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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                  ------------

                                  SCHEDULE 13G
                               (Amendment No. 7)*

                        UNDER THE SECURITIES ACT OF 1934

                           RIGEL PHARMACEUTICALS, INC.
--------------------------------------------------------------------------------
                                (Name of Issuer)

                                  Common Stock
--------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                   766559108
--------------------------------------------------------------------------------
                                 (CUSIP Number)

                                  May 3, 2004
--------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)

Check the  appropriate box to designate the rule pursuant to which this Schedule
is filed:

      |_|   Rule 13d-1(b)

      |X|   Rule 13d-1(c)

      |_|   Rule 13d-1(d)

* The remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any  subsequent  amendment  containing  information  which  would  alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).


                               Page 1 of 18 pages


CUSIP No.  766559108                                          Page 2 of 18 Pages
--------------------------------------------------------------------------------
1     NAMES OF REPORTING PERSONS
      I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

      Alta Partners
--------------------------------------------------------------------------------
2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a)  |_|
                                                                        (b)  |X|
--------------------------------------------------------------------------------
3     SEC USE ONLY


--------------------------------------------------------------------------------
4     CITIZENSHIP OR PLACE OF ORGANIZATION

      California
--------------------------------------------------------------------------------
                  5     SOLE VOTING POWER

                        -0-
                        --------------------------------------------------------
  NUMBER OF       6     SHARED VOTING POWER
   SHARES
BENEFICIALLY            1,880,250
  OWNED BY              Please see Attachment A & Footnote 1
    EACH                --------------------------------------------------------
  REPORTING       7     SOLE DISPOSITIVE POWER
   PERSON
    WITH                -0-
                        --------------------------------------------------------
                  8     SHARED DISPOSITIVE POWER

                        1,880,250
                        Please see Attachment A & Footnote 1
--------------------------------------------------------------------------------
9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      1,880,250         Please see Attachment A and Footnote 1
--------------------------------------------------------------------------------
10    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

      |_|
--------------------------------------------------------------------------------
11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

      11.18%
--------------------------------------------------------------------------------
12    TYPE OF REPORTING PERSON*

      IA
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!

Footnote 1: Includes  the  1,619,833  shares of Common  Stock  and  Warrants  to
            purchase 260,417 shares of Common Stock held by the funds affiliated
            with Alta Partners and Alta Partners II. See Attachment A.


CUSIP No.  766559108                                          Page 3 of 18 Pages
--------------------------------------------------------------------------------
1     NAMES OF REPORTING PERSONS
      I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

      Alta Partners II, Inc.
--------------------------------------------------------------------------------
2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a)  |_|
                                                                        (b)  |X|
--------------------------------------------------------------------------------
3     SEC USE ONLY


--------------------------------------------------------------------------------
4     CITIZENSHIP OR PLACE OF ORGANIZATION

      California
--------------------------------------------------------------------------------
                  5     SOLE VOTING POWER

                        -0-
                        --------------------------------------------------------
  NUMBER OF       6     SHARED VOTING POWER
   SHARES
BENEFICIALLY            1,880,250
  OWNED BY              Please see Attachment A & Footnote 2
    EACH                --------------------------------------------------------
  REPORTING       7     SOLE DISPOSITIVE POWER
   PERSON
    WITH                -0-
                        --------------------------------------------------------
                  8     SHARED DISPOSITIVE POWER

                        1,880,250
                        Please see Attachment A & Footnote 2
--------------------------------------------------------------------------------
9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      1,880,250         Please see Attachment A and Footnote 2
--------------------------------------------------------------------------------
10    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

      |_|
--------------------------------------------------------------------------------
11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

      11.18%
--------------------------------------------------------------------------------
12    TYPE OF REPORTING PERSON*

      IA
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!

Footnote 2: Includes  the  1,619,833  shares of Common  Stock  and  Warrants  to
            purchase 260,417 shares of Common Stock held by the funds affiliated
            with Alta Partners and Alta Partners II. See Attachment A.


CUSIP No.  766559108                                          Page 4 of 18 Pages
--------------------------------------------------------------------------------
1     NAMES OF REPORTING PERSONS
      I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

      Alta California Partners, L. P.
--------------------------------------------------------------------------------
2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a)  |_|
                                                                        (b)  |X|
--------------------------------------------------------------------------------
3     SEC USE ONLY


--------------------------------------------------------------------------------
4     CITIZENSHIP OR PLACE OF ORGANIZATION

      Delaware
--------------------------------------------------------------------------------
                  5     SOLE VOTING POWER

                        -0-
                        --------------------------------------------------------
  NUMBER OF       6     SHARED VOTING POWER
   SHARES
BENEFICIALLY            1,880,250
  OWNED BY              Please see Attachment A & Footnote 3
    EACH                --------------------------------------------------------
  REPORTING       7     SOLE DISPOSITIVE POWER
   PERSON
    WITH                -0-
                        --------------------------------------------------------
                  8     SHARED DISPOSITIVE POWER

                        1,880,250
                        Please see Attachment A & Footnote 3
--------------------------------------------------------------------------------
9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      1,880,250         Please see Attachment A and Footnote 3
--------------------------------------------------------------------------------
10    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

      |_|
--------------------------------------------------------------------------------
11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

      11.18%
--------------------------------------------------------------------------------
12    TYPE OF REPORTING PERSON*

      PN
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!

