PAGE  1
000 B000000 05/31/2012
000 C000000 0001380936
000 D000000 N
000 E000000 NF
000 F000000 Y
000 G000000 N
000 H000000 N
000 I000000 6.1
000 J000000 A
001 A000000 GUGGENHEIM STRATEGIC OPPORTUNITIES FUND
001 B000000 811-21982
001 C000000 6305053700
002 A000000 2455 CORPORATE WEST DRIVE
002 B000000 LISLE
002 C000000 IL
002 D010000 60532
003  000000 N
004  000000 N
005  000000 N
006  000000 N
007 A000000 N
007 B000000  0
007 C010100  1
007 C010200  2
007 C010300  3
007 C010400  4
007 C010500  5
007 C010600  6
007 C010700  7
007 C010800  8
007 C010900  9
007 C011000 10
008 A000001 GUGGENHEIM FUNDS INVESTMENT ADVISORS, LLC
008 B000001 A
008 C000001 801-000000
008 D010001 LISLE
008 D020001 IL
008 D030001 60532
008 A000002 GUGGENHEIM PARTNERS INVESTMENT MANAGEMENT,INC
008 B000002 S
008 C000002 801-000000
008 D010002 SANTA MONICA
008 D020002 CA
008 D030002 90401
010 A000001 GUGGENHEIM FUNDS INVESTMENT ADVISORS, LLC
010 B000001 84-0000000
010 C010001 LISLE
010 C020001 IL
010 C030001 60532
011 A000001 WACHOVIA CAPITAL MARKETS LLC
011 B000001 8-00000000
      PAGE  2
011 C010001 CHARLOTTE
011 C020001 NC
011 C030001 28288
011 A000002 RAYMOND JAMES & ASSOCIATES, INC.
011 B000002 8-00000000
011 C010002 ST. PETERSBURG
011 C020002 FL
011 C030002 33716
012 A000001 COMPUTERSHARE SHAREOWNER SERVICES LLC
012 B000001 84-0000000
012 C010001 PITTSBURGH
012 C020001 PA
012 C030001 15252
013 A000001 ERNST & YOUNG LLP
013 B010001 CHICAGO
013 B020001 IL
013 B030001 60606
015 A000001 THE BANK OF NEW YORK MELLON
015 B000001 C
015 C010001 NEW YORK
015 C020001 NY
015 C030001 10286
015 E010001 X
018  000000 Y
019 A000000 N
019 B000000    0
020 A000001 BARCLAYS CAPITALS
020 B000001 06-1031656
020 C000001    119
020 A000002 SUSQUEHANNA FINANCIAL GROUP INC
020 B000002 UNKNOWN
020 C000002     23
020 A000003 MORGAN STANLEY & CO. INC.
020 B000003 13-2655998
020 C000003     12
020 A000004 STIFEL NICHAOLAS
020 B000004 UNKNOWN
020 C000004      9
020 A000005 BANAMEX S.A.
020 B000005 UNKNOWN
020 C000005      9
020 A000006 JEFFERIES & COMPANY INC.
020 B000006 95-2622900
020 C000006      7
020 A000007 BNP PARIBAS
020 B000007 UNKNOWN
020 C000007      6
020 A000008 JP MORGAN INVT MGMT
020 B000008 13-3200244
020 C000008      2
020 A000009 BAYCREST PARTNER
      PAGE  3
020 B000009 UNKNOWN
020 C000009      2
020 A000010 F&G INSTITUTIONAL TRADING INC
020 B000010 UNKNOWN
020 C000010      2
021  000000      194
022 A000001 BARCLAYS
022 B000001 13-3551367
022 C000001      6288
022 D000001     89651
022 A000002 RBS GREENWICH CAPITAL
022 B000002 UNKNOWN
022 C000002     10721
022 D000002     45237
022 A000003 BANAMEX S.A.
022 B000003 UNKNOWN
022 C000003      4007
022 D000003     46529
022 A000004 CITIGROUP GLOBAL MARKETS
022 B000004 UNKNOWN
022 C000004     11819
022 D000004     28257
022 A000005 MORGAN STANLEY & CO. INC
022 B000005 UNKNOWN
022 C000005      9218
022 D000005     24876
022 A000006 JEFFERIES & COMPANY INC.
