SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                  SCHEDULE 13G
                                 (Rule 13d-102)

             INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
           TO RULES 13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED
                              PURSUANT TO 13d-2(b)


                          ARENA PHARMACEUTICALS, INC.
--------------------------------------------------------------------------------
                                (Name of Issuer)

                                  COMMON STOCK
--------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                   040047 10 2
--------------------------------------------------------------------------------
                                 (CUSIP Number)

                                December 31, 2001
--------------------------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)

Check the appropriate box to designate the one pursuant to which this Schedule
is filed:

     [ ]       Rule 13d-1(b)

     [ ]       Rule 13d-1(c)

     [X]       Rule 13d-1(d)



/1/ The remainder of this cover page shall be filled out for a reporting
person's initial filing on this with respect to the subject class of securities,
and for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 (the "Act") or otherwise subject to the liabilities of that section of the
Act but shall be subject to all other provisions of the Act (however, see the
Notes).





---------------------                                       --------------------
CUSIP NO. 040047 10 2                 13G                    Page 2 of 15 Pages
---------------------                                       --------------------


--------------------------------------------------------------------------------
   1      NAME OF REPORTING PERSON
          S.S. or I.R.S. Identification No. Of Above Person

          MPM Capital L.P.

--------------------------------------------------------------------------------
   2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                       (a)  [ ]

                                                       (b)  [X]

--------------------------------------------------------------------------------
   3      SEC USE ONLY

--------------------------------------------------------------------------------
   4      CITIZENSHIP OR PLACE OF ORGANIZATION
          Delaware

--------------------------------------------------------------------------------
           NUMBER OF               5    SOLE VOTING POWER
 SHARES BENEFICIALLY OWNED BY           2,074,792 (1)
             EACH
       REPORTING PERSON          -----------------------------------------------
             WITH                  6    SHARED VOTING POWER
                                        None

                                 -----------------------------------------------
                                   7    SOLE DISPOSITIVE POWER
                                        2,074,792 (1)

                                 -----------------------------------------------
                                   8    SHARED DISPOSITIVE POWER
                                        None

--------------------------------------------------------------------------------
   9      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
          2,074,792 (1)

--------------------------------------------------------------------------------
   10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
          [ ]

--------------------------------------------------------------------------------
   11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
          7.52%

--------------------------------------------------------------------------------
   12     TYPE OF REPORTING PERSON*
          PN

--------------------------------------------------------------------------------
          *SEE INSTRUCTIONS BEFORE FILLING OUT!







---------------------                                       --------------------
CUSIP NO. 040047 10 2                 13G                    Page 3 of 15 Pages
---------------------                                       --------------------


--------------------------------------------------------------------------------
   1      NAME OF REPORTING PERSON
          S.S. or I.R.S. Identification No. Of Above Person

          BB BioVentures L.P.

--------------------------------------------------------------------------------
   2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                       (a)  [ ]

                                                       (b)  [X]

--------------------------------------------------------------------------------
   3      SEC USE ONLY

--------------------------------------------------------------------------------
   4      CITIZENSHIP OR PLACE OF ORGANIZATION
          Delaware

--------------------------------------------------------------------------------
           NUMBER OF               5    SOLE VOTING POWER
 SHARES BENEFICIALLY OWNED BY           2,074,792 (1)
             EACH
       REPORTING PERSON          -----------------------------------------------
             WITH                  6    SHARED VOTING POWER
                                        None

                                 -----------------------------------------------
                                   7    SOLE DISPOSITIVE POWER
                                        2,074,792 (1)

                                 -----------------------------------------------
                                   8    SHARED DISPOSITIVE POWER
                                        None

--------------------------------------------------------------------------------
   9      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
          2,074,792 (1)

--------------------------------------------------------------------------------
   10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
          [ ]

--------------------------------------------------------------------------------
   11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
          7.52%

--------------------------------------------------------------------------------
   12     TYPE OF REPORTING PERSON*
          PN

--------------------------------------------------------------------------------
         *SEE INSTRUCTIONS BEFORE FILLING OUT!







---------------------                                       --------------------
CUSIP NO. 040047 10 2                 13G                    Page 4 of 15 Pages
---------------------                                       --------------------


--------------------------------------------------------------------------------
   1      NAME OF REPORTING PERSON
          S.S. or I.R.S. Identification No. Of Above Person

          BAB BioVentures L.P.