Footnote 3: Includes  the  1,619,833  shares of Common  Stock  and  Warrants  to
            purchase 260,417 shares of Common Stock held by the funds affiliated
            with Alta Partners and Alta Partners II. See Attachment A.


CUSIP No.  766559108                                          Page 5 of 18 Pages
--------------------------------------------------------------------------------
1     NAMES OF REPORTING PERSONS
      I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

      Alta California Management Partners, L. P.
--------------------------------------------------------------------------------
2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a)  |_|
                                                                        (b)  |X|
--------------------------------------------------------------------------------
3     SEC USE ONLY


--------------------------------------------------------------------------------
4     CITIZENSHIP OR PLACE OF ORGANIZATION

      Delaware
--------------------------------------------------------------------------------
                  5     SOLE VOTING POWER

                        -0-
                        --------------------------------------------------------
  NUMBER OF       6     SHARED VOTING POWER
   SHARES
BENEFICIALLY            1,880,250
  OWNED BY              Please see Attachment A & Footnote 4
    EACH                --------------------------------------------------------
  REPORTING       7     SOLE DISPOSITIVE POWER
   PERSON
    WITH                -0-
                        --------------------------------------------------------
                  8     SHARED DISPOSITIVE POWER

                        1,880,250
                        Please see Attachment A & Footnote 4
--------------------------------------------------------------------------------
9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      1,880,250         Please see Attachment A and Footnote 4
--------------------------------------------------------------------------------
10    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

      |_|
--------------------------------------------------------------------------------
11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

      11.18%
--------------------------------------------------------------------------------
12    TYPE OF REPORTING PERSON*

      PN
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!

Footnote 4: Includes  the  1,619,833  shares of Common  Stock  and  Warrants  to
            purchase 260,417 shares of Common Stock held by the funds affiliated
            with Alta Partners and Alta Partners II. See Attachment A.


CUSIP No.  766559108                                          Page 6 of 18 Pages
--------------------------------------------------------------------------------
1     NAMES OF REPORTING PERSONS
      I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

      Alta Embarcadero Partners, LLC
--------------------------------------------------------------------------------
2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a)  |_|
                                                                        (b)  |X|
--------------------------------------------------------------------------------
3     SEC USE ONLY


--------------------------------------------------------------------------------
4     CITIZENSHIP OR PLACE OF ORGANIZATION

      California
--------------------------------------------------------------------------------
                  5     SOLE VOTING POWER

                        -0-
                        --------------------------------------------------------
  NUMBER OF       6     SHARED VOTING POWER
   SHARES
BENEFICIALLY            1,880,250
  OWNED BY              Please see Attachment A & Footnote 5
    EACH                --------------------------------------------------------
  REPORTING       7     SOLE DISPOSITIVE POWER
   PERSON
    WITH                -0-
                        --------------------------------------------------------
                  8     SHARED DISPOSITIVE POWER

                        1,880,250
                        Please see Attachment A & Footnote 5
--------------------------------------------------------------------------------
9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      1,880,250         Please see Attachment A and Footnote 5
--------------------------------------------------------------------------------
10    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

      |_|
--------------------------------------------------------------------------------
11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

      11.18%
--------------------------------------------------------------------------------
12    TYPE OF REPORTING PERSON*

      CO
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!

Footnote 5: Includes  the  1,619,833  shares of Common  Stock  and  Warrants  to
            purchase 260,417 shares of Common Stock held by the funds affiliated
            with Alta Partners and Alta Partners II. See Attachment A.