022 B000006 95-2622900
022 C000006     11112
022 D000006     18985
022 A000007 FIRST BOSTON CORP
022 B000007 13-5659485
022 C000007      8534
022 D000007     14232
022 A000008 NOMURA
022 B000008 UNKNOWN
022 C000008      7375
022 D000008      9670
022 A000009 WELLS FARGO BANK NA
022 B000009 UNKNOWN
022 C000009      3208
022 D000009     11108
022 A000010 MONTGOMERY SECURITIES
022 B000010 UNKNOWN
022 C000010      8222
022 D000010      1140
023 C000000     264024
023 D000000     474053
024  000000 Y
025 A000001 BARCLAYS BANK PLC
025 C000001 D
      PAGE  4
025 D000001    1018
025 A000002 JP MORGAN CHASE CAPITAL XXV
025 C000002 D
025 D000002    1003
025 A000003 SUSQUEHANNA CAPITAL II
025 C000003 D
025 D000003     683
025 A000004 CITIGROUP COMMERCIAL MORTAGAGE TRUST
025 C000004 D
025 D000004    1213
025 A000005 JP MORGAN CHASE COMMERCIAL MORTGAGE
025 C000005 D
025 D000005    2261
025 A000006 MORGAN STANLEY CAPITAL I
025 C000006 D
025 D000006    2300
025 D000007       0
025 D000008       0
026 A000000 N
026 B000000 Y
026 C000000 N
026 D000000 Y
026 E000000 N
026 F000000 N
026 G010000 N
026 G020000 N
026 H000000 N
027  000000 N
030 A000000      0
030 B000000  0.00
030 C000000  0.00
031 A000000      0
031 B000000      0
032  000000      0
033  000000      0
035  000000      0
036 B000000      0
038  000000      0
042 A000000   0
042 B000000   0
042 C000000   0
042 D000000   0
042 E000000   0
042 F000000   0
042 G000000   0
042 H000000   0
043  000000      0
044  000000      0
045  000000 Y
046  000000 N
047  000000 Y
      PAGE  5
048  000000  1.000
048 A010000        0
048 A020000 0.000
048 B010000        0
048 B020000 0.000
048 C010000        0
048 C020000 0.000
048 D010000        0
048 D020000 0.000
048 E010000        0
048 E020000 0.000
048 F010000        0
048 F020000 0.000
048 G010000        0
048 G020000 0.000
048 H010000        0
048 H020000 0.000
048 I010000        0
048 I020000 0.000
048 J010000        0
048 J020000 0.000
048 K010000        0
048 K020000 0.000
049  000000 N
050  000000 N
051  000000 N
052  000000 N
053 A000000 N
054 A000000 Y
054 B000000 Y
054 C000000 N
054 D000000 N
054 E000000 N
054 F000000 N
054 G000000 N
054 H000000 Y
054 I000000 N
054 J000000 Y
054 K000000 N
054 L000000 N
054 M000000 Y
054 N000000 N
054 O000000 N
055 A000000 N
055 B000000 N
056  000000 N
057  000000 N
058 A000000 N
059  000000 Y
060 A000000 Y
060 B000000 Y
      PAGE  6
061  000000        0
062 A000000 Y
062 B000000   0.0
062 C000000   0.0
062 D000000   0.0
062 E000000   0.0
062 F000000   0.0
062 G000000   0.0
062 H000000   0.0
062 I000000   0.0
062 J000000   0.0
062 K000000   0.1
062 L000000   8.6
062 M000000   0.0
062 N000000   0.0
062 O000000   0.0
062 P000000  43.0
062 Q000000  66.4
062 R000000  23.1
063 A000000   0
063 B000000  8.9
064 A000000 N
064 B000000 N
066 A000000 N
067  000000 N
068 A000000 N
068 B000000 N
069  000000 N
070 A010000 Y
070 A020000 Y
070 B010000 Y
070 B020000 Y
070 C010000 Y
