--------------------------------------------------------------------------------

                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549





                                  SCHEDULE 13D

                    Under the Securities Exchange Act of 1934
                                 AMENDMENT NO. 1



                            Interpharm Holdings, Inc.
--------------------------------------------------------------------------------
                                (Name of Company)

                          Common Stock, $0.01 par value
--------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                    460588106
--------------------------------------------------------------------------------
                      (CUSIP Number of Class of Securities)

         Joan P. Neuscheler                           Gloria M. Skigen
Tullis-Dickerson Capital Focus III, L.P.       Law Offices of Gloria M. Skigen
c/o Tullis-Dickerson Partners III, L.L.C.       Two Greenwich Plaza, 4th Fl.
     Two Greenwich Plaza, 4th Fl.                  Greenwich, CT 06830
       Greenwich, CT 06830                           (203) 861-1717
         (203) 629-8700

--------------------------------------------------------------------------------
                  (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                               November 7, 2007
--------------------------------------------------------------------------------
                          (Date of Event which Requires
                            Filing of this Schedule)

If the filing person has previously filed a statement on Schedule 13G to report
the acquisition that is the subject of this Schedule 13D, and is filing this
schedule because of Sections 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check
the following box. [ ]

NOTE: Schedules filed in paper format shall include a signed original and five
copies of the schedule, including all exhibits. See ss.240.13d-7 for other
parties to whom copies are to be sent. * The remainder of this cover page shall
be filled out for a reporting person's initial filing on this form with respect
to the subject class of securities, and for any subsequent amendment containing
information which would alter disclosures provided in a prior cover page.
The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("ACT") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, SEE the
NOTES).





                                  SCHEDULE 13D
--------------------------------------------------------------------------------
CUSIP NO.      460588106                               PAGE 2 OF 14 PAGES
--------------------------------------------------------------------------------

--------------------------------------------------------------------------------
    1     NAME OF REPORTING PERSON
          I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

          Tullis-Dickerson Capital Focus III, L.P. IRS # 06-1621801
--------------------------------------------------------------------------------
    2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP         (a) [x]
                                                                   (b) [ ]

--------------------------------------------------------------------------------
    3     SEC USE ONLY

--------------------------------------------------------------------------------
    4     SOURCE OF FUNDS*

          WC
--------------------------------------------------------------------------------
    5     CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED
          PURSUANT TO ITEMS 2(d) or 2(e)                               [ ]

--------------------------------------------------------------------------------
    6     CITIZENSHIP OR PLACE OF ORGANIZATION

          Delaware, United States of America
--------------------------------------------------------------------------------
                 7      SOLE VOTING POWER

                        0
                ----------------------------------------------------------------
NUMBER OF        8      SHARED VOTING POWER
SHARES
BENEFICIALLY            568,647 shares of Common Stock;
OWNED BY
EACH                    2,281,914 shares of Common Stock issuable upon exercise
REPORTING               of the Warrants; and
PERSON WITH
                        6,519,755 shares of Common Stock issuable upon
                        conversion of the Series B-1 Preferred Stock (1)
                ----------------------------------------------------------------
                 9      SOLE DISPOSITIVE POWER

                        0
                ----------------------------------------------------------------
                 10     SHARED DISPOSITIVE POWER

                        568,647 shares of Common Stock;

                        2,281,914 shares of Common Stock issuable upon exercise
                        of the Warrants; and

                        6,519,755 shares of Common Stock issuable upon
                        conversion of the Series B-1 Preferred Stock (1)
------------------------------------------------------------------------------
    11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH PERSON

          568,647 shares of Common Stock;

          2,281,914 shares of Common Stock issuable upon exercise of the
          Warrants; and

          6,519,755 shares of Common Stock issuable upon conversion of the
          Series B-1 Preferred Stock (1)
--------------------------------------------------------------------------------
    12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
          CERTAIN SHARES*                                                [ ]
--------------------------------------------------------------------------------
    13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

          12.5% (see Item 5)(1)
--------------------------------------------------------------------------------
    14    TYPE OF REPORTING PERSON*

          PN
--------------------------------------------------------------------------------

-----------------------

(1) Does not include  shares of Common Stock  (including  shares of Common Stock
and shares of Common Stock issuable upon the  conversion of preferred  stock and
exercise of  warrants  and  options)  held by parties to the  Irrevocable  Proxy
Agreement other than the Reporting Persons, as discussed in Item 4.





                                  SCHEDULE 13D
--------------------------------------------------------------------------------
CUSIP NO.      460588106                               PAGE 3 OF 14 PAGES
--------------------------------------------------------------------------------

--------------------------------------------------------------------------------
    1     NAME OF REPORTING PERSON
          I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

          Tullis-Dickerson Partners III, L.L.C. IRS # 06-1621800
--------------------------------------------------------------------------------
    2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP         (a) [x]
                                                                   (b) [ ]

--------------------------------------------------------------------------------
    3     SEC USE ONLY

--------------------------------------------------------------------------------
    4     SOURCE OF FUNDS*

          AF
--------------------------------------------------------------------------------
    5     CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED
          PURSUANT TO ITEMS 2(d) or 2(e)                               [ ]

--------------------------------------------------------------------------------
    6     CITIZENSHIP OR PLACE OF ORGANIZATION

          Delaware, United States of America
--------------------------------------------------------------------------------
                 7      SOLE VOTING POWER

