As filed with the Securities and Exchange Commission on February 9, 2007

                                           Registration No. 333-  ________

================================================================================

            UNITED STATES SECURITIES AND EXCHANGE COMMISSION
                        Washington, D.C. 20549
                         ______________________
                                FORM S-8
                          REGISTRATION STATEMENT
                                   UNDER
                        THE SECURITIES ACT OF 1933
                         ______________________

                              ACAMBIS PLC
          (Exact name of registrant as specified in its charter)

          England and Wales                           __________N/A________
   (State or other jurisdiction of                       (I.R.S. Employer
    Incorporation or organization)                   Identification Number.)

                     Peterhouse Technology Park, 100 Fulbourn Road
                          Cambridge, CB1 9PT, United Kingdom
                       (Address of principal executive offices)


                       The Acambis 2006 Deferred Bonus Plan
                              (Full title of the Plan)

                                   David Lawrence
                              Chief Financial Officer
                 Peterhouse Technology Park, 100 Fulbourn Road
                       Cambridge, CB1 9PT, United Kingdom
                                 011-44-1223-275-300
            (Name, address and telephone number of agent for service)

                                    Copy to:
                            Kristian E. Wiggert, Esq.
                             Morrison & Foerster MNP
                    7th Floor, CityPoint, One Ropemaker Street
                         London, EC2Y 9AW, United Kingdom
                               011-44-207-920-4000
                          _______________________________

                          CALCULATION OF REGISTRATION FEE



====================================================================================================================
                                                         Proposed maximum       Proposed maximum        Amount of
                                         Amount to        offering price       aggregate offering      registration
      Title of Securities to be      be registered (1)     per share (3)            price (3)              fee
             Registered
--------------------------------------------------------------------------------------------------------------------
                                                                                               
  Ordinary Shares, nominal value
  10 pence each                    1,000,000 shares (2)       $2.13                $2,130,000            $227.91



(1)  Pursuant to Rule 416(a) under the Securities Act of 1933, as amended
     (the "Securities Act"), this Registration  Statement includes an
     indeterminate number of additional shares which may be offered and
     issued to prevent dilution from stock splits, stock dividends or
     similar transactions as provided in the above-referenced plan.

(2) This total represents the amount of shares to be registered for issuance
    pursuant to the Registrant's 2006 Deferred Bonus Plan.

(3) Estimated solely for the purpose of calculating the registration fee.
    Pursuant to Rule 457(c) and Rule 457(h) under the Securities  Act,  the
    proposed maximum offering  price per share and the proposed maximum
    aggregate offering price have been determined on the basis of the average
    of the high (GBP1.10) and low (GBP1.063) sale prices reported on the
    London Stock Exchange on February 6, 2007. The U.S. dollar amount was
    calculated  using the Noon exchange rate for pounds (GBP1 = $1.9693) as
    reported by the Federal Reserve Bank of New York on February 6, 2007.

================================================================================


                                    PART I
                        INFORMATION REQUIRED IN THE
                          SECTION 10(A) PROSPECTUS


       The documents containing the information specified in this Part I of
Form S-8 (plan information and registrant information and employee plan annual
information) will be sent or given to employees as specified by Securities and
Exchange Commission Rule 428(b)(1).  Such documents need not be filed with the
Securities and Exchange Commission (the  "Commission") either as part of this
Registration Statement or as prospectuses or prospectus supplements pursuant
to Rule 424. These documents and the documents incorporated by reference in
this Registration Statement pursuant to Item 3 of Part II of this Form S-8,
taken together, constitute a prospectus that meets the requirements of
Section 10(a) of the Securities Act of 1933, as amended (the "Securities Act").

                                 PART II
                         INFORMATION REQUIRED IN THE
                           REGISTRATION STATEMENT

Item 3.  Incorporation of Documents by Reference.

         The following documents filed by the Registrant with the Commission
are incorporated by reference herein:

         a.     The Registrant's Annual Report on Form 20-F for the year ended
December 31, 2005,  filed on June 28, 2006,  which includes audited financial
statements for such year.

         b.     All other reports filed by the Registrant  pursuant to
Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended
(the "Exchange Act"), since December 31, 2005.

         c.     The description of the Registrant's Ordinary Shares,  nominal
value 10 pence per share, contained in the Registration Statement on Form F-4,
as filed with the Commission on February 10, 1999 (File No. 333-72077),
including  any  amendment or report filed for the purpose of updating such
description.