--------------------------------------------------------------------------------
   2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                       (a)  [ ]

                                                       (b)  [X]

--------------------------------------------------------------------------------
   3      SEC USE ONLY

--------------------------------------------------------------------------------
   4      CITIZENSHIP OR PLACE OF ORGANIZATION
          Delaware

--------------------------------------------------------------------------------
           NUMBER OF               5    SOLE VOTING POWER
 SHARES BENEFICIALLY OWNED BY           2,074,792 (1)
             EACH
       REPORTING PERSON          -----------------------------------------------
             WITH                  6    SHARED VOTING POWER
                                        None

                                 -----------------------------------------------
                                   7    SOLE DISPOSITIVE POWER
                                        2,074,792 (1)

                                 -----------------------------------------------
                                   8    SHARED DISPOSITIVE POWER
                                        None

--------------------------------------------------------------------------------
   9      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
          2,074,792 (1)

--------------------------------------------------------------------------------
   10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
          [ ]

--------------------------------------------------------------------------------
   11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
          7.52%

--------------------------------------------------------------------------------
   12     TYPE OF REPORTING PERSON*
          PN

--------------------------------------------------------------------------------
         *SEE INSTRUCTIONS BEFORE FILLING OUT!






---------------------                                       --------------------
CUSIP NO. 040047 10 2                 13G                    Page 5 of 15 Pages
---------------------                                       --------------------


--------------------------------------------------------------------------------
   1      NAME OF REPORTING PERSON
          S.S. or I.R.S. Identification No. Of Above Person

          MPM BioVentures Parallel Fund, L.P.

--------------------------------------------------------------------------------
   2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                       (a)  [ ]

                                                       (b)  [X]

--------------------------------------------------------------------------------
   3      SEC USE ONLY

--------------------------------------------------------------------------------
   4      CITIZENSHIP OR PLACE OF ORGANIZATION
          Delaware

--------------------------------------------------------------------------------
           NUMBER OF               5    SOLE VOTING POWER
 SHARES BENEFICIALLY OWNED BY           2,074,792 (1)
             EACH
       REPORTING PERSON          -----------------------------------------------
             WITH                  6    SHARED VOTING POWER
                                        None

                                 -----------------------------------------------
                                   7    SOLE DISPOSITIVE POWER
                                        2,074,792 (1)

                                 -----------------------------------------------
                                   8    SHARED DISPOSITIVE POWER
                                        None

--------------------------------------------------------------------------------
   9      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
          2,074,792 (1)

--------------------------------------------------------------------------------
   10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
          [ ]

--------------------------------------------------------------------------------
   11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
          7.52%

--------------------------------------------------------------------------------
   12     TYPE OF REPORTING PERSON*
          PN

--------------------------------------------------------------------------------
         *SEE INSTRUCTIONS BEFORE FILLING OUT!





---------------------                                       --------------------
CUSIP NO. 040047 10 2                 13G                    Page 6 of 15 Pages
---------------------                                       --------------------


--------------------------------------------------------------------------------
   1      NAME OF REPORTING PERSON
          S.S. or I.R.S. Identification No. Of Above Person

          BAB BioVentures, N.V.

--------------------------------------------------------------------------------
   2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                       (a)  [ ]

                                                       (b)  [X]

--------------------------------------------------------------------------------
   3      SEC USE ONLY

--------------------------------------------------------------------------------
   4      CITIZENSHIP OR PLACE OF ORGANIZATION
          Netherlands Antilles

--------------------------------------------------------------------------------
           NUMBER OF               5    SOLE VOTING POWER
 SHARES BENEFICIALLY OWNED BY           2,074,792 (1)
             EACH
       REPORTING PERSON          -----------------------------------------------
             WITH                  6    SHARED VOTING POWER
                                        None

                                 -----------------------------------------------
                                   7    SOLE DISPOSITIVE POWER
                                        2,074,792 (1)

                                 -----------------------------------------------
                                   8    SHARED DISPOSITIVE POWER
                                        None

--------------------------------------------------------------------------------
   9      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
          2,074,792 (1)

--------------------------------------------------------------------------------
   10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
          [ ]

--------------------------------------------------------------------------------
   11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
          7.52%

--------------------------------------------------------------------------------
   12     TYPE OF REPORTING PERSON*
          CO

--------------------------------------------------------------------------------
         *SEE INSTRUCTIONS BEFORE FILLING OUT!