                        0
                ----------------------------------------------------------------
NUMBER OF        8      SHARED VOTING POWER
SHARES
BENEFICIALLY            568,647 shares of Common Stock;
OWNED BY
EACH                    2,281,914 shares of Common Stock issuable upon exercise
REPORTING               of the Warrants; and
PERSON WITH
                        6,519,755 shares of Common Stock issuable upon
                        conversion of the Series B-1 Preferred Stock (1)
                ----------------------------------------------------------------
                 9      SOLE DISPOSITIVE POWER

                        0
                ----------------------------------------------------------------
                 10     SHARED DISPOSITIVE POWER

                        568,647 shares of Common Stock;

                        2,281,914 shares of Common Stock issuable upon exercise
                        of the Warrants; and

                        6,519,755 shares of Common Stock issuable upon
                        conversion of the Series B-1 Preferred Stock (1)
------------------------------------------------------------------------------
    11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH PERSON

          568,647 shares of Common Stock;

          2,281,914 shares of Common Stock issuable upon exercise of the
          Warrants; and

          6,519,755 shares of Common Stock issuable upon conversion of the
          Series B-1 Preferred Stock (1)
--------------------------------------------------------------------------------
    12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
          CERTAIN SHARES*                                                [ ]
--------------------------------------------------------------------------------
    13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

          12.5% (see Item 5)(1)
--------------------------------------------------------------------------------
    14    TYPE OF REPORTING PERSON*

          OO
--------------------------------------------------------------------------------

-----------------------

(1) Does not include  shares of Common Stock  (including  shares of Common Stock
and shares of Common Stock issuable upon the  conversion of preferred  stock and
exercise of  warrants  and  options)  held by parties to the  Irrevocable  Proxy
Agreement other than the Reporting Persons, as discussed in Item 4.





                                  SCHEDULE 13D
--------------------------------------------------------------------------------
CUSIP NO.      460588106                               PAGE 4 OF 14 PAGES
--------------------------------------------------------------------------------

--------------------------------------------------------------------------------
    1     NAME OF REPORTING PERSON
          I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

          Joan P. Neuscheler
--------------------------------------------------------------------------------
    2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP         (a) [x]
                                                                   (b) [ ]

--------------------------------------------------------------------------------
    3     SEC USE ONLY

--------------------------------------------------------------------------------
    4     SOURCE OF FUNDS*

          AF
--------------------------------------------------------------------------------
    5     CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED
          PURSUANT TO ITEMS 2(d) or 2(e)                               [ ]

--------------------------------------------------------------------------------
    6     CITIZENSHIP OR PLACE OF ORGANIZATION

          United States of America
--------------------------------------------------------------------------------
                 7      SOLE VOTING POWER

                        0
                ----------------------------------------------------------------
NUMBER OF        8      SHARED VOTING POWER
SHARES
BENEFICIALLY            568,647 shares of Common Stock;
OWNED BY
EACH                    2,281,914 shares of Common Stock issuable upon exercise
REPORTING               of the Warrants; and
PERSON WITH
                        6,519,755 shares of Common Stock issuable upon
                        conversion of the Series B-1 Preferred Stock (1)
                ----------------------------------------------------------------
                 9      SOLE DISPOSITIVE POWER

                        0
                ----------------------------------------------------------------
                 10     SHARED DISPOSITIVE POWER

                        568,647 shares of Common Stock;

                        2,281,914 shares of Common Stock issuable upon exercise
                        of the Warrants; and

                        6,519,755 shares of Common Stock issuable upon
                        conversion of the Series B-1 Preferred Stock (1)
------------------------------------------------------------------------------
    11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH PERSON

          568,647 shares of Common Stock;

          2,281,914 shares of Common Stock issuable upon exercise of the
          Warrants; and

          6,519,755 shares of Common Stock issuable upon conversion of the
          Series B-1 Preferred Stock (1)
--------------------------------------------------------------------------------
    12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
          CERTAIN SHARES*                                                [ ]
--------------------------------------------------------------------------------
    13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

          12.5% (see Item 5)(1)
--------------------------------------------------------------------------------
    14    TYPE OF REPORTING PERSON*

          IN
--------------------------------------------------------------------------------

-----------------------

(1) Does not include  shares of Common Stock  (including  shares of Common Stock
and shares of Common Stock issuable upon the  conversion of preferred  stock and
exercise of  warrants  and  options)  held by parties to the  Irrevocable  Proxy
Agreement other than the Reporting Persons, as discussed in Item 4.





                                  SCHEDULE 13D
--------------------------------------------------------------------------------
CUSIP NO.      460588106                               PAGE 5 OF 14 PAGES
--------------------------------------------------------------------------------

--------------------------------------------------------------------------------
    1     NAME OF REPORTING PERSON
          I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

          James L.L. Tullis
--------------------------------------------------------------------------------
    2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP         (a) [x]
                                                                   (b) [ ]

--------------------------------------------------------------------------------
    3     SEC USE ONLY

--------------------------------------------------------------------------------
    4     SOURCE OF FUNDS*

          AF
--------------------------------------------------------------------------------
    5     CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED
          PURSUANT TO ITEMS 2(d) or 2(e)                               [ ]

--------------------------------------------------------------------------------
    6     CITIZENSHIP OR PLACE OF ORGANIZATION

          United States of America
--------------------------------------------------------------------------------
                 7      SOLE VOTING POWER

                        0
                ----------------------------------------------------------------
NUMBER OF        8      SHARED VOTING POWER
SHARES
BENEFICIALLY            568,647 shares of Common Stock;
OWNED BY
EACH                    2,281,914 shares of Common Stock issuable upon exercise
REPORTING               of the Warrants; and
PERSON WITH
                        6,519,755 shares of Common Stock issuable upon
                        conversion of the Series B-1 Preferred Stock (1)
                ----------------------------------------------------------------
                 9      SOLE DISPOSITIVE POWER