070 C020000 N
070 D010000 Y
070 D020000 Y
070 E010000 Y
070 E020000 N
070 F010000 Y
070 F020000 N
070 G010000 Y
070 G020000 N
070 H010000 Y
070 H020000 N
070 I010000 N
070 I020000 N
070 J010000 Y
070 J020000 Y
070 K010000 Y
070 K020000 Y
070 L010000 Y
      PAGE  7
070 L020000 Y
070 M010000 Y
070 M020000 N
070 N010000 Y
070 N020000 N
070 O010000 Y
070 O020000 Y
070 P010000 Y
070 P020000 N
070 Q010000 N
070 Q020000 N
070 R010000 Y
070 R020000 N
071 A000000    304243
071 B000000    285367
071 C000000    255019
071 D000000  112
072 A000000 12
072 B000000    21802
072 C000000      723
072 D000000        0
072 E000000        0
072 F000000     2658
072 G000000       68
072 H000000        0
072 I000000       21
072 J000000       73
072 K000000        0
072 L000000       71
072 M000000       81
072 N000000       24
072 O000000        0
072 P000000     1430
072 Q000000      131
072 R000000       41
072 S000000       86
072 T000000        0
072 U000000        0
072 V000000        0
072 W000000       94
072 X000000     4778
072 Y000000        0
072 Z000000    17747
072AA000000     3754
072BB000000        0
072CC010000        0
072CC020000    14268
072DD010000    18230
072DD020000        0
072EE000000        0
073 A010000   1.8480
      PAGE  8
073 A020000   0.0000
073 B000000   0.0000
073 C000000   0.0000
074 A000000     1601
074 B000000        0
074 C000000        0
074 D000000   226990
074 E000000     4401
074 F000000      125
074 G000000      130
074 H000000        0
074 I000000    61105
074 J000000      650
074 K000000        0
074 L000000     2259
074 M000000      451
074 N000000   297712
074 O000000     3847
074 P000000      255
074 Q000000    30599
074 R010000    53243
074 R020000        0
074 R030000     2099
074 R040000      323
074 S000000        0
074 T000000   207346
074 U010000    10914
074 U020000        0
074 V010000    19.00
074 V020000     0.00
074 W000000   0.0000
074 X000000    11067
074 Y000000   158096
075 A000000        0
075 B000000   187783
076  000000    21.08
077 A000000 Y
077 B000000 Y
077 C000000 Y
077 D000000 N
077 E000000 N
077 F000000 N
077 G000000 N
077 H000000 N
077 I000000 N
077 J000000 N
077 K000000 N
077 L000000 N
077 M000000 N
077 N000000 N
077 O000000 N
      PAGE  9
077 P000000 N
077 Q010000 N
077 Q020000 N
077 Q030000 N
078  000000 N
080 A000000 ICI MUTUAL INSURANCE CO.
080 C000000     5725
081 A000000 Y
081 B000000   8
082 A000000 N
082 B000000        0
083 A000000 N
083 B000000        0
084 A000000 N
084 B000000        0
085 A000000 Y
085 B000000 N
086 A010000   1596
086 A020000  31009
086 B010000      0
086 B020000      0
086 C010000      0
086 C020000      0
086 D010000      0
086 D020000      0
086 E010000      0
086 E020000      0
086 F010000      0
086 F020000      0
087 A010000 COMMON STOCK
087 A020000 18385X104
087 A030000 GOF
088 A000000 Y
088 B000000 N
088 C000000 N
088 D000000 N
SIGNATURE   JOHN SULLIVAN
TITLE       CFO, CAO & TREASURER