       All documents filed by the Registrant pursuant to Sections 13(a), 13(c),
14 and 15(d) of the Exchange  Act after the date of this  Registration
Statement,  and prior to the  filing of a  post-effective  amendment  which
indicates  that all securities  offered hereby have been sold or which
de-registers  all securities then remaining  unsold,  shall be deemed to be
incorporated by reference in this Registration  Statement  and to be a part
hereof from the date of filing of such documents,  except as to any portion of
any future annual or quarterly report to stockholders  or document  that is not
deemed filed under such  provisions.  Any statement  contained in a document
incorporated  by  reference  herein shall be deemed to be modified or
superseded for purposes of this Registration  Statement to the extent that a
statement  contained  herein or in any other  subsequently filed document which
also is or is deemed to be incorporated by reference herein modifies or
supersedes such  statement.  Any statement so modified or superseded shall not
be deemed,  except as so modified or superseded,  to constitute a part
of this Registration Statement.


Item 4.    Description of Securities.

         Not applicable.

Item 5.    Interests of Named Experts and Counsel.

         Not applicable.

Item 6.    Indemnification of Directors and Officers.

Articles 225 and 226 of the Registrant's Articles of Association provide:

"225       Directors and secretaries may be indemnified subject to the Statutes

"Subject  to the  provisions  of the  Statutes,  but  without  prejudice  to any
indemnity  to which the  person  concerned  may  otherwise  be  entitled,  every
director  or other  officer of the Company  (other  than any person  (whether an
officer or not) engaged by the Company as auditor) shall be  indemnified  out of
the assets of the Company against any liability  incurred by him for negligence,
default,  breach of duty or breach of trust in  relation  to the  affairs of the
Company,  provided  that this Article 225 shall be deemed not to provide for, or
entitle  any such person to,  indemnification  to the extent that it would cause
this  Article 225 or any element of it, to be treated as void under the 1985 Act
or otherwise under the Statutes."

"226       Power to purchase and maintain insurance

"Without  prejudice to the  provisions of Article 225, the Directors  shall have
power to purchase and maintain,  at the cost of the Company,  insurance  for, or
for the benefit of, any persons who are or were at any time Directors,  officers
or employees of the Company, or of any other company or undertaking which is (a)
the holding company or parent  undertaking of the Company or (b) a subsidiary or
subsidiary  undertaking  of the  Company  or of such  holding  company or parent
undertaking or any such holding  company or parent  undertaking or subsidiary of
subsidiary undertaking or in which the Company or such holding company or parent
undertaking  or subsidiary or subsidiary  undertaking  has any interest  whether
directly  or  indirectly,  or  who  are or  were  at any  time  trustees  of any
retirement  benefits scheme or employees' share scheme in which employees of the
Company or of any such other company or undertaking  are  interested,  including
(without  prejudice to the  generality of the foregoing)  insurance  against any
liability  incurred  by such  persons in respect of any act or  omission  in the
actual or  purported  execution  and/or  discharge  of their  duties  and/or the
exercise or purported  exercise of their powers and/or  otherwise in relation to
their  duties,  powers or offices in  relation  to the Company or any such other
company or undertaking, retirement benefit scheme or employees' share scheme."

Pursuant  to the  provisions  of Section  310(3) of the  Companies  Act 1985 (as
amended  by the  Companies  Act 1989) the  Company  may  purchase  and  maintain
insurance to indemnify any director, officer, manager or auditor of the Company.
Section  310 of the  Companies  Act  1985  (as  amended  by  Section  137 of the
Companies Act 1989) provides as follows:

"310.      Provisions protecting auditors from liability

                  (1)      This section applies to any provision, whether
contained in a company's articles or in any contract with the company or
otherwise, for exempting any ..... person (whether an officer or not) employed
by the company as auditor from, or indemnifying him against, any liability
which by virtue of any rule of law would otherwise attach to him in respect of
any negligence, default, breach of duty or breach of trust of which he may be
guilty in relation to the company.

                  (2)      Except as provided by the following subsection, any
                           such provision is void.

                  (3)      This section does not prevent a company -

                           (a)     from purchasing and maintaining for any such
...... auditor insurance against any such liability, or

                           (b)     from indemnifying any such ..... auditor
against any liability incurred by him -

                                    (i)     in defending any proceedings
(whether civil or criminal) in which judgment is given in his favour or he is
acquitted, or

                                    (ii)    in connection with any application
under section 727 (general power to grant relief in case of honest and #
reasonable conduct) in which relief is granted to him by the court."


Section 727 of the Companies Act 1985 provides as follows:

"727       Power of court to grant relief in certain cases

                  (1)      If in any proceedings for negligence, default,
breach of duty or breach of trust against an officer of a company or a person
employed by a company as auditor (whether he is or is not an officer of the
company) it appears to the court hearing the case that that officer or person
is or may be liable in respect of the negligence, default, breach of duty or
breach of trust, but that he has acted honestly and reasonably, and that having
regard to all the circumstances of the case (including those connected with his
appointment) he ought fairly to be excused for the negligence, default, breach
of duty or breach of trust, that court may relieve him, either wholly or
partly, from his liability in such terms as it thinks fit.