                        0
                ----------------------------------------------------------------
                 10     SHARED DISPOSITIVE POWER

                        568,647 shares of Common Stock;

                        2,281,914 shares of Common Stock issuable upon exercise
                        of the Warrants; and

                        6,519,755 shares of Common Stock issuable upon
                        conversion of the Series B-1 Preferred Stock (1)
------------------------------------------------------------------------------
    11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH PERSON

          568,647 shares of Common Stock;

          2,281,914 shares of Common Stock issuable upon exercise of the
          Warrants; and

          6,519,755 shares of Common Stock issuable upon conversion of the
          Series B-1 Preferred Stock (1)
--------------------------------------------------------------------------------
    12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
          CERTAIN SHARES*                                                [ ]
--------------------------------------------------------------------------------
    13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

          12.5% (see Item 5)(1)
--------------------------------------------------------------------------------
    14    TYPE OF REPORTING PERSON*

          IN
--------------------------------------------------------------------------------

-----------------------

(1) Does not include  shares of Common Stock  (including  shares of Common Stock
and shares of Common Stock issuable upon the  conversion of preferred  stock and
exercise of  warrants  and  options)  held by parties to the  Irrevocable  Proxy
Agreement other than the Reporting Persons, as discussed in Item 4.





                                  SCHEDULE 13D
--------------------------------------------------------------------------------
CUSIP NO.      460588106                               PAGE 6 OF 14 PAGES
--------------------------------------------------------------------------------

--------------------------------------------------------------------------------
    1     NAME OF REPORTING PERSON
          I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

          Thomas P. Dickerson
--------------------------------------------------------------------------------
    2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP         (a) [x]
                                                                   (b) [ ]

--------------------------------------------------------------------------------
    3     SEC USE ONLY

--------------------------------------------------------------------------------
    4     SOURCE OF FUNDS*

          AF
--------------------------------------------------------------------------------
    5     CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED
          PURSUANT TO ITEMS 2(d) or 2(e)                               [ ]

--------------------------------------------------------------------------------
    6     CITIZENSHIP OR PLACE OF ORGANIZATION

          United States of America
--------------------------------------------------------------------------------
                 7      SOLE VOTING POWER

                        0
                ----------------------------------------------------------------
NUMBER OF        8      SHARED VOTING POWER
SHARES
BENEFICIALLY            568,647 shares of Common Stock;
OWNED BY
EACH                    2,281,914 shares of Common Stock issuable upon exercise
REPORTING               of the Warrants; and
PERSON WITH
                        6,519,755 shares of Common Stock issuable upon
                        conversion of the Series B-1 Preferred Stock (1)
                ----------------------------------------------------------------
                 9      SOLE DISPOSITIVE POWER

                        0
                ----------------------------------------------------------------
                 10     SHARED DISPOSITIVE POWER

                        568,647 shares of Common Stock;

                        2,281,914 shares of Common Stock issuable upon exercise
                        of the Warrants; and

                        6,519,755 shares of Common Stock issuable upon
                        conversion of the Series B-1 Preferred Stock (1)
------------------------------------------------------------------------------
    11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH PERSON

          568,647 shares of Common Stock;

          2,281,914 shares of Common Stock issuable upon exercise of the
          Warrants; and

          6,519,755 shares of Common Stock issuable upon conversion of the
          Series B-1 Preferred Stock (1)
--------------------------------------------------------------------------------
    12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
          CERTAIN SHARES*                                                [ ]
--------------------------------------------------------------------------------
    13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

          12.5% (see Item 5)(1)
--------------------------------------------------------------------------------
    14    TYPE OF REPORTING PERSON*

          IN
--------------------------------------------------------------------------------

-----------------------

(1) Does not include  shares of Common Stock  (including  shares of Common Stock
and shares of Common Stock issuable upon the  conversion of preferred  stock and
exercise of  warrants  and  options)  held by parties to the  Irrevocable  Proxy
Agreement other than the Reporting Persons, as discussed in Item 4.





                                  SCHEDULE 13D
--------------------------------------------------------------------------------
CUSIP NO.      460588106                               PAGE 7 OF 14 PAGES
--------------------------------------------------------------------------------

--------------------------------------------------------------------------------
    1     NAME OF REPORTING PERSON
          I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

          Lyle A. Hohnke
--------------------------------------------------------------------------------
    2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP         (a) [x]
                                                                   (b) [ ]

--------------------------------------------------------------------------------
    3     SEC USE ONLY

--------------------------------------------------------------------------------
    4     SOURCE OF FUNDS*

          AF
--------------------------------------------------------------------------------
    5     CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED
          PURSUANT TO ITEMS 2(d) or 2(e)                               [ ]

--------------------------------------------------------------------------------
    6     CITIZENSHIP OR PLACE OF ORGANIZATION

          United States of America
--------------------------------------------------------------------------------
                 7      SOLE VOTING POWER

                        0
                ----------------------------------------------------------------
NUMBER OF        8      SHARED VOTING POWER
SHARES
BENEFICIALLY            568,647 shares of Common Stock;
OWNED BY
EACH                    2,281,914 shares of Common Stock issuable upon exercise
REPORTING               of the Warrants; and
PERSON WITH
                        6,519,755 shares of Common Stock issuable upon
                        conversion of the Series B-1 Preferred Stock (1)
                ----------------------------------------------------------------
                 9      SOLE DISPOSITIVE POWER

                        0
                ----------------------------------------------------------------
                 10     SHARED DISPOSITIVE POWER

                        568,647 shares of Common Stock;