CUSIP No.  766559108                                          Page 7 of 18 Pages
--------------------------------------------------------------------------------
1     NAMES OF REPORTING PERSONS
      I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

      Alta BioPharma Partners II, L.P.
--------------------------------------------------------------------------------
2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a)  |_|
                                                                        (b)  |X|
--------------------------------------------------------------------------------
3     SEC USE ONLY


--------------------------------------------------------------------------------
4     CITIZENSHIP OR PLACE OF ORGANIZATION

      Delaware
--------------------------------------------------------------------------------
                  5     SOLE VOTING POWER

                        -0-
                        --------------------------------------------------------
  NUMBER OF       6     SHARED VOTING POWER
   SHARES
BENEFICIALLY            1,880,250
  OWNED BY              Please see Attachment A & Footnote 6
    EACH                --------------------------------------------------------
  REPORTING       7     SOLE DISPOSITIVE POWER
   PERSON
    WITH                -0-
                        --------------------------------------------------------
                  8     SHARED DISPOSITIVE POWER

                        1,880,250
                        Please see Attachment A & Footnote 6
--------------------------------------------------------------------------------
9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      1,880,250         Please see Attachment A and Footnote 6
--------------------------------------------------------------------------------
10    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

      |_|
--------------------------------------------------------------------------------
11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

      11.18%
--------------------------------------------------------------------------------
12    TYPE OF REPORTING PERSON*

      PN
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!

Footnote 6: Includes  the  1,619,833  shares of Common  Stock  and  Warrants  to
            purchase 260,417 shares of Common Stock held by the funds affiliated
            with Alta Partners and Alta Partners II. See Attachment A.


CUSIP No.  766559108                                          Page 8 of 18 Pages
--------------------------------------------------------------------------------
1     NAMES OF REPORTING PERSONS
      I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

      Alta BioPharma Management Partners II, LLC.
--------------------------------------------------------------------------------
2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a)  |_|
                                                                        (b)  |X|
--------------------------------------------------------------------------------
3     SEC USE ONLY


--------------------------------------------------------------------------------
4     CITIZENSHIP OR PLACE OF ORGANIZATION

      Delware
--------------------------------------------------------------------------------
                  5     SOLE VOTING POWER

                        -0-
                        --------------------------------------------------------
  NUMBER OF       6     SHARED VOTING POWER
   SHARES
BENEFICIALLY            1,880,250
  OWNED BY              Please see Attachment A & Footnote 7
    EACH                --------------------------------------------------------
  REPORTING       7     SOLE DISPOSITIVE POWER
   PERSON
    WITH                -0-
                        --------------------------------------------------------
                  8     SHARED DISPOSITIVE POWER

                        1,880,250
                        Please see Attachment A & Footnote 7
--------------------------------------------------------------------------------
9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      1,880,250         Please see Attachment A and Footnote 7
--------------------------------------------------------------------------------
10    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

      |_|
--------------------------------------------------------------------------------
11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

      11.18%
--------------------------------------------------------------------------------
12    TYPE OF REPORTING PERSON*

      CO
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!

Footnote 7: Includes  the  1,619,833  shares of Common  Stock  and  Warrants  to
            purchase 260,417 shares of Common Stock held by the funds affiliated
            with Alta Partners and Alta Partners II. See Attachment A.


CUSIP No.  766559108                                          Page 9 of 18 Pages
--------------------------------------------------------------------------------
1     NAMES OF REPORTING PERSONS
      I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

      Alta Embarcadero BioPharma Partners II, LLC.
--------------------------------------------------------------------------------
2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a)  |_|
                                                                        (b)  |X|
--------------------------------------------------------------------------------
3     SEC USE ONLY


--------------------------------------------------------------------------------
4     CITIZENSHIP OR PLACE OF ORGANIZATION

      Delaware
--------------------------------------------------------------------------------
                  5     SOLE VOTING POWER

                        -0-
                        --------------------------------------------------------
  NUMBER OF       6     SHARED VOTING POWER
   SHARES
BENEFICIALLY            1,880,250
  OWNED BY              Please see Attachment A & Footnote 8
    EACH                --------------------------------------------------------
  REPORTING       7     SOLE DISPOSITIVE POWER
   PERSON
    WITH                -0-
                        --------------------------------------------------------
                  8     SHARED DISPOSITIVE POWER

                        1,880,250
                        Please see Attachment A & Footnote 8
--------------------------------------------------------------------------------
9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      1,880,250         Please see Attachment A and Footnote 8
--------------------------------------------------------------------------------
10    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

      |_|
--------------------------------------------------------------------------------
11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

      11.18%
--------------------------------------------------------------------------------
12    TYPE OF REPORTING PERSON*

      CO
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!

Footnote 8: Includes  the  1,619,833  shares of Common  Stock  and  Warrants  to
            purchase 260,417 shares of Common Stock held by the funds affiliated
            with Alta Partners and Alta Partners II. See Attachment A.


