UNITED STATES

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934
                                (Amendment No. )*

                               DURECT CORPORATION
                               ------------------
                                (Name of Issuer)

                  Common Stock, $.0001 par value per share
                  --------------------------------------------
                         (Title of Class of Securities)

                                    266605104
                                    ---------
                                 (CUSIP Number)

                                 August 2, 2005
                                 ---------------
             (Date of Event which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

            [ ] Rule 13d-1(b)
            [X] Rule 13d-1(c)
            [ ] Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the 
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).

                          Continued on following pages
                               Page 1 of 10 Pages
                              Exhibit Index: Page 9



                                  SCHEDULE 13G

CUSIP No. 266605104                                         Page 2 of 10 Pages

1        Names of Reporting Persons
         I.R.S. Identification Nos. of above persons (entities only)

                  SAGAMORE HILL CAPITAL MANAGEMENT L.P.

2        Check the Appropriate Box If a Member of a Group (See Instructions)

                                            a.  [ ]
                                            b.  [X]

3        SEC Use Only

4        Citizenship or Place of Organization

                  DELAWARE

                            5             Sole Voting Power
Number of                                         3,045,714
  Shares
Beneficially                6             Shared Voting Power
  Owned By                                        0
    Each
Reporting                   7             Sole Dispositive Power
    Person                                        3,045,714
    With
                            8             Shared Dispositive Power
                                                  0

9        Aggregate Amount Beneficially Owned by Each Reporting Person

                                 3,045,714

10       Check Box If the Aggregate Amount in Row (9) Excludes Certain
         Shares (See Instructions)

                                 [ ]

11       Percent of Class Represented By Amount in Row (9)

                                 5.5%

12       Type of Reporting Person (See Instructions)

                                 PN

                                  SCHEDULE 13G

CUSIP No. 266605104                                         Page 3 of 10 Pages

1        Names of Reporting Persons
         I.R.S. Identification Nos. of above persons (entities only)

                  SAGAMORE HILL MANAGERS LLC

2        Check the Appropriate Box If a Member of a Group (See Instructions)

                                            a.  [ ]
                                            b.  [X]

3        SEC Use Only

4        Citizenship or Place of Organization

                  DELAWARE

                            5             Sole Voting Power
Number of                                         3,045,714
  Shares
Beneficially                6             Shared Voting Power
  Owned By                                        0
    Each
Reporting                   7             Sole Dispositive Power
    Person                                        3,045,714
    With
                            8             Shared Dispositive Power
                                                  0

9        Aggregate Amount Beneficially Owned by Each Reporting Person

                                 3,045,714

10       Check Box If the Aggregate Amount in Row (9) Excludes Certain
         Shares (See Instructions)

                                 [ ]

11       Percent of Class Represented By Amount in Row (9)

                                 5.5%

12       Type of Reporting Person (See Instructions)

                                    OO

                                  SCHEDULE 13G

CUSIP No. 266605104                                         Page 4 of 10 Pages

1        Names of Reporting Persons
         I.R.S. Identification Nos. of above persons (entities only)

                  STEVEN H. BLOOM

2        Check the Appropriate Box If a Member of a Group (See Instructions)

                                            a.  [ ]
                                            b.  [X]

3        SEC Use Only

4        Citizenship or Place of Organization

                  UNITED STATES

                            5             Sole Voting Power
Number of                                         3,045,714
  Shares
Beneficially                6             Shared Voting Power
  Owned By                                        0
    Each
Reporting                   7             Sole Dispositive Power
    Person                                        3,045,714
    With
                            8             Shared Dispositive Power
                                                  0

9        Aggregate Amount Beneficially Owned by Each Reporting Person

                                 3,045,714

10       Check Box If the Aggregate Amount in Row (9) Excludes Certain
         Shares (See Instructions)

                                 [ ]

11       Percent of Class Represented By Amount in Row (9)

                                 5.5%

12       Type of Reporting Person (See Instructions)

                                 IN; HC

                                  SCHEDULE 13G

CUSIP No. 266605104                                         Page 5 of 10 Pages

Item 1(a)         Name of Issuer:

                  Durect Corporation (the "Issuer")

Item 1(b)         Address of the Issuer's Principal Executive Offices:

                  10240 Bubb Road, Cupertino, California 95014

Item 2(a)         Name of Person Filing:

                  The Statement is filed on behalf of each of the following 
persons (collectively, the "Reporting Persons"):

                  i.    Sagamore Hill Capital Management L.P. ("Sagamore Hill 
                        Capital Management");

                  ii.   Sagamore Hill Managers LLC ("Sagamore Hill Managers");
                        and

                  iii.  Steven H. Bloom ("Mr. Steven Bloom").