                        2,281,914 shares of Common Stock issuable upon exercise
                        of the Warrants; and

                        6,519,755 shares of Common Stock issuable upon
                        conversion of the Series B-1 Preferred Stock (1)
------------------------------------------------------------------------------
    11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH PERSON

          568,647 shares of Common Stock;

          2,281,914 shares of Common Stock issuable upon exercise of the
          Warrants; and

          6,519,755 shares of Common Stock issuable upon conversion of the
          Series B-1 Preferred Stock (1)
--------------------------------------------------------------------------------
    12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
          CERTAIN SHARES*                                                [ ]
--------------------------------------------------------------------------------
    13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

          12.5% (see Item 5)(1)
--------------------------------------------------------------------------------
    14    TYPE OF REPORTING PERSON*

          IN
--------------------------------------------------------------------------------

-----------------------

(1) Does not include  shares of Common Stock  (including  shares of Common Stock
and shares of Common Stock issuable upon the  conversion of preferred  stock and
exercise of  warrants  and  options)  held by parties to the  Irrevocable  Proxy
Agreement other than the Reporting Persons, as discussed in Item 4.





                                  SCHEDULE 13D
--------------------------------------------------------------------------------
CUSIP NO.      460588106                               PAGE 8 OF 14 PAGES
--------------------------------------------------------------------------------

--------------------------------------------------------------------------------
    1     NAME OF REPORTING PERSON
          I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

          Timothy M. Buono
--------------------------------------------------------------------------------
    2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP         (a) [x]
                                                                   (b) [ ]

--------------------------------------------------------------------------------
    3     SEC USE ONLY

--------------------------------------------------------------------------------
    4     SOURCE OF FUNDS*

          AF
--------------------------------------------------------------------------------
    5     CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED
          PURSUANT TO ITEMS 2(d) or 2(e)                               [ ]

--------------------------------------------------------------------------------
    6     CITIZENSHIP OR PLACE OF ORGANIZATION

          United States of America
--------------------------------------------------------------------------------
                 7      SOLE VOTING POWER

                        0
                ----------------------------------------------------------------
NUMBER OF        8      SHARED VOTING POWER
SHARES
BENEFICIALLY            568,647 shares of Common Stock;
OWNED BY
EACH                    2,281,914 shares of Common Stock issuable upon exercise
REPORTING               of the Warrants; and
PERSON WITH
                        6,519,755 shares of Common Stock issuable upon
                        conversion of the Series B-1 Preferred Stock (1)
                ----------------------------------------------------------------
                 9      SOLE DISPOSITIVE POWER

                        0
                ----------------------------------------------------------------
                 10     SHARED DISPOSITIVE POWER

                        568,647 shares of Common Stock;

                        2,281,914 shares of Common Stock issuable upon exercise
                        of the Warrants; and

                        6,519,755 shares of Common Stock issuable upon
                        conversion of the Series B-1 Preferred Stock (1)
------------------------------------------------------------------------------
    11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH PERSON

          568,647 shares of Common Stock;

          2,281,914 shares of Common Stock issuable upon exercise of the
          Warrants; and

          6,519,755 shares of Common Stock issuable upon conversion of the
          Series B-1 Preferred Stock (1)
--------------------------------------------------------------------------------
    12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
          CERTAIN SHARES*                                                [ ]
--------------------------------------------------------------------------------
    13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

          12.5% (see Item 5)(1)
--------------------------------------------------------------------------------
    14    TYPE OF REPORTING PERSON*

          IN
--------------------------------------------------------------------------------

-----------------------

(1) Does not include  shares of Common Stock  (including  shares of Common Stock
and shares of Common Stock issuable upon the  conversion of preferred  stock and
exercise of  warrants  and  options)  held by parties to the  Irrevocable  Proxy
Agreement other than the Reporting Persons, as discussed in Item 4.





                                  SCHEDULE 13D

The Schedule 13D filed on June 6, 2006 (the "SCHEDULE 13D") by  Tullis-Dickerson
Capital Focus III, L.P.  ("CAPITAL FOCUS III"),  Tullis-Dickerson  Partners III,
L.L.C. ("PARTNERS III"), Joan P. Neuscheler  ("NEUSCHELER"),  James L. L. Tullis
("TULLIS"),  Thomas P. Dickerson  ("DICKERSON"),  Lyle A. Hohnke  ("HOHNKE") and
Timothy M. Buono  ("BUONO" and together  with Capital  Focus III,  Partners III,
Neuscheler,  Tullis,  Dickerson and Hohnke, the "REPORTING PERSONS") relating to
the common stock, par value $0.01 per share (the "COMMON STOCK"),  of Interpharm
Holdings,  Inc. (the "ISSUER"), is hereby amended as set forth by this Amendment
No. 1.


ITEM 4.  PURPOSE OF TRANSACTION.