CUSIP No.  766559108                                         Page 10 of 18 Pages
--------------------------------------------------------------------------------
1     NAMES OF REPORTING PERSONS
      I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

      Farah Champsi
--------------------------------------------------------------------------------
2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a)  |_|
                                                                        (b)  |X|
--------------------------------------------------------------------------------
3     SEC USE ONLY


--------------------------------------------------------------------------------
4     CITIZENSHIP OR PLACE OF ORGANIZATION

      United States
--------------------------------------------------------------------------------
                  5     SOLE VOTING POWER

                        -0-
                        --------------------------------------------------------
  NUMBER OF       6     SHARED VOTING POWER
   SHARES
BENEFICIALLY            1,481,943
  OWNED BY              Please see Attachment A & Footnote 9
    EACH                --------------------------------------------------------
  REPORTING       7     SOLE DISPOSITIVE POWER
   PERSON
    WITH                -0-
                        --------------------------------------------------------
                  8     SHARED DISPOSITIVE POWER

                        1,481,943
                        Please see Attachment A & Footnote 9
--------------------------------------------------------------------------------
9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      1,481,943         Please see Attachment A and Footnote 9
--------------------------------------------------------------------------------
10    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

      |_|
--------------------------------------------------------------------------------
11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

      8.81%
--------------------------------------------------------------------------------
12    TYPE OF REPORTING PERSON*

      IN
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!

Footnote 9: Includes  the  1,256,249  shares of Common  Stock  and  Warrants  to
            purchase 225,694 shares of Common Stock held by the funds affiliated
            with Alta Partners II. See Attachment A.


CUSIP No.  766559108                                         Page 11 of 18 Pages
--------------------------------------------------------------------------------
1     NAMES OF REPORTING PERSONS
      I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

      Jean Deleage
--------------------------------------------------------------------------------
2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a)  |_|
                                                                        (b)  |X|
--------------------------------------------------------------------------------
3     SEC USE ONLY


--------------------------------------------------------------------------------
4     CITIZENSHIP OR PLACE OF ORGANIZATION

      United States
--------------------------------------------------------------------------------
                  5     SOLE VOTING POWER

                        11,112
                        --------------------------------------------------------
  NUMBER OF       6     SHARED VOTING POWER
   SHARES
BENEFICIALLY            1,880,250
  OWNED BY              Please see Attachment A & Footnote 10
    EACH                --------------------------------------------------------
  REPORTING       7     SOLE DISPOSITIVE POWER
   PERSON
    WITH                11,112
                        --------------------------------------------------------
                  8     SHARED DISPOSITIVE POWER

                        1,880,250
                        Please see Attachment A & Footnote 10
--------------------------------------------------------------------------------
9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      1,891,362         Please see Attachment A and Footnote 10
--------------------------------------------------------------------------------
10    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

      |_|
--------------------------------------------------------------------------------
11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

      11.24%
--------------------------------------------------------------------------------
12    TYPE OF REPORTING PERSON*

      IN
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!

Footnote 10: Includes the 1,619,833 shares of Common Stock, Warrants to purchase
             260,417 shares of Common Stock, and Stock Options for 11,112 shares
             of Common Stock. See Attachment A.


CUSIP No.  766559108                                         Page 12 of 18 Pages
--------------------------------------------------------------------------------
1     NAMES OF REPORTING PERSONS
      I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

      Garrett Gruener
--------------------------------------------------------------------------------
2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a)  |_|
                                                                        (b)  |X|
--------------------------------------------------------------------------------
3     SEC USE ONLY


--------------------------------------------------------------------------------
4     CITIZENSHIP OR PLACE OF ORGANIZATION

      United States
--------------------------------------------------------------------------------
                  5     SOLE VOTING POWER

                        -0-
                        --------------------------------------------------------
  NUMBER OF       6     SHARED VOTING POWER
   SHARES
BENEFICIALLY            398,307
  OWNED BY              Please see Attachment A & Footnote 11
    EACH                --------------------------------------------------------
  REPORTING       7     SOLE DISPOSITIVE POWER
   PERSON
    WITH                -0-
                        --------------------------------------------------------
                  8     SHARED DISPOSITIVE POWER

                        398,307
                        Please see Attachment A & Footnote 11
--------------------------------------------------------------------------------
9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      398,307           Please see Attachment A and Footnote 11
--------------------------------------------------------------------------------
10    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

      |_|
--------------------------------------------------------------------------------
11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

      2.37%
--------------------------------------------------------------------------------
12    TYPE OF REPORTING PERSON*

      IN
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!

Footnote 11: Includes  the  363,584  shares of  Common  Stock  and  Warrants  to
             purchase 34,723 shares of Common Stock held by the funds affiliated
             with Alta Partners. See Attachment A.