                  This Statement relates to securities held for the account of 
the Sagamore Hill Hub Fund Ltd., a Cayman Islands corporation (the "Hub Fund"). 
Pursuant to a portfolio management agreement, Sagamore Hill Capital Management
serves as investment manager of the Hub Fund. In such capacity, Sagamore Hill 
Capital Management may be deemed to be the beneficial owner of securities held 
for the account of the Hub Fund. The general partner of Sagamore Hill Capital
Management is Sagamore Hill Managers. In such capacity, Sagamore Hill Managers 
may be deemed to be the beneficial owner of securities held for the account of 
the Hub Fund. Mr. Steven Bloom is the sole member of Sagamore Hill Managers. In 
such capacity, Mr. Steven Bloom may be deemed to be the beneficial owner of 
securities held for the account of the Hub Fund.

Item 2(b)         Address of Principal Business Office or, if None, Residence:

                  The address of the principal business office of each of the 
Reporting Persons is 10 Glenville Street, 3rd Floor, Greenwich, CT 06831.

Item 2(c)         Citizenship:

                  1)  Sagamore Hill Capital Management is a Delaware limited 
                      partnership;

                  2)  Sagamore Hill Managers is a Delaware limited liability 
                      company; and

                  3)  Mr. Steven Bloom is a citizen of the United States.

Item 2(d)         Title of Class of Securities:

                  Common Stock, $.0001 par value per share (the "Shares").

Item 2(e)         CUSIP Number:

                  266605104

                                  SCHEDULE 13G

CUSIP No. 266605104                                         Page 6 of 10 Pages

Item 3.           If this statement is filed pursuant to Rule 13d-1(b), or 
                  13d-2(b) or (c), check whether the person filing is a:

                  This Item 3 is not applicable.

Item 4.           Ownership:

Item 4(a)         Amount Beneficially Owned:

                  Each of Sagamore Hill Capital Management, Sagamore Hill 
Managers and Mr. Steven Bloom may be deemed the beneficial owner of 
approximately 3,045,714 shares (assuming the conversion of certain convertible 
bonds held for the account of the Hub Fund).

Item 4(b)         Percent of Class:

                  According to the Issuer's most recent Quarterly Report on Form
10-Q for the quarter ended June 30, 2005, as amended, the Issuer had 52,308,220
Shares outstanding as of July 31, 2005. The number of Shares of which each of 
Sagamore Hill Capital Management, Sagamore Hill Managers and Mr. Steven Bloom 
may be deemed to be the beneficial owner constitutes approximately 5.5% of the 
total number of Shares outstanding (assuming the conversion of certain 
convertible bonds held for the account of the Hub Fund).

Item 4(c)         Number of shares as to which such person has:

    Sagamore Hill Capital Management
    (i)    Sole power to vote or direct the vote:                     3,045,714
    (ii)   Shared power to vote or to direct the vote                         0
    (iii)  Sole power to dispose or to direct the disposition of      3,045,714
    (iv)   Shared power to dispose or to direct the disposition of            0

    Sagamore Hill Managers
    (i)    Sole power to vote or direct the vote:                     3,045,714
    (ii)   Shared power to vote or to direct the vote                         0
    (iii)  Sole power to dispose or to direct the disposition of      3,045,714
    (iv)   Shared power to dispose or to direct the disposition of            0


                                  SCHEDULE 13G

CUSIP No. 266605104                                         Page 7 of 10 Pages

    Mr. Steven Bloom
    (i)    Sole power to vote or direct the vote:                     3,045,714
    (ii)   Shared power to vote or to direct the vote                         0
    (iii)  Sole power to dispose or to direct the disposition of      3,045,714
    (iv)   Shared power to dispose or to direct the disposition of            0

Item 5.           Ownership of Five Percent or Less of a Class:

                  If this Statement is being filed to report the fact that as of
the date hereof the Reporting Persons have ceased to be the beneficial owners of
more than five percent of the class of securities, check the following [  ].