Item 4 of the Schedule 13D is hereby amended to add the following:

On November  7, 2007 the Issuer,  Capital  Focus III,  Aisling  Capital II, L.P.
("AISLING"),  Rametra Holdings I, LLC ("RAMETRA  HOLDINGS"),  P&K Holdings,  LLC
("P&K HOLDINGS"),  Rajs Holdings I, LLC ("RAJS  HOLDINGS"),  Perry Sutaria,  Raj
Sutaria and  Cameron  Reid  entered  into a Consent  and Waiver  Agreement  (the
"CONSENT AND WAIVER  AGREEMENT")  in which  Capital  Focus III waived its rights
arising  out of the  Issuer's  default  under  the  Series  B-1  Certificate  of
Designations  (as defined in the  Schedule  13D) and  Aisling  waived its rights
arising out of the  Issuer's  default  under the  Certificate  of  Designations,
Preferences and Rights of Series C-1  Convertible  Preferred Stock of the Issuer
(the  "SERIES C-1 COD").  As a condition  for  Capital  Focus III and  Aisling's
waiver  of  their  respective  rights,  Rametra  Holdings,  P&K  Holdings,  Rajs
Holdings,  Raj Sutaria and Perry  Sutaria  entered  into the  Irrevocable  Proxy
Agreement (as defined below). Pursuant to the Consent and Waiver Agreement,  the
Issuer  will,  subject to  receiving  the  approval of its  stockholders  (which
approval,  pursuant to the terms of the Consent and Waiver Agreement,  cannot be
obtained  earlier  than  January 18,  2008) for the  issuance of the  securities
contemplated  by the Consent and Waiver  Agreement in accordance with applicable
law  and  the  rules  and  regulations  of  the  American  Stock  Exchange  (the
"STOCKHOLDER APPROVAL"), (i) exchange the Series B-1 Preferred Stock (as defined
in the Schedule  13D) held by Capital  Focus III,  and the  Issuer's  Series C-1
Preferred  Stock,  par value $0.01 (the "SERIES C-1 PREFERRED  STOCK"),  held by
Aisling, for new shares of the Issuer's Series D-1 Convertible  Preferred Stock,
par value $0.01 (the "SERIES D-1  PREFERRED  STOCK")  which Series D-1 Preferred
Stock shall be  convertible  into the Common Stock  pursuant to the terms of the
Certificate of  Designations,  Preferences  and Rights of Series D-1 Convertible
Preferred Stock of the Issuer (the "SERIES D-1 COD"); and (ii) Capital Focus III
will  exchange the Warrant (as defined in the Schedule 13D) for a new warrant to
purchase  2,281,914  shares of Common  Stock at an  exercise  price of $0.95 per
share (the "NEW  TULLIS  WARRANT")  and  Aisling  will  exchange  those  certain
warrants  to  purchase  2,281,914  shares  of common  stock of the  Issuer at an
exercise  price of $1.60 per share  previously  issued to Aisling (the  "AISLING
WARRANTS") for a new warrant to purchase  2,281,914 shares of Common Stock at an
exercise price of $0.95 per share (the "NEW AISLING WARRANT",  together with the
New Tullis  Warrant,  the "NEW WARRANTS" and the New Warrants  together with the
Series D-1 Preferred Stock, the "NEW SECURITIES"). Capital Focus III and Aisling
will receive  1.04125  shares of Series D-1 Preferred  Stock for each  exchanged
share of their  respective  Series B-1 Preferred  Stock and Series C-1 Preferred
Stock.  The New  Securities  will  provide for an  adjustment  to the Series D-1
Preferred  Stock  conversion  price  and  the New  Warrant  exercise  price,  as
applicable, whereby, in





the event that the Issuer  issues or is deemed to have issued  Common Stock at a
price per share lower than the new then applicable preferred conversion price or
warrant exercise price, as applicable (the "NEW SECURITIES ISSUANCE PRICE"), the
then  applicable  preferred  conversion  price or  warrant  exercise  price,  as
applicable,  will be reduced to 90% of the New Securities  Issuance  Price.

The Series D-1 COD will have similar provisions to the Series B-1 Certificate of
Designations  including  provisions  providing  that so long as Tullis  holds at
least 25% of the  shares of the  Series  D-1  Preferred  Stock  issued to it, in
addition  to any other  rights  provided by law,  without  first  obtaining  the
affirmative  vote at a meeting  duly  called  for such  purpose  or the  written
consent of the holders of a majority of the outstanding shares of the Series D-1
Preferred  Stock,  voting together as a single class,  the Issuer may not, among
other things:

               issue any  shares of Common  Stock,  stock  appreciation  rights,
               stock  options or other equity  securities to  independent  third
               parties in excess of 2% of the fully diluted  number of shares of
               Common Stock on the initial closing date;

               pay dividends or make any other distribution on the capital stock
               of  the  Issuer  other  than  (i)  dividends  on the  Series  D-1
               Preferred Stock or (ii) the stated dividends on the shares of the
               Issuer's Series A-1 Convertible Preferred Stock;

               issue any  Common  Stock or any  securities  convertible  into or
               exchangeable  for  Common  Stock at a price  per  share of Common
               Stock  less than the  purchase  price per share of the Series D-1
               Preferred Stock; and

               issue any indebtedness  that creates an obligation for the Issuer
               to repay in the aggregate  more than $50 million in principal and
               interest.

The foregoing  description of the Consent and Waiver  Agreement,  the Series D-1
COD and the New  Warrants is a summary  only and is qualified in its entirety by
reference  to the Consent and Waiver  Agreement,  Series D-1 COD and Form of New
Warrant  which  are  filed as  Exhibits  6, 7 and 8  hereto,  respectively,  and
incorporated herein by reference.