CUSIP No.  766559108                                         Page 13 of 18 Pages
--------------------------------------------------------------------------------
1     NAMES OF REPORTING PERSONS
      I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

      Alix Marduel
--------------------------------------------------------------------------------
2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a)  |_|
                                                                        (b)  |X|
--------------------------------------------------------------------------------
3     SEC USE ONLY


--------------------------------------------------------------------------------
4     CITIZENSHIP OR PLACE OF ORGANIZATION

      United States
--------------------------------------------------------------------------------
                  5     SOLE VOTING POWER

                        -0-
                        --------------------------------------------------------
  NUMBER OF       6     SHARED VOTING POWER
   SHARES
BENEFICIALLY            1,481,943
  OWNED BY              Please see Attachment A & Footnote 12
    EACH                --------------------------------------------------------
  REPORTING       7     SOLE DISPOSITIVE POWER
   PERSON
    WITH                -0-
                        --------------------------------------------------------
                  8     SHARED DISPOSITIVE POWER

                        1,481,943
                        Please see Attachment A & Footnote 12
--------------------------------------------------------------------------------
9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      1,481,943         Please see Attachment A and Footnote 12
--------------------------------------------------------------------------------
10    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

      |_|
--------------------------------------------------------------------------------
11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

      8.81%
--------------------------------------------------------------------------------
12    TYPE OF REPORTING PERSON*

      IN
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!

Footnote 12: Includes  the  1,256,249  shares of Common  Stock and  Warrants  to
             purchase   225,694  shares  of  Common  Stock  held  by  the  funds
             affiliated with Alta Partners II. See Attachment A.


CUSIP No.  766559108                                         Page 14 of 18 Pages
--------------------------------------------------------------------------------
1     NAMES OF REPORTING PERSONS
      I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

      Guy Nohra
--------------------------------------------------------------------------------
2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                        (a)  |_|
                                                                        (b)  |X|
--------------------------------------------------------------------------------
3     SEC USE ONLY


--------------------------------------------------------------------------------
4     CITIZENSHIP OR PLACE OF ORGANIZATION

      United States
--------------------------------------------------------------------------------
                  5     SOLE VOTING POWER

                        -0-
                        --------------------------------------------------------
  NUMBER OF       6     SHARED VOTING POWER
   SHARES
BENEFICIALLY            398,307
  OWNED BY              Please see Attachment A & Footnote 13
    EACH                --------------------------------------------------------
  REPORTING       7     SOLE DISPOSITIVE POWER
   PERSON
    WITH                -0-
                        --------------------------------------------------------
                  8     SHARED DISPOSITIVE POWER

                        398,307
                        Please see Attachment A & Footnote 13
--------------------------------------------------------------------------------
9     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

      398,307           Please see Attachment A and Footnote 13
--------------------------------------------------------------------------------
10    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

      |_|
--------------------------------------------------------------------------------
11    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

      2.37%
--------------------------------------------------------------------------------
12    TYPE OF REPORTING PERSON*

      IN
--------------------------------------------------------------------------------
                      *SEE INSTRUCTION BEFORE FILLING OUT!

Footnote 13: Includes  the  363,584  shares of  Common  Stock  and  Warrants  to
             purchase 34,723 shares of Common Stock held by the funds affiliated
             with Alta Partners. See Attachment A.


CUSIP No.  766559108                                         Page 15 of 18 Pages
--------------------------------------------------------------------------------
Item 1.

(a) Name of Issuer: Rigel Pharmaceuticals, Inc. ("Issuer")

(b) Address of Issuer's Principal Executive Offices:

                  1180 Veterans Boulevard
                  South San Francisco, CA 94080

Item 2.

(a) Name of Person Filing:

         Alta Partners ("AP")
         Alta Partners II, Inc. ("AP II")
         Alta California Partners, L.P. ("ACP")
         Alta California Management Partners, L.P. ("ACMP")
         Alta Embarcadero Partners, LLC ("AEP")
         Alta BioPharma Partners II, L.P. ("ABP II")
         Alta BioPharma Management Partners II, LLC ("ABMP II")
         Alta Embarcadero BioPharma Partners II, LLC ("AEBP II")
         Farah Champsi ("FC")
         Jean Deleage ("JD")
         Garrett Gruener ("GG")
         Alix Marduel ("AM")
         Guy Nohra ("GN")

 (b) Address of Principal Business Office:

         One Embarcadero Center, Suite 4050
         San Francisco, CA  94111

 (c) Citizenship/Place of Organization:


         Entities:         AP               California
                           AP II            California
                           ACP              Delaware
                           ACMP             Delaware
                           AEP              California
                           ABP II           Delaware
                           ABMP II          Delaware
                           AEBP II          California

         Individuals:      FC               United States
                           JD               United States
                           GG               United States
                           AM               United States
                           GN               United States


(d) Title of Class of Securities: Common Stock

(e) CUSIP Number: 766559108

CUSIP No.  766559108                                         Page 16 of 18 Pages
--------------------------------------------------------------------------------

Item 3.  Not applicable.

