File No. 333-110040
                                                      Filed under Rule 424(b)(3)


                PROSPECTUS SUPPLEMENT NO. 3 DATED AUGUST 16, 2005


          To the Prospectus dated October 28, 2003, as supplemented by
               Prospectus Supplement No. 1 dated November 6, 2003
             and Prospectus Supplement No. 2 dated November 29, 2004


                               CYTOGEN CORPORATION

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     The information in this Prospectus Supplement No. 3 supplements, and should
be  read  in  conjunction  with,  the  Prospectus  dated  October  28,  2003  as
supplemented  by  Prospectus  Supplement  No.  1  dated  November  6,  2003  and
Prospectus  Supplement No. 2 dated November 29, 2004 of Cytogen  Corporation,  a
Delaware corporation, relating to $60,000,000 in shares of our common stock that
we may offer and sell from time to time.  We will  receive  all of the  proceeds
from any  shares  sold.  The  prospectus  was filed as part of our  registration
statement on Form S-3 (No. 333-110040).

     We are  offering  92,799  shares  of our  common  stock  pursuant  to  this
prospectus supplement and the accompanying prospectus as supplemented.
 
     Our common stock is quoted on the Nasdaq  National  Market under the symbol
"CYTO." On August 10, 2005,  the last reported sale price of our common stock on
the Nasdaq National Market was $4.81 per share.
 
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     Investing  in our common  stock  involves a high degree of risk.  See "Risk
Factors" beginning on page 4 of the prospectus.

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     Neither the  Securities and Exchange  Commission  nor any state  securities
commission has approved or disapproved of these securities or determined if this
prospectus  supplement  is  truthful  or  complete.  Any  representation  to the
contrary is a criminal offense.

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     No dealer,  salesperson or any other person has been authorized to give any
information  or make  any  representations  not  contained  in  this  prospectus
supplement or the prospectus, as previously supplemented, and, if given or made,
the  information  or  representations  must not be relied  upon as  having  been
authorized by us. This prospectus  supplement and the prospectus,  as previously
supplemented,  do not constitute an offer to sell, or a solicitation of an offer
to buy, any securities to any person in any jurisdiction  where such an offer or
solicitation  would  be  unlawful.  Neither  the  delivery  of  this  prospectus
supplement  or the  prospectus,  as previously  supplemented,  nor any sale made
hereunder or thereunder shall,  under any  circumstance,  create any implication
that the  information  contained  herein or  therein  is  correct as of any time
subsequent to the date hereof.





Issuance of Common Stock

     On November 19, 2004, we entered into Addendum No. 2 to the Stock  Exchange
Agreement  dated as of June 15,  1999,  as  amended,  among the  Company and the
stockholders and debtholders of Prostagen,  Inc. Such Addendum  provides that we
will  deliver  such number of shares of our common stock having a value equal to
$500,000 upon the  achievement  of certain  milestones in our prostate  specific
membrane antigen,  or PSMA,  program. We are hereby registering 92,799 shares of
our common stock to be issued to the  stockholders  and debtholders of Prostagen
in connection with the achievement of certain  milestones in our PSMA program as
set forth in  Addendum  No.  2. The  prospectus  provides  for the sale of up to
$60,000,000 in registered shares of our common stock.


                                  THE OFFERING


Common stock offered in this offering:                         92,799 shares


Common stock outstanding before this offering:                 18,683,123 shares


Common stock to be outstanding after this offering:            18,775,922 shares


Nasdaq National Market symbol:                                 CYTO


The  information  above  is based  on  18,683,123  shares  of our  common  stock
outstanding as of August 10, 2005. It does not include:

      o   1,278,226  shares of our common  stock  issuable  upon the exercise of
          stock options  outstanding  as of June 30, 2005 at a weighted  average
          exercise price of $9.37 per share;

 
      o   1,908,122  shares  of  common  stock  issuable  upon the  exercise  of
          warrants  outstanding  as of  June  30,  2005  at a  weighted  average
          exercise price of $11.32 per share; and

 
      o   601,924  shares of common stock  reserved for future  awards under our
          stock incentive plans and stock purchase plan as of June 30, 2005.

 
In June 2005,  the Company  awarded an aggregate of 168,600 shares of restricted
common stock to employees of the Company  pursuant to the terms of the Company's
2004 Stock Incentive Plan. Such restricted  shares are subject to future vesting
and will be issued upon the  satisfaction  of such vesting  provisions and other
terms and conditions related thereto.

                                 August 16, 2005