Item 6.           Ownership of More than Five Percent on Behalf of Another 
                  Person:

                  The shareholders of the Hub Fund have the right to participate
in the receipt of dividends from, or proceeds from the sale of, the Shares held
by the Hub Fund in accordance with their ownership interests in the Hub Fund.

Item 7.           Identification and Classification of the Subsidiary Which 
                  Acquired the Security Being Reported on by the Parent Holding 
                  Company or Control Person:

                  This Item 7 is not applicable.

Item 8.           Identification and Classification of Members of the Group:

                  This Item 8 is not applicable.

Item 9.           Notice of Dissolution of Group:

                  This Item 9 is not applicable.

Item 10. Certification:

                  By signing below each of the Reporting Persons certifies that,
to the best of such person's knowledge and belief, the securities referred to 
above were not acquired and are not held for the purpose of or with the effect 
of changing or influencing the control of the Issuer of such securities and were
not acquired and are not held in connection with or as a participant in any
transaction having such purpose or effect.


                                  SCHEDULE 13G

CUSIP No. 266605104                                         Page 8 of 10 Pages

                                   SIGNATURES

         After reasonable inquiry and to the best of my knowledge and belief, 
the undersigned certifies that the information set forth in this statement is 
true, complete and correct.


Date:  August 31, 2005                    SAGAMORE HILL CAPITAL MANAGEMENT L.P.

                                          By: Sagamore Hill Managers LLC,
                                              Its General Partner


                                          By: /s/ Steven H. Bloom
                                              ---------------------------------
                                              Name:  Steven H. Bloom
                                              Title: Manager


Date:  August 31, 2005                    SAGAMORE HILL MANAGERS LLC


                                          By: /s/ Steven H. Bloom
                                              ---------------------------------
                                              Name:  Steven H. Bloom
                                              Title: Manager


Date:  August 31, 2005                    STEVEN H. BLOOM


                                          /s/ Steven H. Bloom
                                          -------------------------------------


                                  SCHEDULE 13G

CUSIP No. 266605104                                         Page 9 of 10 Pages


                                  EXHIBIT INDEX

                                                                       Page No.
                                                                       --------
 
A.     Joint Filing Agreement, dated as of August 31, 2005, by and 
       among Sagamore Hill Capital Management L.P., Sagamore Hill 
       Managers LLC and Mr. Steven H. Bloom........................       10
                                                                            


                                  SCHEDULE 13G

CUSIP No. 266605104                                         Page 10 of 10 Pages

                                    EXHIBIT A

                             JOINT FILING AGREEMENT

                  The undersigned hereby agree that this Initial Statement on 
Schedule 13G with respect to the common stock of Durect Corporation, dated as of
August 31, 2005, is, and any amendments thereto (including amendments on 
Schedule 13D) signed by each of the undersigned shall be, filed on behalf of 
each of us pursuant to and in accordance with the provisions of Rule 13d-1(k) 
under the Securities Exchange Act of 1934.


Date:  August 31, 2005                    SAGAMORE HILL CAPITAL MANAGEMENT L.P.

                                          By: Sagamore Hill Managers LLC,
                                              Its general partner


                                          By: /s/ Steven H. Bloom
                                              ---------------------------------
                                              Name:  Steven H. Bloom     
                                              Title: Manager


Date:  August 31, 2005                      SAGAMORE HILL MANAGERS LLC


                                          By: /s/ Steven H. Bloom
                                              ---------------------------------
                                              Name:  Steven H. Bloom
                                              Title: Manager


Date:  August 31, 2005                    STEVEN H. BLOOM


                                          /s/ Steven H. Bloom
                                          -------------------------------------