Item 4         Ownership.
                             Please see Attachment A


               The numbers listed below reflect the 1:9 Reverse Stock Split
effective June 26, 2003.
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
                               AP        AP II         ACP         ACMP         AEP         ABP II       ABMP II
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
                                                                                   
(a)     Beneficial         1,880,250   1,880,250    1,880,250   1,880,250    1,880,250     1,880,250    1,880,250
        Ownership
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
(b)     Percentage of        11.18%      11.18%      11.18%       11.18%       11.18%       11.18%        11.18%
        Class
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
(c)     Sole Voting Power     -0-         -0-          -0-         -0-          -0-           -0-          -0-
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
        Shared Voting      1,880,250   1,880,250    1,880,250   1,880,250    1,880,250     1,880,250    1,880,250
        Power
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
        Sole Dispositive      -0-         -0-          -0-         -0-          -0-           -0-          -0-
        Power
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
        Shared             1,880,250   1,880,250    1,880,250   1,880,250    1,880,250     1,880,250    1,880,250
        Dispositive Power
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
                            AEBP II        FC          JD           GG           AM           GN
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
(a)     Beneficial         1,880,250   1,481,943    1,891,362    398,307     1,481,943      398,307
        Ownership
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
(b)     Percentage of        11.18%      8.81%       11.24%       2.37%        8.81%         2.37%
        Class
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
(c)     Sole Voting Power     -0-         -0-        11,112        -0-          -0-           -0-
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
        Shared Voting      1,880,250    1,481,943   1,880,250    398,307     1,481,943      398,307
        Power
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
        Sole Dispositive      -0-          -0-       11,112        -0-          -0-           -0-
        Power
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------
        Shared             1,880,250    1,481,943   1,880,250    398,307     1,481,943      398,307
        Dispositive Power
------- ------------------ ----------- ----------- ------------ ----------- ------------- ------------ -------------


Item 5.        Ownership of Five Percent or Less of a Class

Not Applicable.

Item 6.        Ownership of More than Five Percent on Behalf of Another Person

Not applicable.

Item 7.        Identification   and   Classification  of  the  Subsidiary  Which
               Acquired the  Security  Being  Reported on By the Parent  Holding
               Company.

Not applicable.

CUSIP No.  766559108                                         Page 17 of 18 Pages
--------------------------------------------------------------------------------

Item 8.        Identification and Classification of Members of the Group

No reporting person is a member of a group as defined in Section
240.13d-1(b)(1)(ii)(H) of the Act.

Item 9.        Notice of Dissolution of Group

Not applicable.

Item 10.       Certification

By signing below we certify  that, to the best of our knowledge and belief,  the
securities  referred to above were acquired and are held in the ordinary  course
of business  and were not  acquired  and are not held for the purpose of or with
the  effect  of  changing  or  influencing  the  control  of the  issuer  of the
securities  and were not  acquired and are not held in  connection  with or as a
participant in any transaction having that purpose or effect.

EXHIBITS

A:       Joint Filing Statement


CUSIP No.  766559108                                         Page 18 of 18 Pages
--------------------------------------------------------------------------------


                                    Signature

         After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

Date:    April 5, 2004



                                                  
ALTA PARTNERS                                        ALTA CALIFORNIA PARTNERS, L.P.

                                                     By:  Alta California Management Partners, L.P.,


By:      /s/ Jean Deleage                            By:               /s/ Jean Deleage          .
   -----------------------------------------            ------------------------------------------
         Jean Deleage, President                              Jean Deleage, General Partner


ALTA CALIFORNIA MANAGEMENT PARTNERS, L.P.            ALTA EMBARCADERO PARTNERS, LLC



By:      /s/ Jean Deleage                            By:      /s/ Jean Deleage
   -----------------------------------------            -----------------------------------------
         Jean Deleage, General Partner                                 Jean Deleage, Member

ALTA  PARTNERS II, INC.