---------------------                                       --------------------
CUSIP NO. 040047 10 2                 13G                    Page 7 of 15 Pages
---------------------                                       --------------------


--------------------------------------------------------------------------------
   1      NAME OF REPORTING PERSON
          S.S. or I.R.S. Identification No. Of Above Person

          MPM BioVentures I, LP

--------------------------------------------------------------------------------
   2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                       (a)  [ ]

                                                       (b)  [X]

--------------------------------------------------------------------------------
   3      SEC USE ONLY

--------------------------------------------------------------------------------
   4      CITIZENSHIP OR PLACE OF ORGANIZATION
          Delaware

--------------------------------------------------------------------------------
           NUMBER OF               5    SOLE VOTING POWER
 SHARES BENEFICIALLY OWNED BY           2,074,792 (1)
             EACH
       REPORTING PERSON          -----------------------------------------------
             WITH                  6    SHARED VOTING POWER
                                        None

                                 -----------------------------------------------
                                   7    SOLE DISPOSITIVE POWER
                                        2,074,792 (1)

                                 -----------------------------------------------
                                   8    SHARED DISPOSITIVE POWER
                                        None

--------------------------------------------------------------------------------
   9      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
          2,074,792 (1)

--------------------------------------------------------------------------------
   10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
          [ ]

--------------------------------------------------------------------------------
   11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
          7.52%

--------------------------------------------------------------------------------
   12     TYPE OF REPORTING PERSON*
          PN

--------------------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!





---------------------                                       --------------------
CUSIP NO. 040047 10 2                 13G                    Page 8 of 15 Pages
---------------------                                       --------------------


--------------------------------------------------------------------------------
   1      NAME OF REPORTING PERSON
          S.S. or I.R.S. Identification No. Of Above Person

          MPM BioVentures I, LLC

--------------------------------------------------------------------------------
   2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                       (a)  [ ]

                                                       (b)  [X]

--------------------------------------------------------------------------------
   3      SEC USE ONLY

--------------------------------------------------------------------------------
   4      CITIZENSHIP OR PLACE OF ORGANIZATION
          Delaware

--------------------------------------------------------------------------------
           NUMBER OF               5    SOLE VOTING POWER
 SHARES BENEFICIALLY OWNED BY           2,074,792 (1)
             EACH
       REPORTING PERSON          -----------------------------------------------
             WITH                  6    SHARED VOTING POWER
                                        None

                                 -----------------------------------------------
                                   7    SOLE DISPOSITIVE POWER
                                        2,074,792 (1)

                                 -----------------------------------------------
                                   8    SHARED DISPOSITIVE POWER
                                        None

--------------------------------------------------------------------------------
   9      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
          2,074,792 (1)

--------------------------------------------------------------------------------
   10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
          [ ]

--------------------------------------------------------------------------------
   11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
          7.52%

--------------------------------------------------------------------------------
   12     TYPE OF REPORTING PERSON*
          OO

--------------------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!






---------------------                                       --------------------
CUSIP NO. 040047 10 2                 13G                    Page 9 of 15 Pages
---------------------                                       --------------------


--------------------------------------------------------------------------------
   1      NAME OF REPORTING PERSON
          S.S. or I.R.S. Identification No. Of Above Person

          MPM Asset Management LLC

--------------------------------------------------------------------------------
   2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                       (a)  [ ]

                                                       (b)  [X]

--------------------------------------------------------------------------------
   3      SEC USE ONLY

--------------------------------------------------------------------------------
   4      CITIZENSHIP OR PLACE OF ORGANIZATION
          Delaware

--------------------------------------------------------------------------------
           NUMBER OF               5    SOLE VOTING POWER
 SHARES BENEFICIALLY OWNED BY           2,074,792 (1)
             EACH
       REPORTING PERSON          -----------------------------------------------
             WITH                  6    SHARED VOTING POWER
                                        None

                                 -----------------------------------------------
                                   7    SOLE DISPOSITIVE POWER
                                        2,074,792 (1)

                                 -----------------------------------------------
                                   8    SHARED DISPOSITIVE POWER
                                        None

--------------------------------------------------------------------------------
   9      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
          2,074,792 (1)

--------------------------------------------------------------------------------
   10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
          [ ]

--------------------------------------------------------------------------------
   11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
          7.52%

--------------------------------------------------------------------------------
   12     TYPE OF REPORTING PERSON*
          OO

--------------------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!