                  (2)      If any such officer or person as above- mentioned
has reason to apprehend that any claim will or might be made against him in
respect of any negligence, default, breach of duty or breach of trust, he may
apply to the court for relief; and the court on the application has the same
power to relieve him as under this section it would have had if it had been a
court before which proceedings against that person for negligence, default,
breach of duty or breach of trust had been brought.

                  (3)      Where a case to which subsection (1) applies is
being tried by a judge with a jury, the judge, after hearing the evidence,
may, if he is satisfied that the defendant or defender ought in pursuance of
that subsection to be relieved either in whole or in part from the liability
sought to be enforced against him, withdraw the case in whole or in part from
the jury and forthwith direct judgment to be entered for the defendant or
defender on such terms as to costs or otherwise as the judge may think proper."

Item 7.    Exemption From Registration Claimed.

         Not applicable.

Item 8.    Exhibits.

         4.1      Memorandum of Association of Acambis plc(1)

         4.2      Articles of Association of Acambis plc(2)

         5.1      Opinion of Morrison & Foerster MNP

         23.1     Consent of Morrison & Foerster MNP (contained in Exhibit 5.1)

         23.2     Consent of PricewaterhouseCoopers LLP

         24.1     Power of Attorney (see Signature Page)

Item 9.    Undertakings.

         (a)      The undersigned Registrant hereby undertakes:

                  (1) To file, during any period in which offers or sales are
         being made, a post-effective amendment to this Registration Statement
         to include any material information with respect to the plan of
         distribution not previously disclosed in the Registration Statement
         or any material change to such information in the Registration
         Statement.

                   (2) That for the purpose of determining any liability under
         the Securities Act, each such  post-effective amendment shall be
         deemed to be a new registration statement relating to the
         securities offered therein,  and the offering of such securities at
         that time shall be deemed to be the initial bona fide offering thereof.

                  (3) To remove from  registration by means of a post-effective
         amendment any of the securities being registered which remain unsold
         at the termination of the offering.

         (b)      The undersigned  Registrant  hereby  undertakes  that, for
purposes of determining any liability under the Securities Act, each filing of
the Registrant's  annual report pursuant to Section 13(a) or 15(d) of the
Exchange Act and, where applicable, each filing of an employee benefit plan's
annual report pursuant to Section 15(d) of the Exchange Act that is
incorporated by reference in this Registration Statement shall be deemed to be
a new registration statement relating to the securities offered therein,  and
the offering of such securities at that time shall be deemed to be the initial
bona fide offering thereof.

         (c)      Insofar as indemnification for liabilities arising under the
Securities Act may be permitted to directors, officers and controlling persons
of the Registrant pursuant to the foregoing provisions, or otherwise, the
Registrant has been advised that in the opinion of the Commission such
indemnification is against public policy as expressed in the Securities Act and
is, therefore, unenforceable.  In the event that a claim for indemnification
against such liabilities (other than the payment by the Registrant of the
expenses incurred or paid by a director, officer or controlling person of the
Registrant in the successful defense of any action, suit or proceeding) is
asserted by such director, officer or controlling person in connection with the
securities  being  registered, the Registrant will, unless in the opinion of
its counsel the matter has been settled by controlling  precedent, submit to a
court of appropriate jurisdiction the question whether such indemnification
by it is against public policy as expressed in the Securities Act and will be
governed by the final adjudication of such issue.



                                     SIGNATURES

         Pursuant to the requirements of the Securities Act, the Registrant,
Acambis plc, certifies that it has reasonable grounds to believe that it meets
all of the requirements for filing on Form S-8 and has duly caused this
Registration  Statement to be signed on its behalf by the undersigned,
thereunto duly authorized, in the City of Cambridge, England, on February 9,
2007.


                                                      ACAMBIS PLC


                                By:              /s/ David Lawrence____________
                                                     David Lawrence
                                                     Chief Financial Officer




                             POWER OF ATTORNEY

         Each person whose signature  appears below  constitutes  and appoints
Gordon Cameron and David Lawrence, and each of them, as attorneys-in-fact,
each with the power of substitution, for him in any and all capacities, to
sign any and all amendments to this Registration Statement and to file the
same, with exhibits  thereto and other documents in connection  therewith, with
the Securities and Exchange Commission, granting to said attorneys-in-fact,
full power and authority to do and perform each and every act and thing
requisite and necessary to be done in connection therewith, as fully to all
intents and purposes as he might or could do in person, hereby ratifying and
confirming the said  attorney-in-fact or his substitute or substitutes, may
lawfully do or cause to be done by virtue hereof.  Pursuant to the
requirements of the Securities Act, this Registration Statement has been
signed by the following persons in the capacities and on the date indicated.