By:      /s/ Jean Deleage
   -----------------------------------------
         Jean Deleage, President

ALTA BIOPHARMA PARTNERS II, L.P.                           ALTA BIOPHARMA MANAGEMENT PARTNERS II, LLC
By: Alta BioPharma Management Partners II, LLC


By:      /s/ Farah Champsi                           By:      /s/ Farah Champsi
   -----------------------------------------            -----------------------------------------
         Farah Champsi, Managing Director                     Farah Champsi, Managing Director

ALTA EMBARCADERO BIOPHARMA PARTNERS II, LLC


By:      /s/ Farah Champsi                                    /s/ Alix Marduel
   -----------------------------------------         --------------------------------------------
         Farah Champsi, Manager                               Alix Marduel


         /s/ Jean Deleage                                     /s/ Guy Nohra
   -----------------------------------------         --------------------------------------------
         Jean Deleage                                        Guy Nohra


         /s/ Garrett Gruener                                 /s/ Farah Champsi
   -----------------------------------------         --------------------------------------------
         Garrett Gruener                                     Farah Champsi



                                    EXHIBIT A

                            AGREEMENT OF JOINT FILING

Date:    April 5, 2004

                                    Signature

         After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct. ALTA PARTNERS ALTA CALIFORNIA PARTNERS, L.P.


                                                  
                                                     By:  Alta California Management Partners, L.P.,


By:      /s/ Jean Deleage                            By:               /s/ Jean Deleage          .
   -----------------------------------------            ------------------------------------------
         Jean Deleage, President                              Jean Deleage, General Partner


ALTA CALIFORNIA MANAGEMENT PARTNERS, L.P.            ALTA EMBARCADERO PARTNERS, LLC



By:      /s/ Jean Deleage                            By:      /s/ Jean Deleage
   -----------------------------------------            -----------------------------------------
         Jean Deleage, General Partner                                 Jean Deleage, Member

ALTA  PARTNERS II, INC.

By:      /s/ Jean Deleage
         Jean Deleage, President

ALTA BIOPHARMA PARTNERS II, L.P.                           ALTA BIOPHARMA MANAGEMENT PARTNERS II, LLC
By: Alta BioPharma Management Partners II, LLC


By:      /s/ Farah Champsi                           By:      /s/ Farah Champsi
   -----------------------------------------            -----------------------------------------
         Farah Champsi, Managing Director                     Farah Champsi, Managing Director

ALTA EMBARCADERO BIOPHARMA PARTNERS II, LLC


By:      /s/ Farah Champsi                                    /s/ Alix Marduel
   -----------------------------------------         --------------------------------------------
         Farah Champsi, Manager                               Alix Marduel


         /s/ Jean Deleage                                     /s/ Guy Nohra
   -----------------------------------------         --------------------------------------------
         Jean Deleage                                        Guy Nohra


         /s/ Garrett Gruener                                 /s/ Farah Champsi
   -----------------------------------------         --------------------------------------------
         Garrett Gruener                                     Farah Champsi


                                  Attachment A

Alta Partners provides  investment  advisory services to several venture capital
funds including Alta California  Partners,  L.P. and Alta Embarcadero  Partners,
LLC. Alta California Partners,  L.P.  beneficially owns 355,465 shares of Common
Stock and Warrants to purchase 33,947 shares of Common Stock.  Alta  Embarcadero
Partners,  LLC  beneficially  owns 8,119  shares of Common Stock and Warrants to
purchase 776 shares of Common Stock. The respective general partners and members
of Alta California  Partners L.P. and Alta  Embarcadero  Partners,  LLC exercise
sole voting and investment power with respect to the shares owned by such funds.

Certain  principals  of Alta  Partners are general  partners of Alta  California
Management  Partners,  L.P.  (which  is a  general  partner  of Alta  California
Partners, L.P.), and members Alta Embarcadero Partners, LLC. As general partners
and members of such  funds,  they may be deemed to share  voting and  investment
powers  over the  shares  held by the funds.  The  principals  of Alta  Partners
disclaim  beneficial  ownership of all such shares held by the foregoing  funds,
except to the extent of their proportionate pecuniary interests therein.

Alta Partners II, Inc. provides  investment advisory services to several venture
capital funds  including Alta BioPharma  Partners II, L.P. and Alta  Embarcadero
BioPharma Partners II, LLC. Alta BioPharma  Partners II, L.P.  beneficially owns
1,211,676  shares of Common  Stock and  Warrants to purchase  217,686  shares of
Common stock.  Alta Embarcadero  BioPharma  Partners II, LLC  beneficially  owns
44,573  shares  Common  Stock and  Warrants to purchase  8,008  shares of Common
Stock. The managing  directors of Alta BioPharma  Partners II, L.P. and managers
of Alta  Embarcadero  BioPharma  Partners  II,  LLC  exercise  sole  voting  and
investment power in respect to the shares owned by such funds.

Certain  principals  of Alta  Partners II, Inc.  are managing  directors of Alta
BioPharma  Management  II, LLC (which is the general  partner of Alta  BioPharma
Partners II, L.P.), and managers of Alta Embarcadero BioPharma Partners II, LLC.
As managing directors and managers of such entities, they may be deemed to share
voting and investment powers over the shares beneficially held by the funds. The
principals of Alta Partners II, Inc. disclaim  beneficial  ownership of all such
shares held by the foregoing funds,  except to the extent of their proportionate
pecuniary interests therein.