---------------------                                      ---------------------
CUSIP NO. 040047 10 2                 13G                   Page 10 of 15 Pages
---------------------                                      ---------------------


--------------------------------------------------------------------------------
   1      NAME OF REPORTING PERSON
          S.S. or I.R.S. Identification No. Of Above Person

          Medical Portfolio Management, LLC

--------------------------------------------------------------------------------
   2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                       (a)  [ ]

                                                       (b)  [X]

--------------------------------------------------------------------------------
   3      SEC USE ONLY

--------------------------------------------------------------------------------
   4      CITIZENSHIP OR PLACE OF ORGANIZATION
          Delaware

--------------------------------------------------------------------------------
           NUMBER OF               5    SOLE VOTING POWER
 SHARES BENEFICIALLY OWNED BY           2,074,792 (1)
             EACH
       REPORTING PERSON          -----------------------------------------------
             WITH                  6    SHARED VOTING POWER
                                        None

                                 -----------------------------------------------
                                   7    SOLE DISPOSITIVE POWER
                                        2,074,792 (1)

                                 -----------------------------------------------
                                   8    SHARED DISPOSITIVE POWER
                                        None

--------------------------------------------------------------------------------
   9      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
          2,074,792 (1)

--------------------------------------------------------------------------------
   10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
          [ ]

--------------------------------------------------------------------------------
   11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
          7.52%

--------------------------------------------------------------------------------
   12     TYPE OF REPORTING PERSON*
          OO

--------------------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!





---------------------                                      ---------------------
CUSIP NO. 040047 10 2                 13G                   Page 11 of 15 Pages
---------------------                                      ---------------------


--------------------------------------------------------------------------------
   1      NAME OF REPORTING PERSON
          S.S. or I.R.S. Identification No. Of Above Person

          MPM Asset Management Investors 1998 LLC

--------------------------------------------------------------------------------
   2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                       (a)  [ ]

                                                       (b)  [X]

--------------------------------------------------------------------------------
   3      SEC USE ONLY

--------------------------------------------------------------------------------
   4      CITIZENSHIP OR PLACE OF ORGANIZATION
          Delaware

--------------------------------------------------------------------------------
           NUMBER OF               5    SOLE VOTING POWER
 SHARES BENEFICIALLY OWNED BY           2,074,792 (1)
             EACH
       REPORTING PERSON          -----------------------------------------------
             WITH                  6    SHARED VOTING POWER
                                        None

                                 -----------------------------------------------
                                   7    SOLE DISPOSITIVE POWER
                                        2,074,792 (1)

                                 -----------------------------------------------
                                   8    SHARED DISPOSITIVE POWER
                                        None

--------------------------------------------------------------------------------
   9      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
          2,074,792 (1)

--------------------------------------------------------------------------------
   10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
          [ ]

--------------------------------------------------------------------------------
   11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9
          7.52%

--------------------------------------------------------------------------------
   12     TYPE OF REPORTING PERSON*
          OO

--------------------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!






                            STATEMENT ON SCHEDULE 13G

Item 1(a).     Name of Issuer:
               --------------

               Arena Pharmaceuticals, Inc.

Item 1(b).     Address of Issuer's Principal Executive Offices:
               -----------------------------------------------

               6166 Nancy Ridge Drive, San Diego, CA 92121

Item 2(a).     Names of Person Filing:
               ----------------------

               MPM Capital L.P.
               BB BioVentures L.P.
               BAB BioVentures L.P.
               MPM BioVentures Parallel Fund, L.P.
               BAB BioVentures, N.V.
               MPM BioVentures I L.P.
               MPM BioVentures I LLC
               MPM Asset Management, LLC
               Medical Portfolio Management LLC
               MPM Asset Management 1998 LLC

Item 2(b).     Business Mailing Address for the Person Filing:
               ----------------------------------------------

               c/o MPM Capital L.P.
               111 Huntington Avenue, 31st floor
               Boston, MA 02199

Item 2(c).     Citizenship:
               -----------

               All entities were organized in Delaware, except BAB BioVentures,
               N.V., which was organized in the Netherlands Antilles.

