolution. The allocation of this discretionary contribution shall be made in the proportion that the compensation paid to each participant during the Plan year bears to the compensation paid to all such participants, subject to limitation set forth by the Plan. The Plan also permits the rollover of cash transferred from other employee benefit plans which are qualified under the IRC. Rollovers of cash are included as part of asset additions in the statement of changes in net assets available for benefits. For the year ended December 31, 2000, rollovers of cash amounted to $21,568. 6 Vesting and forfeitures A participant's interest in the Employer matching contribution is 100 percent vested upon the contribution. A participant's interest in the Employer's discretionary contributions vests over four years of service, at which time it becomes 100 percent vested. Vesting credit shall be given for each year of service, except plan years during which a participant did not complete at least 1,000 hours of service. If a participant terminates employment and is not 100 percent vested, the nonvested portion of the participant's account shall be placed in a separate account and will become a forfeiture upon the date such terminated participant incurs a one-year break in service. These forfeitures shall be used by the Employer to reduce the Employer's contribution. Distributions/Benefits A participant who attains the normal retirement age shall have a vesting percentage of 100 percent. If a participant retires from the active service of the Employer on the normal retirement date, then he or she shall receive a distribution of the entire value of their participant account. A participant who retires from the service of the Employer on account of disability shall have a vesting percentage of 100 percent and shall receive a distribution of the entire value of their participant account. Participant loans All participants in the Plan may obtain a loan secured by the participant's account balance. The amount of all outstanding loans to a participant may not exceed 50 percent of the participant's vested account balance. The loans are made at a rate equivalent to rates charged by a professional lender in a similar circumstance. Loans are repaid in no more than five years, except if the loan is for the purchase of the participant's primary residence, in which case the repayment period may exceed five years. Investment options Prudential Mutual Fund Services, Inc. was the Plan's investment manager from January 1, 1999 through August 31, 1999. The Plan's investment options under the management of Prudential Mutual Fund Services, Inc. were as following: Fund Objective ----------------------------------- ---------------------------------------- Money Market Funds Invests in a broad range of money market instruments. Includes Government Securities Trust, Special and Privileged Funds. Prudential Equity Fund A Invests in stocks, bonds and money Prudential Equity Fund B market investments. Fidelity Equity Income Fund T Prudential Balanced Fund A Prudential Balanced Fund B Fidelity Growth Opportunity Fund T Prudential Government Income Fund A Invests in a broad range of fixed income Prudential Government Income Fund B securities. Putnam Voyager Fund A Invests in stocks and money market Putnam International Growth Fund A instruments. AIM Constellation Fund A Prudential Jennison Growth Fund Invests in growth stocks. 7 Effective as of September 1, 1999, Massachusetts Financial Services Company (the Trustee) was the Plan's investment manager. The Plan's investment options under the management of Massachusetts Financial Services Company include the following: Fund Objective ------------------------------------- -------------------------------------- MFS Emerging Growth Fund Invests in emerging growth companies, foreign and emerging market securities, and derivative securities. MFS Money Market Fund Invests in a broad range of money market instruments. Massachusetts Investor Trust Invests in stocks, foreign and emerging market securities, and derivative securities. Massachusetts Investor Growth Stock Fund Invests in long-term growth companies, foreign and emerging market securities, and derivative securities. MFS Research Fund Invests in a broad range of stocks. MFS Total Return Fund Invests in fixed-income securities, stocks, and derivative securities. MFS High Income Fund Invests in high yield corporate bonds, high yield securities, and foreign and emerging market securities. MFS Capital Opportunities Fund Invests in moderate growth companies, foreign and emerging market securities, and derivative securities. MFS Government Securities Fund Invests in fixed-income government securities and derivatives securities. MFS Global Equity Fund Invests in common stocks and equivalents, foreign and emerging market securities, and derivative securities. MFS Fixed Fund Invests in stable-value investment contracts. Termination As of a participant's termination of employment, they shall be entitled to receive a distribution of their entire vested interest. Such distribution shall be further subject to terms and conditions set forth by the Plan. 2. Summary of significant accounting policies: Basis of accounting The Plan is subject to the provisions of the Employee Retirement Income Security Act of 1974, as amended (ERISA). The accompanying financial statements have been prepared on the accrual basis of accounting, except for distributions that are accounted for on a cash basis in accordance with the AICPA Audit and Accounting Guide entitled "Audits of Employee Benefit Plans." Investments are stated at market value. 