On  November  7,  2007,  Rametra  Holdings,   P&K  Holdings  and  Rajs  Holdings
(collectively,  the  "LLCS")  (for  each of  which  Perry  Sutaria  is the  sole
manager),  Raj Sutaria  and Perry  Sutaria  (the  "SUTARIAS"),  entered  into an
Irrevocable  Proxy  Agreement,  of which Capital Focus III and Aisling are third
party beneficiaries (the "IRREVOCABLE PROXY AGREEMENT"), pursuant to which Perry
Sutaria,   Aisling  and  Capital  Focus  III  shall  appoint  a  committee  (the
"COMMITTEE")  consisting of three  members (the  "COMMITTEE  MEMBERS").  Each of
Capital  Focus III,  Aisling and Perry  Sutaria are  permitted to designate  one
Committee  Member to the Committee.  The  Committee,  acting by a majority vote,
shall  function as the proxy with  respect to all of the Shares of Common  Stock
held by Sutaria  and the LLCs (the  "PROXY  SHARES")  solely for the  purpose of
electing or removing  members of the Board of Directors of the Issuer and voting
on amendments,  additions,  deletions or  modifications  to the Issuer's by-laws
(the "COMMITTEE MATTERS"). As a result of the majority voting requirement of the
Committee,  no  individual  Committee  Member  can direct the vote of the Shares
subject to the Irrevocable Proxy Agreement or control such vote. The Irrevocable





Proxy Agreement can be terminated in certain  circumstances  as specified in the
agreement.  The foregoing  description of the  Irrevocable  Proxy Agreement is a
summary only and is  qualified  in its entirety by reference to the  Irrevocable
Proxy Agreement,  which is filed as Exhibit 9 hereto and incorporated  herein by
reference.

By virtue of the  Irrevocable  Proxy  Agreement,  the  Reporting  Persons may be
deemed to have formed a "group,"  within the meaning of Section  13(d)(3) of the
Securities Act of 1934, with the parties to the Irrevocable  Proxy Agreement and
may be deemed to have voting  control over 76.4% of the shares of Common  Stock.
The  percentages  used  in  this  Amendment  No.  1 are  calculated  based  upon
66,190,000  shares of Common Stock  reported to be  outstanding by the Issuer in
its Annual  Report on Form 10-K for the fiscal year ended June 30,  2007,  filed
with the Securities and Exchange Commission on November 15, 2007. However,  each
of the Reporting Persons expressly disaffirm the existence of a group with other
parties to the Irrevocable  Proxy Agreement and expressly  disclaims  beneficial
ownership of the shares of Common Stock  beneficially  owned by the Sutarias and
the  LLCs.  Neither  the  Reporting  Persons  nor  any  of  the  parties  to the
Irrevocable  Proxy Agreement,  individually  have the power to control more than
one Committee Member and therefore do not control the vote of the Committee with
regard to the Committee Matters.

Upon  information  and  belief,  the  other  parties  to the  Irrevocable  Proxy
Agreement will be filing their own Schedule 13D separately,  with respect to the
Issuer.  As of the date of this  Amendment No. 1, upon  information  and belief,
Aisling may be deemed to  beneficially  own 9.99% of the Common Stock  including
(i) shares  issuable  upon  exercise  of  warrants;  (ii) shares  issuable  upon
conversion of preferred  stock;  and (iii) shares of Common Stock (the preferred
stock held by Aisling is subject to a 9.99%  blocker  pursuant to which a holder
of the Series C-1 Preferred Stock does not have the right to vote the Series C-1
Preferred  Stock or convert the Series C-1 Preferred  Stock into Common Stock to
the extent that such  conversion  or voting  rights would  result in  beneficial
ownership  by such  holder of more than  9.99% of the number of shares of Common
Stock  outstanding  immediately after giving effect to such conversion or voting
rights.  As of the date of this  Amendment No. 1, upon  information  and belief,
Rametra  Holdings,  P&K  Holdings,  Rajs  Holdings and Perry  Sutaria,  together
referred to as the Sutaria Entities,  may be deemed to beneficially own 53.9% of
the Common Stock.

On November 14, 2007 the Issuer and Tullis,  Aisling,  the Sutaria Family Realty
LLC and Cameron Reid (collectively,  the "PURCHASERS") entered into a Securities
Purchase  Agreement  (the "NOTE  PURCHASE  AGREEMENT")  pursuant to which Issuer
agreed to sell and the  Purchasers  agreed to purchase the Issuer's  Secured 12%
Notes due 2009 (the "NON-CONVERTIBLE  NOTES"). Pursuant to the terms of the Note
Purchase  Agreement,  the Issuer will,  subject to receiving the approval of its
stockholders  (which  approval,  pursuant  to the  terms  of the  Note  Purchase
Agreement, cannot be obtained earlier than January 18, 2008) for the issuance of
the Note Securities (as defined below) in accordance with applicable law and the
rules and  regulations  of the American  Stock  Exchange (the "NOTE  STOCKHOLDER
APPROVAL"), exchange the Non-Convertible Notes of the Purchasers for (i) Secured
Convertible 12% Notes due 2009 (the "CONVERTIBLE  NOTES"),  which notes shall be
convertible into shares of Common Stock at a conversion price of $0.95 per share
and (ii)  warrants  (the "NOTE  WARRANTS") to purchase an aggregate of 1,842,103
shares of Common Stock at an exercise  price of $0.95 per share.  Under the Note
Purchase Agreement,  the Purchasers were granted the right to include the shares
of Common Stock they would receive upon the conversion of the Convertible  Notes
or the exercise





of the Note Warrants in any securities act  registration  statement filed by the
Issuer,  subject to certain  exceptions.  The foregoing  description of the Note
Purchase  Agreement,  the  Non-Convertible  Notes, the Convertible Notes and the
Note Warrants is a summary only and is qualified in its entirety by reference to
the Note Purchase Agreement, the Non-Convertible Note, the Convertible Notes and
the Note  Warrants  which  are  filed as  Exhibits  10,  11,  12 and 13  hereto,
respectively, and incorporated herein by reference.

ITEM 5.  INTEREST IN SECURITIES OF THE COMPANY.

