UNITED STATES
                            WASHINGTON, D.C. 20549

                                  SCHEDULE 14A
                                 (RULE 14a-101)


                            SCHEDULE 14A INFORMATION

                    EXCHANGE ACT OF 1934 (AMENDMENT NO.   )

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[ ]  Preliminary Proxy Statement          [ ]  Confidential, for Use of the
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                         Cytoclonal Pharmaceutics Inc.
                (Name of Registrant as Specified In Its Charter)

   (Name of Person(s) Filing Proxy Statement, if other than the Registrant)

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                          CYTOCLONAL PHARMACEUTICS INC.

                                  SUPPLEMENT TO
                                 PROXY STATEMENT
                         ANNUAL MEETING OF STOCKHOLDERS
                         ORIGINALLY SCHEDULED TO BE HELD
                          ON JUNE 4, 2001 AND ADJOURNED
                               UNTIL JUNE 15, 2001

To the Stockholders of
Cytoclonal Pharmaceutics Inc.

         Please be advised that the Annual Meeting of Stockholders scheduled to
be held on June 4, 2001, was adjourned with respect to consideration of Proposal
3, relating to amendments to the Company's 2000 Stock Option Plan that include
an increase in the number of incentive stock options and nonqualified stock
options available for grant, and a change in the vesting period for options. The
adjourned annual meeting will be held at 2110 Research Row, Suite 601, Dallas,
Texas 75235, on Friday, June 15, 2001, at 9:00 a.m., local time to consider and
act upon Proposal 3. We hope you have had an opportunity to read the Proxy
Statement dated May 1, 2001 (the "Proxy Statement"), and to consider the matters
that were to be presented at the Company's annual meeting.

         If you do not plan to attend the annual meeting on June 15, 2001, and
you have not already voted or you wish to change your vote with respect to
Proposal 3, we urge you to vote the enclosed proxy card by mail or by facsimile
to (718) 234-2287. Proposals 1 and 2 have been closed and have been approved by
the requisite vote of the Company's stockholders.


         In addition, this letter supplements and amends the language appearing
in the sixth sentence of the first paragraph under "Voting Securities" on page 2
of the Proxy Statement to clarify that a majority vote of the shares present in
person or represented by proxy at the Annual Meeting and entitled to vote on the
proposal is required for approval of Proposal 3.

         We look forward to receiving your signed and dated proxy at your
earliest convenience, and we thank you for your prompt attention to this
request. This Supplement is being mailed to the Company's stockholders on or
about June 4, 2001.

                                      By Order of the Board of Directors,

                                      Daniel M. Shusterman, Secretary
Date: June 4, 2001