Item 2(d).     Title of Class of Securities:
               ----------------------------

               Common Stock

Item 2(e).     CUSIP Number:
               ------------

               040047 10 2

Item 3.        If this statement is filed pursuant to Rules 13d-1(b), or
               13d-2(b), check whether the person filing is a:
               ----------------------------------------------

               Not Applicable

Item 4.        Ownership:
               ---------

               (a)  Amount Beneficially Owned:

                    2,074,792  (1)






               (b)  Percent of Class Owned:
                    7.52%

               (c)  Number of shares as to which such person has:

                    (i)    sole power to vote or to direct the vote:
                           2,074,792 shares of Common Stock (1)

                    (ii)   shared power to vote or to direct the vote:
                           None

                    (iii)  sole power to dispose or to direct the
                           disposition of:
                           2,074,792 shares of Common Stock (1)

                    (iv)   shared power to dispose or to direct the
                           disposition of:
                           None

Item 5.   Ownership of Five Percent or Less of a Class:
          --------------------------------------------

               Not Applicable

Item 6.   Ownership of More than Five Percent on Behalf of Another Person:
          ---------------------------------------------------------------

               Various persons have the right to receive or the power to direct
               the receipt of dividends from, or the proceeds from the sale of,
               the shares to which this statement relates. No one person's
               interest in such shares is more than five percent of the total
               outstanding stock of the Issuer.

Item 7.   Identification and Classification of the Subsidiary Which Acquired the
          ----------------------------------------------------------------------
          Security Being Reported on By the Parent Holding Company:
          --------------------------------------------------------

               Not Applicable

Item 8.   Identification and Classification of Members of the Group:
          ---------------------------------------------------------

               Not Applicable

Item 9.   Notice of Dissolution of Group:
          ------------------------------

               Not Applicable

Item 10.  Certification:
          -------------

               Not Applicable

/1/  Includes shares held through interests in MPM Capital L.P. ("MPM Capital")
and in entities directly or indirectly controlled by it. MPM Capital is a direct
or indirect parent and or a control person of MPM Asset Management LLC and funds
managed or advised by it and the general partners of such funds. Also includes
shares held through interests in Medical Portfolio Management LLC, the general
partner of MPM Capital. Among the shares included, 1,796,035 shares are held by
BB BioVentures L.P.; 257,172 shares are held by MPM BioVentures Parallel Fund,
L.P.; and 21,585 shares are held by MPM Asset Management Investors 1998 LLC.
Each reporting person herein disclaims beneficial ownership of shares not
directly held by such reporting person.






                                    Signature

     After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

Dated: February 13, 2002



MPM CAPITAL L.P.                             BB BIOVENTURES L.P.

By:  Medical Portfolio Management LLC,       By:    BAB BioVentures L.P.,
     its General Partner                            its General Partner

                                             By:    BAB BioVentures N.V.,
                                                    its General Partner
By:  /s/ Michael Steinmetz
     -------------------------
     Name:  Michael Steinmetz
     Title: Manager                          By:  /s/ Michael Steinmetz
                                                  ------------------------------
                                                  Name:  Michael Steinmetz
                                                  Title: Manager


BAB BIOVENTURES L.P.                         MPM BIOVENTURES PARALLEL FUND, L.P.

By:  BAB BioVentures, N.V.,                  By:  MPM BioVentures I LP,
     its General Partner                          its General Partner

                                             By:  MPM BioVentures I LLC,
By:  /s/ Michael Steinmetz                        its General Partner
     -------------------------
     Name:  Michael Steinmetz
     Title: Manager

                                             By: /s/ Michael Steinmetz
                                                 -------------------------------
                                                  Name:  Michael Steinmetz
                                                  Title: Manager

BAB BIOVENTURES, N.V.                        MPM BIOVENTURES I LP

                                             By:  MPM BioVentures I LLC,
                                                  its General Partner
By:  /s/ Michael Steinmetz
     -----------------------
     Name:  Michael Steinmetz
     Title: Manager                          By: /s/ Michael Steinmetz
                                                 -------------------------------
                                                 Name:  Michael Steinmetz
                                                 Title: Manager





MPM BIOVENTURES I LLC                        MPM ASSET MANAGEMENT LLC



By:  /s/ Michael Steinmetz                   By: /s/ Michael Steinmetz
     ----------------------------                -------------------------------
     Name:  Michael Steinmetz                    Name:  Michael Steinmetz
     Title: Manager                              Title: Manager




MEDICAL PORTFOLIO MANAGEMENT, LLC            MPM ASSET MANAGEMENT 1998 LLC



By:  /s/ Michael Steinmetz                   By: /s/ Michael Steinmetz
     -------------------------------             -------------------------------
     Name:  Michael Steinmetz                    Name:  Michael Steinmetz
     Title: Manager                              Title: Manager