Item 5 (a) and (b) of the Schedule 13D are hereby amended and restated as
follows:

      (a) As of the date of this  Amendment No. 1, the Reporting  Persons may be
deemed to  beneficially  own  9,370,316  shares of Common  Stock,  including (i)
2,281,914  shares issuable upon exercise of the Warrants;  (ii) 6,519,755 shares
issuable upon  conversion of the Series B-1 Preferred  Stock;  and (iii) 568,647
shares of Common  Stock  currently  owned by Capital  Focus  III.  The shares of
Common  Stock  that the  Reporting  Persons  may be deemed to  beneficially  own
represent  12.5% of the  Common  Stock.  In the event the  Issuer  obtains  the
Stockholder  Approval and the Note  Stockholder  Approval and, as a result,  the
Securities  (as defined in the 13D) are exchanged for the New Securities and the
Non-Convertible  Notes  are  exchanged  for the  Convertible  Notes and the Note
Warrants (the "EXCHANGE EVENT"),  each of the Reporting Persons may be deemed to
beneficially  own  14,561,088  shares of Common Stock  including  (i)  2,281,914
shares of Common  Stock  issuable  to  Capital  Focus III upon  exercise  of the
Amended and Restated  Warrants;  (ii) 10,526,316 shares of Common Stock issuable
to Capital Focus III upon  conversion of the Series D-1 Preferred  Stock;  (iii)
877,194 shares of Common Stock issuable to Capital Focus III upon  conversion of
the Convertible  Notes;  (iv) 307,017 shares of Common Stock issuable to Capital
Focus III upon conversion of the Note Warrants; and (v) 568,647 shares of Common
Stock  currently  owned by Capital  Focus III. The  14,561,088  shares of Common
Stock  that the  Reporting  Persons  may be  deemed to  beneficially  own if the
Exchange Event occurs represent 18.2% of the Common Stock.  Partners III is the
sole general partner of Capital Focus III. Neuscheler, Tullis, Dickerson, Hohnke
and Buono share voting and/or  dispositive power over all shares of Common Stock
held by Capital Focus III. The Reporting Persons disclaim  beneficial  ownership
of the shares of Common Stock  beneficially  owned except to the extent of their
pecuniary  interests therein.  As discussed in Item 4, the Reporting Persons may
be deemed to be a group within the meaning of Section 13(d)(3) of the Securities
and Exchange Act of 1934,  however,  the Reporting Persons disclaim the creation
of a group with the parties to the Irrevocable Proxy Agreement.

     (b)  Partners  III is the  sole  general  partner  of  Capital  Focus  III.
Neuscheler,  Tullis, Dickerson, Hohnke and Buono share voting and/or dispositive
power over all shares.  These individuals  disclaim beneficial  ownership of the
shares of Common Stock  beneficially  owned by the above entities  except to the
extent of their pecuniary  interests  therein.  The Reporting  Persons  disclaim
their  ability  to direct  the  voting of Issuer  shares,  other than those held
directly  by  the  Reporting  Persons,  as a  result  of the  Irrevocable  Proxy
Agreement as discussed in Item 4.





     (c) During the last  sixty  days there were no  transactions  in the Common
Stock  effected.  The  Reporting  Persons  disclaim  their ability to direct the
voting of the Common  Stock as a result of the  Irrevocable  Proxy  Agreement as
discussed in Item 4.

     (d) The partners or members of Capital  Focus III and Partners III have the
right to  participate  indirectly in the receipt of dividends  from, or proceeds
from the sale of, the shares of Common Stock in accordance with their respective
ownership interests in their respective entities.

     (e) Not applicable.

ITEM 6. CONTRACTS, ARRANGEMENTS, UNDERSTANDINGS OR RELATIONSHIPS WITH RESPECT TO
SECURITIES OF THE ISSUER.

     As  described  in Item 4 above,  on November 7, 2007,  the Issuer,  Capital
Focus III, Aisling Rametra Holdings,  P&K Holdings,  Rajs Holdings, Raj Sutaria,
Perry  Sutaria and Cameron Reid entered into a Consent and Waiver  Agreement,  a
copy of which is attached as Exhibit 6 hereto.

     As  described  in Item 4 above,  if the  Stockholder  Approval is obtained,
Capital Focus III will receive  Series D-1 Preferred  Stock,  the  designations,
preferences  and  relative  participating,  optional  or other  rights,  and the
qualifications,  limitations  or  restrictions  thereof  are  set  forth  in the
Certificate of  Designations,  Preferences  and Rights of Series D-1 Convertible
Preferred Stock, a copy of which is attached as Exhibit 7 hereto.

     As  described  in Item 4 above,  if the  Stockholder  Approval is obtained,
Capital Focus III will exchange its Warrant for a New Warrant, the form of which
is attached as Exhibit 8 hereto.

     As described in Item 4 above,  on November 7, 2007, the  Irrevocable  Proxy
was entered into by the LLCs, Raj Sutaria and Perry  Sutaria,  pursuant to which
Perry  Sutaria,  Aisling and Capital  Focus III shall  appoint the  Committee to
direct the vote the Proxy Shares with respect to  Committee  Matters,  a copy of
which is attached as Exhibit 9 hereto.

     As described in Item 4 above, on November 14, 2007, the Issuer,  Tullis and
the other Purchasers entered into the Note Purchase  Agreement,  a copy of which
is attached as Exhibit 10 hereto.

     As  described  in Item 4 above,  pursuant to the Note  Purchase  Agreement,
Capital Focus III purchased from the Issuer a Non-Convertible  Note, the form of
which is attached as Exhibit 11 hereto.