Mr. Jean Deleage,  Director, is a managing director of Alta BioPharma Management
Partners II, LLC (which is the general  partner of Alta  BioPharma  Partners II,
L.P.),  a manager of Alta  Embarcadero  BioPharma  Partners  II,  LLC, a general
partner of Alta  California  Management  Partners,  L.P.  (which is the  general
partner of Alta California  Partners,  L.P.),  and a member of Alta  Embarcadero
Partners,  LLC. Thus he currently shares voting and dispositive  powers over the
1,429,362 shares of Common Stock  beneficially  owned by Alta BioPharma Partners
II,  L.P.,  the  52,581  shares  of  Common  Stock  beneficially  owned  by Alta
Embarcadero  BioPharma  Partners  II, LLC,  the 389,412  shares of Common  Stock
beneficially  owned by Alta  California  Partners  L.P.  and the 8,895 shares of
Common Stock beneficially owned by Alta Embarcadero Partners,  LLC. He disclaims
beneficial  ownership  of all such  shares  held by all of the  foregoing  funds
except to the extent of his proportionate  pecuniary interests therein. He holds
stock options for 11,112  shares of Common Stock:  options for 8,333 shares were
granted on January 26, 2004  options for 1,667  shares were  granted on June 26,
2003,  options for 556 shares were  granted on June 20, 2002 and options for 556
shares were granted on July 19, 2001.

Ms. Farah Champsi is a managing director of Alta BioPharma  Management  Partners
II, LLC (which is the general partner of Alta BioPharma Partners II, L.P.) and a
manager of Alta  Embarcadero  BioPharma  Partners  II, LLC.  Thus she  currently
shares voting and dispositive  powers over the 1,429,362  shares of Common Stock
beneficially  owned by Alta BioPharma Partners II, L.P. and the 52,581 shares of
Common Stock beneficially owned by Alta Embarcadero  BioPharma Partners II, LLC.
She  disclaims  beneficial  ownership  of all  such  shares  held  by all of the
foregoing funds except to the extent of her  proportionate  pecuniary  interests
therein.

Mr. Garrett Gruener is a general partner of Alta California Management Partners,
L.P.  (which is the general  partner of Alta  California  Partners,  L.P.) and a
member of Alta Embarcadero Partners,  LLC. Thus he shares voting and dispositive
powers  over the  389,412  shares of  Common  Stock  beneficially  owned by Alta
California  Partners L.P. and 8,895 shares of Common stock beneficially owned by
Alta  Embarcadero  Partners LLC. He disclaims  beneficial  ownership of all such
shares  held  by  all  of the  foregoing  funds  except  to  the  extent  of his
proportionate pecuniary interests therein.

                                                     Page 1 of 2 of Attachment A

                            Attachment A (continued)


Dr. Alix Marduel is a managing  director of Alta BioPharma  Management  Partners
II, LLC (which is the general partner of Alta BioPharma Partners II, L.P.) and a
manager of Alta  Embarcadero  BioPharma  Partners  II, LLC.  Thus she  currently
shares voting and dispositive  powers over the 1,429,362  shares of Common Stock
beneficially  owned by Alta BioPharma Partners II, L.P. and the 52,581 shares of
Common Stock beneficially owned by Alta Embarcadero  BioPharma Partners II, LLC.
She  disclaims  beneficial  ownership  of all  such  shares  held  by all of the
foregoing funds except to the extent of her  proportionate  pecuniary  interests
therein.

Mr. Guy Nohra is a general partner of Alta California Management Partners,  L.P.
(which is the general partner of Alta California Partners, L.P.). Thus he shares
voting  and  dispositive   powers  over  the  389,412  shares  of  Common  Stock
beneficially  owned by Alta  California  Partners  L.P. He disclaims  beneficial
ownership  of all such shares held by all of the  foregoing  funds except to the
extent of his proportionate pecuniary interests therein.

Alta Partners and Alta Partners II, Inc. are venture capital firms that share an
office in San Francisco. Alta Partners is California Corporation.  Alta Partners
II,  Inc. is a  California  Corporation.  Alta  California  Partners,  L.P. is a
Delaware Limited  Partnership,  Alta Embarcadero  Partners,  LLC is a California
Limited  Liability  Company,  Alta  BioPharma  Partners  II,  L.P. is a Delaware
Limited  Partnership,  and Alta  Embarcadero  BioPharma  Partners  II,  LLC is a
California Limited Liability Company.



















                                                     Page 2 of 2 of Attachment A