Signature                                  Title                      Date





                                                                

         /s/ G.B. Cameron                  Chief Executive Officer    February 9, 2007
_____________________________________      and Director
 Gordon Cameron


         /s/ David Lawrence                Chief Financial Officer    February 9, 2007
_____________________________________      and Director
David Lawrence



                                           Non-Executive Director
____________________

Randal Chase





         /s/ Alan Dalby                    Non-Executive Director     February 9, 2007
_____________________________________
Alan Dalby





         /s/ P.J. Fellner                  Non-Executive Director     February 9, 2007
_____________________________________
Peter Fellner





         /s/ William J. Jenkins             Non-Executive Director     February 9, 2007
_____________________________________
William Jenkins





         /s/ Ross Graham                    Non-Executive Director     February 9, 2007
______________________________________
Ross Graham





         /s/ John A. Lambert                Non-Executive Director      February 9, 2007
______________________________________
John Lambert






                                 INDEX TO EXHIBITS



Exhibit
Number            Document
______            ________

4.1               Memorandum of Association of Acambis plc(3)

4.2               New Articles of Association of Acambis plc(4)

5.1               Opinion of Morrison & Foerster MNP

23.1              Consent of Morrison & Foerster MNP (contained in Exhibit 5.1)

23.2              Consent of PricewaterhouseCoopers LLP

24.1              Power of Attorney (see Signature Page)




                                                                    EXHIBIT 5.1

                       OPINION OF MORRISON & FOERSTER MNP

                     [ON MORRISON & FOERSTER MNP LETTERHEAD]

February 9, 2007

Acambis plc
Peterhouse Technology Park
100 Fulbourn Road
Cambridge CB1 9PT
United Kingdom


Re:  The Acambis 2006 Deferred Bonus Plan

Ladies and Gentlemen:

You have requested our opinion with respect to certain matters of English law in
relation  to  the  Registration   Statement  on  Form  S-8  (the   "Registration
Statement")  to be filed by Acambis  plc  ("Acambis")  with the  Securities  and
Exchange  Commission,  in connection with the registration  under the Securities
Act of 1933,  as  amended,  of up to  1,000,000  ordinary  shares of 10p each in
Acambis (the  "Shares")  offered  pursuant to the  provisions  of Acambis'  2006
Deferred  Bonus  Plan (the  "Plan").  As your  English  legal  counsel,  we have
examined the proceedings taken and are familiar with the proceedings proposed to
be taken in connection with the issue of the Shares.

It is our opinion that, upon completion of the proceedings  being taken or to be
taken prior to issue of the Shares, and upon completion of the proceedings being
taken in order to permit such  transactions to be carried out in accordance with
the  securities  laws of the United States and the various  states in the United
States and in the United  Kingdom,  where required,  the Shares,  when issued in
accordance with the terms of the Plan, will be legally and validly issued, fully
paid and non-assessable.

Our  opinions  expressed  above are limited to the laws of England and Wales
and we do not express any opinion  herein  concerning  any other law.

We consent to the filing of this Opinion as an exhibit to the Registration
Statement.


Very truly yours,


/s/ Morrison & Foerster MNP



                                                                    EXHIBIT 23.2




                        [ON PRICEWATERHOUSECOOPERS LETTERHEAD]







            CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM





We  hereby  consent  to the  incorporation  by  reference  in this  Registration
Statement on Form S-8 of Acambis plc of our report dated June 26, 2006  relating
to the principal statements,  which appears in the Annual Report on Form 20-F of
Acambis plc for the year ended December 31, 2005.

/s/ PricewaterhouseCoopers LLP

Cambridge, England
February 9, 2007




(1) Filed as Exhibit 3.1 to the Registrant's Registration Statement on Form F-4,
as filed with the  Commission  on February  10, 1999 (File No.  333-72077),  and
incorporated herein by reference.

(2) Filed as Exhibit 1.2 to the Registrant's  Annual Report on Form 20-F for the
year  ended  December  31,  2004 on June 30,  2005 and  incorporated  herein  by
reference.


(3) Filed as Exhibit 3.1 to the Registrant's Registration Statement on Form F-4,
as filed with the  Commission  on February  10, 1999 (File No.  333-72077),  and
incorporated herein by reference.

(4) Filed as Exhibit 1.2 to the Registrant's  Annual Report on Form 20-F for the
year  ended  December  31,  2004 on June 30,  2005 and  incorporated  herein  by
reference.