     As described in Item 4 above, if the Note Stockholder Approval is obtained,
Capital Focus III will exchange its Non-Convertible  Note for a Convertible Note
and Note  Warrant,  the forms of which is attached are Exhibit 12 and Exhibit 13
hereto, respectively.





     Except as otherwise set forth herein, the Reporting Persons do not have any
contract,  arrangement,  understanding  or  relationship  with any  person  with
respect to the securities of the Issuer.


ITEM 7.  MATERIAL TO BE FILED AS EXHIBITS.

Item 7 of the Schedule 13D is hereby amended to add of the following:

6. Consent and Waiver Agreement, dated November 7, 2007, by and among Interpharm
Holdings, Inc,  Tullis-Dickerson Capital Focus III, L.P, Aisling Capital II, LP,
Perry Sutaria Rametra Holdings I, LLC, P&K Holdings,  LLC, Rajs Holdings I, LLC,
Raj Sutaria and Cameron Reid  (incorporated  by reference herein to the Issuer's
10-K filed on November 15, 2007).

7. Form of Certificate  of  Designations,  Preferences  and Rights of Series D-1
Convertible  Preferred Stock  (incorporated  by reference herein to the Issuer's
10-K filed on November 15, 2007).

8. Form of New Warrant to  Purchase  Common  Stock  (incorporated  by  reference
herein to the Issuer's 10-K filed on November 15, 2007).

9.  Irrevocable  Proxy  Agreement,  dated  November 7, 2007,  by and among Perry
Sutaria,  Raj  Sutaria,  Rametra  Holdings I, LLC,  P&K  Holdings,  LLC and Rajs
Holdings I, LLC.

10.  Securities  Purchase  Agreement,  dated  November  14,  2007  by and  among
Interpharm  Holdings,  Inc,  Tullis-Dickerson  Capital Focus III,  L.P,  Aisling
Capital II, LP, the Sutaria Family Realty LLC and Cameron Reid  (incorporated by
reference herein to the Issuer's 10-K filed on November 15, 2007).

11.  Form of  Non-Convertible  Note  (incorporated  by  reference  herein to the
Issuer's 10-K filed on November 15, 2007).

12. Form of Convertible  Note  (incorporated by reference herein to the Issuer's
10-K filed on November 15, 2007).

13. Form of Note Warrant  (incorporated by reference herein to the Issuer's 10-K
filed on November 15, 2007).





                                   SIGNATURES

         After reasonable inquiry and to the best of his knowledge and belief,
each of the undersigned certifies that the information set forth in this
statement is true, complete and correct.


November 16, 2007                TULLIS-DICKERSON CAPITAL  FOCUS III, L.P.

                                 BY:      TULLIS-DICKERSON PARTNERS III, L.L.C.,
                                 ITS:     GENERAL PARTNER

                                 By:      /s/ Joan P. Neuscheler
                                          -----------------------------
                                          JOAN P. NEUSCHELER
                                          Principal

November 16, 2007                         TULLIS-DICKERSON PARTNERS III, L.L.C.

                                 By:      /S/ JOAN P. NEUSCHELER
                                          JOAN P. NEUSCHELER
                                          Principal


November 16, 2007                         /s/ Joan P. Neuscheler
                                          -----------------------------
                                          JOAN P. NEUSCHELER

November 16, 2007                         /s/ James L.L. Tullis
                                          -----------------------------
                                          JAMES L.L. TULLIS

November 16, 2007                         /s/ Thomas P. Dickerson
                                          -----------------------------
                                          THOMAS P. DICKERSON

November 16, 2007                         /s/ Lyle A. Hohnke
                                          -----------------------------
                                          LYLE A. HOHNKE

November 16, 2007                         /s/ Timothy M. Buono
                                          -----------------------------
                                          TIMOTHY M. BUONO





                                  EXHIBIT INDEX

The Exhibit Index of the Schedule 13D is hereby amended to add the following:

6. Consent and Waiver Agreement, dated November 7, 2007, by and among Interpharm
Holdings, Inc,  Tullis-Dickerson Capital Focus III, L.P, Aisling Capital II, LP,
Perry Sutaria Rametra Holdings I, LLC, P&K Holdings,  LLC, Rajs Holdings I, LLC,
Raj Sutaria and Cameron Reid  (incorporated  by reference herein to the Issuer's
10-K filed November on 15, 2007).

7. Form of Certificate  of  Designations,  Preferences  and Rights of Series D-1
Convertible  Preferred Stock  (incorporated  by reference herein to the Issuer's
10-K filed November on 15, 2007).

8. Form of New Warrant to  Purchase  Common  Stock  (incorporated  by  reference
herein to the Issuer's 10-K filed November on 15, 2007).

9.  Irrevocable  Proxy  Agreement,  dated  November 7, 2007,  by and among Perry
Sutaria,  Raj  Sutaria,  Rametra  Holdings I, LLC,  P&K  Holdings,  LLC and Rajs
Holdings I, LLC.

10.  Securities  Purchase  Agreement,  dated  November  14,  2007  by and  among
Interpharm  Holdings,  Inc,  Tullis-Dickerson  Capital Focus III,  L.P,  Aisling
Capital II, LP, the Sutaria Family Realty LLC and Cameron Reid  (incorporated by
reference herein to the Issuer's 10-K filed on November 15, 2007).

11.  Form of  Non-Convertible  Note  (incorporated  by  reference  herein to the
Issuer's 10-K filed November on 15, 2007).

12. Form of Convertible  Note  (incorporated by reference herein to the Issuer's
10-K filed November on 15, 2007).

13. Form of Note Warrant  (incorporated by reference herein to the Issuer's 10-K
filed on November 15, 2007).