8 Use of estimates The preparation of financial statements in conformity with generally accepted accounting principles in the United States requires management to make estimates and assumptions that affect the financial statements and the related disclosures during the reporting period. Actual results could differ from those estimates. New accounting pronouncements The Accounting Standards Executive Committee issued Statement of Position 99-3 Accounting for the Reporting of Certain Defined Contribution Plan Investments and Other Disclosure Matters (SOP) which eliminates the requirements for a defined contribution plan to disclose participant-directed investment programs. The SOP was early adopted for the 1999 financial statements. Valuation of investments Investments represent units in a series of funds managed by the investment manager. The Plan's investment funds are stated at market value, as determined based on market quotes of the underlying assets. Plan expenses All administrative costs associated with the operation of the Plan are paid by the Employer in accordance with the terms of the Plan. 3. Investments: The following table presents the current values of individual assets that represent 5 percent or more of the Plan's net assets available for benefits as of December 31, 2000 and 1999 as follows: Description/Issuer of Investment 2000 1999 ------------------------------------------- ----------- ----------- MFS Emerging Growth Fund $ 808,246 $ 1,112,779 Massachusetts Investor Trust 620,564 487,963 Massachusetts Investor Growth Stock Fund 2,260,178 2,864,003 MFS Research Fund 689,687 927,205 MFS Capital Opportunities Fund 897,482 1,091,311 MFS Government Securities Fund 965,414 1,142,123 MFS Global Equity Fund 398,032 554,073 MFS Fixed Fund 604,113 519,753 4. Tax status: The trust established under the Plan is qualified under the IRC as exempt from federal income taxes. The Plan has received a favorable determination letter from the IRS but has not been updated for the most recent plan amendment. However, the plan administrator and the Plan's tax counsel believe that the Plan is currently designed and being operated in compliance with the applicable requirements of the IRC. Therefore, they believe that the Plan was qualified and the related trust was tax-exempt as of the financial statement date. 9 5. Plan termination: Although it has not expressed any intent to do so, the Company has the right under the Plan to discontinue its contributions at anytime and to terminate the Plan, subject to the provisions of ERISA. In the event of termination, distributions shall be subject to the terms and conditions set forth by the Plan. 6. Distributions/benefits paid to participants: Distributions/benefits paid to participants are generally made on a monthly basis for those requests processed in the previous month. There were no distributions/benefits payable to the participants as of December 31, 2000. 10 Cytogen Retirement Savings Plan Schedule H, Part IV, Item i - Schedule of assets held for investment purposes As of December 31, 2000 Market Description of investment value --------------------------------------------------------- ----------- MFS Emerging Growth Fund $ 808,246 MFS Money Market Fund 40,431 Massachusetts Investor Trust 620,564 Massachusetts Investor Growth Stock Fund 2,260,178 MFS Research Fund 689,687 MFS Total Return Fund 164,373 MFS High Income Fund 37,746 MFS Capital Opportunities Fund 897,482 MFS Government Securities Fund 965,414 MFS Global Equity Fund 398,032 MFS Fixed Fund 604,113 *Participant Loans (interest rates ranging from 6 percent to 9.5 percent) 412 ----------- Total $ 7,486,678 =========== * Represents a party-in-interest. 11 Cytogen Retirement Savings Plan Schedule H, Part IV, Item j - Schedule of non-exempt transactions As of December 31, 2000 Amount Identity of party involved Description of transaction of loan -------------------------- -------------------------------- ------- Cytogen Corporation Deemed interest-free loan to the $15,431 Company dated February 25, 2000, maturity April 14, 2000 Cytogen Corporation Deferred interest-free loan to the $14,782 Company dated April 22, 2000, maturity April 27, 2000 12 Cytogen Retirement Savings Plan ITEM 27(b)-SCHEDULE OF LOANS OR FIXED INCOME OBLIGATIONS AS OF DECEMBER 31, 2000 Original Amount Received During Unpaid Identity and Address Amount the Reporting Year Balance at Description Amount Overdue ---------------------- -------------------- of Obligor of Loan Principal Interest End of year of Loan Principal Interest -------------------- --------- --------- -------- ----------- ----------- --------- -------- James Aiken $3,000 $0 $0 $2,595 8.5% interest, $2,243 $ 352 1050 George St. Apt 19H Beginning February New Brunswick, NJ 08901 23, 1998; 130 bi- weekly payments maturing March 12, 2003 Thomas Balla $8,880 $0 $0 $9,605 9.25% interest, $7,054 $2,551 14 Petunia Drive Beginning April 28, North Brunswick, NJ 08902 1996; 260 bi-weekly payments maturing April 15, 2006 13 SIGNATURE THE PLAN Pursuant to the requirements of the Securities Exchange Act of 1934, the Plan has duly caused this annual report to be signed on its behalf by the undersigned hereunto duly authorized. CYTOGEN RETIREMENT SAVINGS PLAN By: Cytogen Corporation, Plan Administrator Date: July 26, 2001 By: /s/ Catherine M. Verna ------------------------ --------------------------------------- Catherine M. Verna Vice President and General Counsel 14